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S +etY		b" PNx#	   NhS8B}[


$6LU $^l_*	Y%h#  U 4Id(wg	U!  fgv{|^)	XgRSTIJK  -  GACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GCACNNNNNNGTTSAACNNNNNNGTGC,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNNNNTTYG,CRAANNNNNNGTC,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,TCGGTC,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,TTSAA,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GCTCC,GGAGC,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,CCDG,CHGG,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                                    %                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        	                
                            	                                                                                                                                                                     
                                                             	                                                                                       	                                                                              
            
                  %      
   
   	   	               	                         	                              
                                       %   "                '            c   M         Y   N               N                                                                                                                                                                         %                                                                                                                                                                                                                                                                                                    	      
            	                                                               
                       	                               	                            
    
      %  
 
 	 	     	         	          
             % "      '    c M   Y N     N   iU  j]  ju  j  n+  r  y/vl
$tg[

&h(~?4J l	y"s	XM	>S/>S	*s
t Mkr.4qsM




\w ,5q}	N~+N~N~NNb-{! 
hh   9;\ 4~@v	*r	]a
z_
La	O	od	Q

0e~ 9-r	c   -c%
@ %
@S5  [. %5
@	-c5*N	
3Z1Gi
t C5
		$KOAvp
KF	aS	
Ht&Wa
zgo]
Q

0hJ6GQ



0W	a
  -c%5*N
@a	
w Mw]c
#5R:ja
HK C VS1(S<'<N-cA-]oE ]  ]n%#C	
@(   k		Z
a
@z6Bu9  	|a ]CH
TZO
HT]pvs	 :)) "CvLa k	  CU =8vR~h!	 	


\V\n$ Lk569/ST	9e@<	]N	?k9	
\n$ 

V\h#B=?	&
r>	
G2;  n|	
S



\/V2\n	$hR~/STh	!9M

w2^z28 h3"	
LOUe
ZI  >'R	2.!
xo$C& Xl 8t1VLCrSm|'69& l  8
Xt:OITdS1(bcl	NhB

$6
o L	^
&!ay~\_^	bk5 v~7	[				sv%2sY"2]R X
L/Y}7e
 k9W :?
	4:=,y~
W L	^
&!a; n|S

/2	h:OTdS1I( _Cm Ev   4c{	U

Kd.ln4y< 3O[iC	T


%73OZO
ik	"(%=n|


 q/oyX*  #Dw%I	Mb .dI		
U56?u  dqz!
V
Je-,m_z` s]SM	l	\A   DYy2CsH	5


U =^* L6	R


F1f1/T^b

{	h@9 &bp
8[>G    "LU.db\`6Lf+3IO				
R




FP1AUf1K5:S6? ?   &(*;&.b#%o/Mp0t	
;

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e   &H	L




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b




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2μ plasmid&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;FLP-mediated recombination occurs in the 8-bp core sequence TCTAGAAA (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot;&gt;Turan and Bode, 2011&lt;/a&gt;).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="3810-3816" color="#ffffff" type="standard"/><Segment range="3817-3834" color="#ffffff" type="standard"/><Segment name="-35" range="3835-3840" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3855-3876" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="820-838" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="841-859" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3762-3778" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3786-3802" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-β-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="dTAG F36V" directionality="1" translationMW="11771.49" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="1844" maxFusedRunOn="1844"><Segment range="993-1313" color="#993300" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;L106P mutant of FKBP12&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;destabilization domain that can be stabilized by Shield1 in the ProteoTuner™ system&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="GVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKVDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE"/></Q></Feature><Feature recentID="16" name="ex1 KO as A" directionality="1" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="993-1313" color="#333399" type="standard"/></Feature><Feature recentID="17" name="PPM1H mRNA" directionality="1" type="mRNA" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="993-1313" color="#a6acb3" type="standard"/><Q name="db_xref"><V text="57460" predef="GeneID"/><V text="HGNC:18583" predef="HGNC"/><V text="616016" predef="MIM"/></Q><Q name="gene"><V text="PPM1H"/></Q><Q name="gene_synonym"><V text="ARHCL1; NERPP-2C; URCC2"/></Q><Q name="note"><V text="Derived by automated computational analysis using&#10;gene prediction method: Gnomon. Supporting evidence includes similarity to: 2 mRNAs, 9 ESTs, 5 long SRA reads, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 11 samples with support for all annotated introns"/><V text="/transcript_id=XM_017019676.2"/></Q><Q name="product"><V text="protein phosphatase, Mg2+/Mn2+ dependent 1H,&#10;transcript variant X2"/></Q></Feature><Feature recentID="18" name="PPM1H mRNA" directionality="1" type="mRNA" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="993-1313" color="#a6acb3" type="standard"/><Q name="db_xref"><V text="57460" predef="GeneID"/><V text="HGNC:18583" predef="HGNC"/><V text="616016" predef="MIM"/></Q><Q name="gene"><V text="PPM1H"/></Q><Q name="gene_synonym"><V text="ARHCL1; NERPP-2C; URCC2"/></Q><Q name="note"><V text="Derived by automated computational analysis using&#10;gene prediction method: BestRefSeq."/><V text="/transcript_id=NM_020700.1"/></Q><Q name="product"><V text="protein phosphatase, Mg2+/Mn2+ dependent 1H"/></Q></Feature><Feature recentID="19" name="PPM1H" directionality="1" type="gene" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="993-1313" color="#a6acb3" type="standard"/><Q name="db_xref"><V text="57460" predef="GeneID"/><V text="HGNC:18583" predef="HGNC"/><V text="616016" predef="MIM"/></Q><Q name="gene"><V text="PPM1H"/></Q><Q name="gene_synonym"><V text="ARHCL1; NERPP-2C; URCC2"/></Q><Q name="note"><V text="protein phosphatase, Mg2+/Mn2+ dependent 1H;&#10;Derived by automated computational analysis using gene prediction method: BestRefSeq,Gnomon."/></Q></Feature><Feature recentID="20" name="source" type="source" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="993-1313" color="#ffffff" type="standard"/><Q name="chromosome"><V text="12"/></Q><Q name="db_xref"><V text="9606" predef="taxon"/></Q><Q name="mol_type"><V predef="genomic DNA"/></Q><Q name="organism"><V text="Homo sapiens"/></Q></Feature><Feature recentID="21" name="Nter KI as A" directionality="1" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="993-1313" color="#ffcc00" type="standard"/></Feature><Feature recentID="22" name="L106" type="unsure" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1308-1310" color="#a6acb3" type="standard"/></Feature><Feature recentID="23" name="F36V" type="unsure" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1098-1100" color="#a6acb3" type="standard"/></Feature><Feature recentID="24" name="Nluc" directionality="1" translationMW="19094.99" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1844" maxFusedRunOn="1844"><Segment range="1329-1841" color="#00ccff" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;NanoLuc® luciferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MVFTLEDFVGDWRQTAGYNLDQVLEQGGVSSLFQNLGVSVTPIQRIVLSGENGLKIDIHVIIPYEGLSGDQMGQIEKIFKVVYPVDDHHFKVILHYGTLVIDGVTPNMIDYFGRPYEGIAVFDGKKITVTGTLWNGNKIIDERLINPDGSLLFRVTINGVTGWRLCERILA"/></Q></Feature><Feature recentID="25" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1329-1332" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="26" name="linker" directionality="1" translationMW="303.27" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1844" maxFusedRunOn="1844"><Segment range="1314-1328" color="#99ccff" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="GGGGG"/></Q></Feature><Feature recentID="27" name="Met" type="unsure" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="990-992" color="#339966" type="standard"/></Feature></Features>
  
<?xml version="1.0"?><Primers nextValidID="4"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40" showAdditionalFivePrimeMatches="1" minimumFivePrimeAnnealing="15"/><Primer recentID="0" name="KLD F" sequence="TTCGTGACCGCCGCCGGGATCACTGGAGTGCAGGTGGAAACCATCTCC" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" visible="0"><BindingSite location="992-1015" boundStrand="0" annealedBases="GGAGTGCAGGTGGAAACCATCTCC" meltingTemperature="63"><Component bases="TTCGTGACCGCCGCCGGGATCACT"/><Component hybridizedRange="992-1015" bases="GGAGTGCAGGTGGAAACCATCTCC"/></BindingSite><BindingSite simplified="1" location="992-1015" boundStrand="0" annealedBases="GGAGTGCAGGTGGAAACCATCTCC" meltingTemperature="63"><Component bases="TTCGTGACCGCCGCCGGGATCACT"/><Component hybridizedRange="992-1015" bases="GGAGTGCAGGTGGAAACCATCTCC"/></BindingSite></Primer><Primer recentID="1" name="ins fa" sequence="ggagcgggtgctggagcaggtgcgGGAGTGCAGGTGGAAACCATCTCC" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2023-02-22T14:06:58Z" visible="0"><BindingSite location="991-1015" boundStrand="0" annealedBases="gGGAGTGCAGGTGGAAACCATCTCC" meltingTemperature="65"><Component bases="ggagcgggtgctggagcaggtgc"/><Component hybridizedRange="991-1015" bases="gGGAGTGCAGGTGGAAACCATCTCC"/></BindingSite><BindingSite simplified="1" location="991-1015" boundStrand="0" annealedBases="gGGAGTGCAGGTGGAAACCATCTCC" meltingTemperature="65"><Component bases="ggagcgggtgctggagcaggtgc"/><Component hybridizedRange="991-1015" bases="gGGAGTGCAGGTGGAAACCATCTCC"/></BindingSite></Primer><Primer recentID="2" name="dTAG seq F" sequence="GAGTGTGGGTCAGAGAGC" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2023-09-15T09:19:45Z"><BindingSite location="1189-1206" boundStrand="0" annealedBases="GAGTGTGGGTCAGAGAGC" meltingTemperature="57"><Component hybridizedRange="1189-1206" bases="GAGTGTGGGTCAGAGAGC"/></BindingSite><BindingSite simplified="1" location="1189-1206" boundStrand="0" annealedBases="GAGTGTGGGTCAGAGAGC" meltingTemperature="57"><Component hybridizedRange="1189-1206" bases="GAGTGTGGGTCAGAGAGC"/></BindingSite></Primer><Primer recentID="3" name="NLuc C-out" sequence="acgagcgcctgatcaacc" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2023-11-23T11:16:12Z"><BindingSite location="1749-1766" boundStrand="0" annealedBases="acgagcgcctgatcaacc" meltingTemperature="60"><Component hybridizedRange="1749-1766" bases="acgagcgcctgatcaacc"/></BindingSite><BindingSite simplified="1" location="1749-1766" boundStrand="0" annealedBases="acgagcgcctgatcaacc" meltingTemperature="60"><Component hybridizedRange="1749-1766" bases="acgagcgcctgatcaacc"/></BindingSite></Primer></Primers>
  `<Notes>
<UUID>1cf551b6-0306-4c22-a78f-1432fb326a7e</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="0:0:0">2016.12.16</Created>
<LastModified UTC="14:33:27">2025.7.24</LastModified>
<CreatedBy>MRC PPU</CreatedBy>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         Unique 6+ Cutters                                                                                            d     CHO  d             E             Y? P                                                                                                                                                              3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
