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Z[ 8e~  /  GACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GCACNNNNNNGTTSAACNNNNNNGTGC,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNNNNTTYG,CRAANNNNNNGTC,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,TCGGTC,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,TTSAA,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GCTCC,GGAGC,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,CCDG,CHGG,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                                  +                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             	                                                                                                                                                                                                             &                	                                                                     "                                                                                               
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   
                                 !   4             (      $             s   N          h   X               [                                                                                                                                                                       +                                                                                                                                                                                                                                                                                                               	                                                                           &      	                         "                                 
          2  	   	                       
 
           ! 4     (  $     s N    h X     [   nw  o  o  o  t  x  s_,"Uz$SWJj 
Po4J Wbs/)=MQ>S>St)ey Mk&Oy=W`		'
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Fe;y-6y'}Ns4~N	4N4NNNNNb17o*eY  e\R A~3UvJcF4|4,r=Q]?F0j<K	
x^l
%w["BUg8~ r=QQ  ep -cR R ? ;R"g8-c	

R}i		
M{f'
*_
g
> C<K	


xGc_3',4&A"|K
<a%OAC	5cC*\0\o"%S
BU	 
mBUe=xa%  -c;	

R|?a%5BNw MK*.G`p			\
j

}F6u a%C
	K C=H Vv		Cxf	-c3'T%0 ]|F  ]nm
R|?F   ((!YL0c+B|  A|z2a 
*	C
b'	
]F4&,A[fS >d) "Cv?
! == MI{AXbR~Y5O*BeD	P]yy"| &)o/H
]oSV$l L\)`cK}7Ne
J)H
SV$ &o/]ol	]u
(
O;  &),ODo/]$
2
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	BEW]orSV$l9R~Y5O*BeD	K}P]7N/u	F-08 hSt	X{{O\I  g8s	0.%& hl 		*1 'Cr		W	#2C& l  		h*:O7jhzV		TN["dw;RNh+k
L~5
% NsX/4\_^<?P@E!;B5 vAWJ		
c|r)p,za)_x&/	9	
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HWdZ37A
M
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1
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NCD"$/yf< 3O[iP,j3E^Q
l
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'E%/ry~9*  #Dwyk
? .d1J.	
T5vPVlcYu  G
'
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h
 D#?`n0g 		
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"NR   DYy1NUMf>>IQi{ L\#)-CVh9acWT
v1K}8]O &b&p	8cx}G    "LU.d\h#)1~-CJ.V\ho					



9A9ITa5GvlPVlnc	XWcOY ?   &(*;&.b#%&7p		*RT`8@ciFw)Lx6mJ}sLqf>\

R`={   (n {t	ESd9nI V  R ~Yj5W).JO*$BTeq	D		
]

C;kov1K}t 	P]u81g]OSZ|6W|P+ 8CTfE					

WGv1;K}@Q^8P]da-]Oo  q	}3	.	
|KMhe v]jgl			e*,,/sTD   ,
~yf  s*L.dq1k-Nf%>J\.J			



R?`jT{5v=fJPVl0ct{Y^@]~Se	
YhqN#LG   L      D7zXZ  ִF !   t/] ˇf{3(1v%f M*	mj)p80*jBJA>f"AvӒp&s{3Th$h|=27|r6
ͽ;29SNx*mq:Mҁ-76)_g+TST~6n]JHbG>83ֶ$ep-:ݨtc> @"JY.LږiHRf_0{3BWP7GPR&҇!wIYIsCKjvdt
IU"Z0]2<;e^#<Srsa-PI(B!@/vW4TO-1~Lu"M1/.mpL}qt[Px`~CA:-vk+2ANkitj^ZB.Ci[oM<YSj>;b I[6}Y쩿' gѧ-WBM-9=j9y	鰧T=/BdprO:+TGf5i&GNa;y~_j.`507j|<@b{HAx<	k1!G#1g]s.Xƺ:oXDE6c$6hnY^av5H'B-$LįXrE6""cj-;Ϗ"Ar9"] w1@
1>	jYbz   Ab8E3`   0Jg    YZ   T       K            `yaPAuAuAk,{Ĺ           o   o   w   w   T                                                                                      H7zXZ  ִF !   t/#] 3D].?I*ә_.ZvќP,Vj,ު~mC<ґ?vd;!U''yzYl.vU[Qec <L3cGq~=X?r+<ɵؿĊG]1|=ty?izd@Pp:_x3Η[r`C^
ό;SaisSmJQ9L1'ȴ.Hۡ{.Yɍފ\-Au LiYIۼ(RB6BE>Mb<#Fq?du[CdSYB{[6t+M\U1Oz〇Â*ݸ{E#T[mGU٢<[|ϪR}toMSmXK	(@F^ɦXUޚG9ωvyD^nbp%$+cVp*>e*ئHG`$0HÖ)f~4Wns׶"6$8C~)Pϐe z {i3ߪty_@6 UUe*P4g~;}lu4m\%_ZDm`Rjyvm/I*7ueKd[UF2e2(d 0#W7Ckz$k^jgѾP.<|o52փώp$E0=!nϰ`דuH	}dS{"=+pF<Fx+y+Nr=gwf>i?hW C@n-+σXDuW	8O/
l׻ԗOhlzkGN:!F$+UeZ6sz=ď+I@3	Yn XХOKS*[1WWag(bd/\6n2:s̨)_9?eQ
09ʀnĵ>37Zq9z'+3obw3+U~s>'=*VrMncņhRdye=U͑YL۩VSCzmQr=2$h7Q^D/:l):@r^һ]W2n=x!Cednl	&8oګK#Hil'۬Wzis2*.E4rʗ:j ڎqPCxg:*蘞kL&MNPWe)_lk'ɢmmöZoSތRL0_bƦwK +ۖZ8ȝ0-n~V%$qHVAoCbcOQK|zbwq%>t$XaZO!ƐP_[ h*F5+$j׹Y5	WMސɌfsهA5>7j{Sʯ~"yl5k14cIr+]/{s703L;><`@S;"&:&ûc<Eכǚ7˂ Mn2<'}jJڰ+A{2T]pެ3ߦʘ؆혛ZkGq>7EWVuzã(%<`qsurln}з`HE|Fz/җᡩ~-5гYEU7᫣>Hr]G+1YwChjxZ׃&ޡiGSʼ}vΆ
FHU cvTB$ɜfdO	N
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`JꛑV7K^ȝ&؋Lݮb?jx{nd<,6 7Iz G  Yg    YZ        ZTR

BASE      (  xA 0:-Mަ*ZnJ5Ī$VGP"(V&isldf̙KcRjknnIZi)nI%嶕RFI`J InVH4eP2Xrel%9VAH+g)6)YՔ9Mdea,Ɇ:c bb[Z-JWPsf%R6J͊QY,pʀ%f[V* "U-X(sSBr3LYf3\mkR+dYV,֖)b(jVڒIj)3P6Z̙J`U`44D):̭2f 2][VJQtpc$m faDdb'V:m[l-w܂4VJSJ@T*m[fnM  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  L      D7zXZ  ִF !   t/] ˇf{3(1v%f M*	mj)p80*jBJA>f"AvӒp&s{3Th$h|=27|r6
ͽ;29SNx*mq:Mҁ-76)_g+TST~6n]JHbG>83ֶ$ep-:ݨtc> @"JY.LږiHRf_0{3BWP7GPR&҇!wIYIsCKjvdt
IU"Z0]2<;e^#<Srsa-PI(B!@/vW4TO-1~Lu"M1/.mpL}qt[Px`~CA:-vk+2ANkitj^ZB.Ci[oM<YSj>;b I[6}Y쩿' gѧ-WBM-9=j9y	鰧T=/BdprO:+TGf5i&GNa;y~_j.`507j|<@b{HAx<	k1!G#1g]s.Xƺ:oXDE6c$6hnY^av5H'B-$LįXrE6""cj-;Ϗ"Ar9"] w1@
1>	jYbz   Ab8E3`   0Jg    YZ   T       K            `yaPAuAuAk,{Ĺ           o   o   w   w   T                                                                                      H7zXZ  ִF !   t/#] 3D].?I*ә_.ZvќP,Vj,ު~mC<ґ?vd;!U''yzYl.vU[Qec <L3cGq~=X?r+<ɵؿĊG]1|=ty?izd@Pp:_x3Η[r`C^
ό;SaisSmJQ9L1'ȴ.Hۡ{.Yɍފ\-Au LiYIۼ(RB6BE>Mb<#Fq?du[CdSYB{[6t+M\U1Oz〇Â*ݸ{E#T[mGU٢<[|ϪR}toMSmXK	(@F^ɦXUޚG9ωvyD^nbp%$+cVp*>e*ئHG`$0HÖ)f~4Wns׶"6$8C~)Pϐe z {i3ߪty_@6 UUe*P4g~;}lu4m\%_ZDm`Rjyvm/I*7ueKd[UF2e2(d 0#W7Ckz$k^jgѾP.<|o52փώp$E0=!nϰ`דuH	}dS{"=+pF<Fx+y+Nr=gwf>i?hW C@n-+σXDuW	8O/
l׻ԗOhlzkGN:!F$+UeZ6sz=ď+I@3	Yn XХOKS*[1WWag(bd/\6n2:s̨)_9?eQ
09ʀnĵ>37Zq9z'+3obw3+U~s>'=*VrMncņhRdye=U͑YL۩VSCzmQr=2$h7Q^D/:l):@r^һ]W2n=x!Cednl	&8oګK#Hil'۬Wzis2*.E4rʗ:j ڎqPCxg:*蘞kL&MNPWe)_lk'ɢmmöZoSތRL0_bƦwK +ۖZ8ȝ0-n~V%$qHVAoCbcOQK|zbwq%>t$XaZO!ƐP_[ h*F5+$j׹Y5	WMސɌfsهA5>7j{Sʯ~"yl5k14cIr+]/{s703L;><`@S;"&:&ûc<Eכǚ7˂ Mn2<'}jJڰ+A{2T]pެ3ߦʘ؆혛ZkGq>7EWVuzã(%<`qsurln}з`HE|Fz/җᡩ~-5гYEU7᫣>Hr]G+1YwChjxZ׃&ޡiGSʼ}vΆ
FHU cvTB$ɜfdO	N
6=yY͎0,fH9h>I}k2(`وuQmh5LJYaGC
`JꛑV7K^ȝ&؋Lݮb?jx{nd<,6 7Iz G  Yg    YZ  7zXZ  ִF !   t/!O] ˇf{3(1v%f M*	mj)p80*i	NY]QF7&!~g؋H8Z:bvb}B'P/9DOgdOi&;U00#^:0uda|7K!RoM$鷮rg<ЙR;$I]VD'~3Ypv\0+oz\ƣnGH!O`Lx o֑oo$I4*	TktP[㓍K6nA@gKU@jX	fmyyҍP2D0CgzGҰpwu)TpOA'%N{xd)Zճ<?+An=`  7fmJPU5Ѵa.61ӉLl^{bra*v֤]1ʺ޸èhAHcdF.MaY@q@X;3*GE9͉Ah	H(y\HLʯf	[YH.J&K1IIuꗗ U$ R=~ μ'nM[8K}F)aSG4!(Ur\0(NX_vR H[5rS:UrPݶwcz^D GQLh̼5}P8{׎XTM4zgvl+TA(0\${ƔR<u]*_ Y#Sم_00oS-,D3T*-}]Wy;^AzցmgI}]3%MAylj!t@#m q⟖\Duȃ`VJbW\)DF~$#C}R 	j+EtoW!Ư2gAEO񘸖~űxI|0 QUAE\zOCJȒ58wF'\pϮrXl92,Įq%:sp9:E% ӾT*;6VikqV0W"v:ٚk (/1cF[c.>L0DMxuPkيhwW츦^iz.09T.N/uBw}|$Ul\oKxT&6(6#`zr&n7PmEC(iIKoMX_cc!>6YAZh6YŔG/U
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
BASE      %  xA 0:-M 1i1"1i1"f3m$f"Lbm2ИNȶn[`aK$IT%Hj"	-dtBk[
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Y$ Wڢ-m\4XSp9A.EVJM)ZܖB,-ZYԒYÕ۔PL8lj+Q]˵kNLM֖h\ŬJ`J認mn47Yt+MWMW4m2aJd6[m2MSCWaRmRih,Md$m3a.Uk6Mͅ+Httm	ken*`R@I\M Vr45\bm  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>   <AlignableSequences trimStringency="Medium"><Sequence name="26388_248" ID="0" use="0" sortOrder="0" trimmedRange="11..1314"/><Sequence name="26388_269" ID="1" sortOrder="1" trimmedRange="9..1315"/></AlignableSequences>  =      BC M sre```pp23*+/*IMbqqQjZjQj^r*Ur P6         BC V?E"E<b2t5DpbJ
!8 G\"@4}?X߼G|]{u{y/+~5ON;0t~'lQ;ĦܥfŜ"a-)D;?t=C5"=\SG[٠HLq5+B"yҩvp})aӶtcMZHLrcՒhb+jK.m&);Y\8x.5t4ę7ع4ldszGMx͊nD!B=#<v=fǳ*6LWB>6
w-=,)nC{[{4Ps-tRܼ{;RJ[T;R-L-xҕ8M@A/ǝ1]<ceaKd# 
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IDupOb3I	O'ą{=:hd^~O9!	6˛&8]eHl{k:n`GB,br7>	|19;AY%	
trW)Z>fDkn`; rɔdʿ.S0,	jfy4]t"AI)RN"_.\p?K9        BC             !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
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2μ plasmid&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;FLP-mediated recombination occurs in the 8-bp core sequence TCTAGAAA (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot;&gt;Turan and Bode, 2011&lt;/a&gt;).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="4248-4254" color="#ffffff" type="standard"/><Segment range="4255-4272" color="#ffffff" type="standard"/><Segment name="-35" range="4273-4278" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4293-4314" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="820-838" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="841-859" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4200-4216" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4224-4240" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-β-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="ex1 KO as A" directionality="1" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="993-1376" color="#333399" type="standard"/></Feature><Feature recentID="16" name="PPM1H mRNA" directionality="1" type="mRNA" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="993-1376" color="#a6acb3" type="standard"/><Q name="db_xref"><V text="57460" predef="GeneID"/><V text="HGNC:18583" predef="HGNC"/><V text="616016" predef="MIM"/></Q><Q name="gene"><V text="PPM1H"/></Q><Q name="gene_synonym"><V text="ARHCL1; NERPP-2C; URCC2"/></Q><Q name="note"><V text="Derived by automated computational analysis using&#10;gene prediction method: Gnomon. Supporting evidence includes similarity to: 2 mRNAs, 9 ESTs, 5 long SRA reads, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 11 samples with support for all annotated introns"/><V text="/transcript_id=XM_017019676.2"/></Q><Q name="product"><V text="protein phosphatase, Mg2+/Mn2+ dependent 1H,&#10;transcript variant X2"/></Q></Feature><Feature recentID="17" name="PPM1H mRNA" directionality="1" type="mRNA" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="993-1376" color="#a6acb3" type="standard"/><Q name="db_xref"><V text="57460" predef="GeneID"/><V text="HGNC:18583" predef="HGNC"/><V text="616016" predef="MIM"/></Q><Q name="gene"><V text="PPM1H"/></Q><Q name="gene_synonym"><V text="ARHCL1; NERPP-2C; URCC2"/></Q><Q name="note"><V text="Derived by automated computational analysis using&#10;gene prediction method: BestRefSeq."/><V text="/transcript_id=NM_020700.1"/></Q><Q name="product"><V text="protein phosphatase, Mg2+/Mn2+ dependent 1H"/></Q></Feature><Feature recentID="18" name="PPM1H" directionality="1" type="gene" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="993-1376" color="#a6acb3" type="standard"/><Q name="db_xref"><V text="57460" predef="GeneID"/><V text="HGNC:18583" predef="HGNC"/><V text="616016" predef="MIM"/></Q><Q name="gene"><V text="PPM1H"/></Q><Q name="gene_synonym"><V text="ARHCL1; 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BUB1L; hBUB1"/></Q><Q name="note"><V text="BUB1 mitotic checkpoint serine/threonine kinase;&#10;Derived by automated computational analysis using gene prediction method: BestRefSeq,Gnomon."/></Q></Feature><Feature recentID="28" name="BUB1 mRNA" directionality="1" type="mRNA" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="1392-2279" color="#a6acb3" type="standard"/><Q name="db_xref"><V text="699" predef="GeneID"/><V text="HGNC:1148" predef="HGNC"/><V text="602452" predef="MIM"/></Q><Q name="gene"><V text="BUB1"/></Q><Q name="gene_synonym"><V text="BUB1A; BUB1L; hBUB1"/></Q><Q name="note"><V text="Derived by automated computational analysis using&#10;gene prediction method: BestRefSeq."/><V text="/transcript_id=NM_001278616.2"/></Q><Q name="product"><V text="BUB1 mitotic checkpoint serine/threonine kinase, transcript variant 2"/></Q></Feature><Feature recentID="29" name="BUB1 mRNA" directionality="1" type="mRNA" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="1392-2279" color="#a6acb3" type="standard"/><Q name="db_xref"><V text="699" predef="GeneID"/><V text="HGNC:1148" predef="HGNC"/><V text="602452" predef="MIM"/></Q><Q name="gene"><V text="BUB1"/></Q><Q name="gene_synonym"><V text="BUB1A; BUB1L; hBUB1"/></Q><Q name="note"><V text="Derived by automated computational analysis using&#10;gene prediction method: BestRefSeq."/><V text="/transcript_id=NM_001278617.2"/></Q><Q name="product"><V text="BUB1 mitotic checkpoint serine/threonine kinase, transcript variant 3"/></Q></Feature><Feature recentID="30" name="BUB1 mRNA" directionality="1" type="mRNA" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="1392-2279" color="#a6acb3" type="standard"/><Q name="db_xref"><V text="ENST00000302759.11" predef="Ensembl"/><V text="699" predef="GeneID"/><V text="HGNC:1148" predef="HGNC"/><V text="602452" predef="MIM"/></Q><Q name="gene"><V text="BUB1"/></Q><Q name="gene_synonym"><V text="BUB1A; BUB1L; hBUB1"/></Q><Q name="note"><V text="Derived by automated computational analysis using&#10;gene prediction method: BestRefSeq."/><V text="/transcript_id=NM_004336.5"/></Q><Q name="product"><V text="BUB1 mitotic checkpoint serine/threonine kinase, transcript variant 1"/></Q></Feature><Feature recentID="31" name="BUB1 mRNA" directionality="1" type="mRNA" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="1392-2279" color="#a6acb3" type="standard"/><Q name="db_xref"><V text="699" predef="GeneID"/><V text="HGNC:1148" predef="HGNC"/><V text="602452" predef="MIM"/></Q><Q name="gene"><V text="BUB1"/></Q><Q name="gene_synonym"><V text="BUB1A; BUB1L; hBUB1"/></Q><Q name="note"><V text="Derived by automated computational analysis using&#10;gene prediction method: Gnomon. 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  Y     K         Unique 6+ Cutters                                                                                            d     CHO  d             E             Y? P                                                                                                                                                              3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
