	   SnapGene      gacggatcgggagatctcccgatcccctatggtgcactctcagtacaatctgctctgatgccgcatagttaagccagtatctgctccctgcttgtgtgttggaggtcgctgagtagtgcgcgagcaaaatttaagctacaacaaggcaaggcttgaccgacaattgcatgaagaatctgcttagggttaggcgttttgcgctgcttcgcgatgtacgggccagatatacgcgttgacattgattattgactagttattaatagtaatcaattacggggtcattagttcatagcccatatatggagttccgcgttacataacttacggtaaatggcccgcctggctgaccgcccaacgacccccgcccattgacgtcaataatgacgtatgttcccatagtaacgccaatagggactttccattgacgtcaatgggtggagtatttacggtaaactgcccacttggcagtacatcaagtgtatcatatgccaagtacgccccctattgacgtcaatgacggtaaatggcccgcctggcattatgcccagtacatgaccttatgggactttcctacttggcagtacatctacgtattagtcatcgctattaccatggtgatgcggttttggcagtacatcaatgggcgtggatagcggtttgactcacggggatttccaagtctccaccccattgacgtcaatgggagtttgttttggcaccaaaatcaacgggactttccaaaatgtcgtaacaactccgccccattgacgcaaatgggcggtaggcgtgtacggtgggaggtctatataagcagagctctccctatcagtgatagagatctccctatcagtgatagagatcgtcgacgagctcgtttagtgaaccgtcagatcgcctggagacgccatccacgctgttttgacctccatagaagacaccgggaccgatccagcctccggactctagcgtttaaacttaagcttggtaccgagctcggatctgccgccatggcagaaatcggtactggctttccattcgacccccattatgtggaagtcctgggcgagcgcatgcactacgtcgatgttggtccgcgcgatggcacccctgtgctgttcctgcacggtaacccgacctcctcctacgtgtggcgcaacatcatcccgcatgttgcaccgacccatcgctgcattgctccagacctgatcggtatgggcaaatccgacaaaccagacctgggttatttcttcgacgaccacgtccgcttcatggatgccttcatcgaagccctgggtctggaagaggtcgtcctggtcattcacgactggggctccgctctgggtttccactgggccaagcgcaatccagagcgcgtcaaaggtattgcatttatggagttcatccgccctatcccgacctgggacgaatggccagaatttgcccgcgagaccttccaggccttccgcaccaccgacgtcggccgcaagctgatcatcgatcagaacgtttttatcgagggtacgctgccgatgggtgtcgtccgcccgctgactgaagtcgagatggaccattaccgcgagccgttcctgaatcctgttgaccgcgagccactgtggcgcttcccaaacgagctgccaatcgccggtgagccagcgaacatcgtcgcgctggtcgaagaatacatggactggctgcaccagtcccctgtcccgaagctgctgttctggggcaccccaggcgttctgatcccaccggccgaagccgctcgcctggccaaaagcctgcctaactgcaaggctgtggacatcggcccgggtctgaatctgctgcaagaagacaacccggacctgatcggcagcgagatcgcgcgctggctgtctacgctagagatttccggcctggaagttctgttccaggggcctggatccatggcggcagatggagagcgttccccgctgctgtctgagcccatcgacggtggcgcgggcggcaacggtttagtggggcccggcgggagtggggctgggcccgggggaggcctgaccccctccgcaccaccgtacggagccggtaaacatgccccgccccaggcatttcccccgtttcccgaggggcatccagccgtgttgcctggggaggacccacccccctattcacccttaactagcccggacagtgggagtgcccctatgatcacctgccgagtctgccaatctctcatcaacgtggaaggcgagatgcatcagcatgtagtcaaatgtggtgtctgcaatgaagccaccccaatcaagaatgcacccccagggaaaaaatatgttcgatgcccctgtaactgtctccttatctgcaaagtgacatcccaacggattgcatgccctcggccctactgcaaaagaatcatcaacctggggcctgtgcatcccggacctctgagtccagaaccccaacccatgggtgtcagggttatctgtggacattgcaagaatacttttctgtggacagagttcacagaccgcactttggcacgttgtcctcactgcaggaaagtgtcatctattgggcgcagatacccacgtaagagatgtatctgctgcttcttgcttggcttgcttttggcagtcactgccactggccttgcctttggcacatggaagcatgcacggcgatatggaggcatctatgcagcctgggcatttgtcatcctgttggctgtgctgtgtttgggccgggctctttattgggcctgtatgaaggtcagccaccctgtccagaacttctcctgagcggccgcttacccatacgatgtgccagattacgcctaagtcgagtctagagggcccgtttaaacccgctgatcagcctcgactgtgccttctagttgccagccatctgttgtttgcccctcccccgtgccttccttgaccctggaaggtgccactcccactgtcctttcctaataaaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctggggggtggggtggggcaggacagcaagggggaggattgggaagacaatagcaggcatgctggggatgcggtgggctctatggcttctgaggcggaaagaaccagctggggctctagggggtatccccacgcgccctgtagcggcgcattaagcgcggcgggtgtggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcccgctcctttcgctttcttcccttcctttctcgccacgttcgccggctttccccgtcaagctctaaatcgggggctccctttagggttccgatttagtgctttacggcacctcgaccccaaaaaacttgattagggtgatggttcacgtacctagaagttcctattccgaagttcctattctctagaaagtataggaacttccttggccaaaaagcctgaactcaccgcgacgtctgtcgagaagtttctgatcgaaaagttcgacagcgtctccgacctgatgcagctctcggagggcgaagaatctcgtgctttcagcttcgatgtaggagggcgtggatatgtcctgcgggtaaatagctgcgccgatggtttctacaaagatcgttatgtttatcggcactttgcatcggccgcgctcccgattccggaagtgcttgacattggggagttcagcgagagcctgacctattgcatctcccgccgtgcacagggtgtcacgttgcaagacctgcctgaaaccgaactgcccgctgttctgcagccggtcgcggaggccatggatgcgatcgctgcggccgatcttagccagacgagcgggttcggcccattcggaccgcaaggaatcggtcaatacactacatggcgtgatttcatatgcgcgattgctgatccccatgtgtatcactggcaaactgtgatggacgacaccgtcagtgcgtccgtcgcgcaggctctcgatgagctgatgctttgggccgaggactgccccgaagtccggcacctcgtgcacgcggatttcggctccaacaatgtcctgacggacaatggccgcataacagcggtcattgactggagcgaggcgatgttcggggattcccaatacgaggtcgccaacatcttcttctggaggccgtggttggcttgtatggagcagcagacgcgctacttcgagcggaggcatccggagcttgcaggatcgccgcggctccgggcgtatatgctccgcattggtcttgaccaactctatcagagcttggttgacggcaatttcgatgatgcagcttgggcgcagggtcgatgcgacgcaatcgtccgatccggagccgggactgtcgggcgtacacaaatcgcccgcagaagcgcggccgtctggaccgatggctgtgtagaagtactcgccgatagtggaaaccgacgccccagcactcgtccgagggcaaaggaatagcacgtactacgagatttcgattccaccgccgccttctatgaaaggttgggcttcggaatcgttttccgggacgccggctggatgatcctccagcgcggggatctcatgctggagttcttcgcccaccccaacttgtttattgcagcttataatggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttatcatgtctgtataccgtcgacctctagctagagcttggcgtaatcatggtcatagctgtttcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccggaagcataaagtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgccagctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtattgggcgctcttccgcttcctcgctcactgactcgctgcgctcggtcgttcggctgcggcgagcggtatcagctcactcaaaggcggtaatacggttatccacagaatcaggggataacgcaggaaagaacatgtgagcaaaaggccagcaaaaggccaggaaccgtaaaaaggccgcgttgctggcgtttttccataggctccgcccccctgacgagcatcacaaaaatcgacgctcaagtcagaggtggcgaaacccgacaggactataaagataccaggcgtttccccctggaagctccctcgtgcgctctcctgttccgaccctgccgcttaccggatacctgtccgcctttctcccttcgggaagcgtggcgctttctcatagctcacgctgtaggtatctcagttcggtgtaggtcgttcgctccaagctgggctgtgtgcacgaaccccccgttcagcccgaccgctgcgccttatccggtaactatcgtcttgagtccaacccggtaagacacgacttatcgccactggcagcagccactggtaacaggattagcagagcgaggtatgtaggcggtgctacagagttcttgaagtggtggcctaactacggctacactagaagaacagtatttggtatctgcgctctgctgaagccagttaccttcggaaaaagagttggtagctcttgatccggcaaacaaaccaccgctggtagcggtggtttttttgtttgcaagcagcagattacgcgcagaaaaaaaggatctcaagaagatcctttgatcttttctacggggtctgacgctcagtggaacgaaaactcacgttaagggattttggtcatgagattatcaaaaaggatcttcacctagatccttttaaattaaaaatgaagttttaaatcaatctaaagtatatatgagtaaacttggtctgacagttaccaatgcttaatcagtgaggcacctatctcagcgatctgtctatttcgttcatccatagttgcctgactccccgtcgtgtagataactacgatacgggagggcttaccatctggccccagtgctgcaatgataccgcgagacccacgctcaccggctccagatttatcagcaataaaccagccagccggaagggccgagcgcagaagtggtcctgcaactttatccgcctccatccagtctattaattgttgccgggaagctagagtaagtagttcgccagttaatagtttgcgcaacgttgttgccattgctacaggcatcgtggtgtcacgctcgtcgtttggtatggcttcattcagctccggttcccaacgatcaaggcgagttacatgatcccccatgttgtgcaaaaaagcggttagctccttcggtcctccgatcgttgtcagaagtaagttggccgcagtgttatcactcatggttatggcagcactgcataattctcttactgtcatgccatccgtaagatgcttttctgtgactggtgagtactcaaccaagtcattctgagaatagtgtatgcggcgaccgagttgctcttgcccggcgtcaatacgggataataccgcgccacatagcagaactttaaaagtgctcatcattggaaaacgttcttcggggcgaaaactctcaaggatcttaccgctgttgagatccagttcgatgtaacccactcgtgcacccaactgatcttcagcatcttttactttcaccagcgtttctgggtgagcaaaaacaggaaggcaaaatgccgcaaaaaagggaataagggcgacacggaaatgttgaatactcatactcttcctttttcaatattattgaagcatttatcagggttattgtctcatgagcggatacatatttgaatgtatttagaaaaataaacaaataggggttccgcgcacatttccccgaaaagtgccacctgacgtc  ;   "         '                           (   #      '            !   '                     '            #                                     $               !         (   #   "   #      0      $   +   $   '   !   (                                                                  /                                 &                                    "   "   !                            	      
                     *   "      *            !                  )       (                                                   !         "                        '            ,                     !      '            %           "            !                            "      -   '            '      "               !   '               -   #   *   .                                     %   !   #      8   '            3            &   &      3        " .{>Tg	*34QN  1UR!OyP  ;		5^*'  $/F|?h		



+tUd}X 	 d -qVm
S 6PZPz l 		Y
nUA9\"9Qa  <	dd 2	3Yzw			Ri  ek	r_dX7^:+ Edc6Ga1q  m<	g)AX: g @ 
(  %}N	e
M[uUe[zbxY#  @sL=)@	6
R
p

"ESVy,V =  U0P+


,p-n(~v'  LGg}K	i	F



`/#C e <Wn

!QSSV*{ 
 BWC^
]mQS n .r			TV!=i! y -c(W)D\n
_z7L[|9.'  (mZ

o-;B'm: 		L:#^\b  4Z		]>URj pv	
!Vm# 8  h:I	

Ow)  >S
h
3skt  `=	
;+ouQ'    DYy9E%2eepx;   r~`xS?@6I   
+{1			KVef\  3*/jk[6#  Yd)l>4Zx		hvep5e  {L		be'7?Y8\ f<Qnl/	tM(4;, ] _ yK		
`;"f_Z  s Un	

3]sEy`- p H$2h' Fe	
Hb#% L Nd

7P=2xVf_r\ *  #Dw&*f? a  =;M	
=K*<TDGkg C   7	h2  ni=5
NBY};C9m$$ 0Zt.pu		 0>V,I* h ]7}hm*cj uTu!]		:


	\RaK{  T	{bQ@ A		
dOFX! k	
KY\NlLV5` w  &G'BtAf
v[)\9cZ   5[rbv]{y"( u  *E~MYOIK 
ANWm3'kB
	Jf<W=# At*>	
7
y
om9<az}KNY" {  O$*	T		FW	 G?0>H# >  ,i*AA	p	]
q

P*mT&46;W	 ! 0M`		S
a
#{Ib-0 k  VW
^!MQ


"'/|39.  ZZzDxP$ Y    Q 
'
,
0

G.]~pw,+ 3 R /e16
	-5qo~hx)Lfn$ ; +hH

 0v$i0~E' H  HFap@


@Dua/Ds.J! Q}h~Pj	G
L
|

 *5_ia>W( #M]k|#v	E	L	RC C.1t  z=	2T|OW X	Tc[ hc8 f b
qW    (o
o"RT'y+U< ,AVV]	
^{RU
   'Y			
 ,K&[lT   CXxD_


nrPoj( *	>e r ;Pm~.		D_6'Y ) K o "CvO)"&> B  /so	</=U;S)18j S	9

QWJ )LXs@
JVqZM	48! z )\
8;Ha%:|JM/  .d]&{\w}2 G "*EoGu{

)Ch`0   a
p Zb;NV  &)X		
qd	kn' n-		.<NC(P%I F  (K[
Ug$I `,	W		MfY#paM/ } 			V	
de	
BC]^_`23@JKL ~ H		DAc XH;J$_"&4 I{ 
~S;Bd x		^ 5V~Sk     .  Q5d[	?E# aY9	GA  w#5 >q	
WnIKJn qg.b			"<%`$\'E&  +J/cJo	W
k
P4t  |'
x<  ;		

9T`e 9 i.	C	_
w
 %|*^C @  ?TR4_%Q6W <y&!nlT  ')$	i
#z  	

htulr    of>			
Nj,aM   P]!
R8R  ka,
p(D 	$g6D<v6|N"  WZz ez:F,f@FNpY" 	{8M\	_	&?P]=$!  / N  HE&			
s
GoXfy3<   Rx6C4	r	
93VCqM!   Cb:	c
w_ ba(Z
Tk7!ir sL5w	
$ydB  X
?k@AHJUd |		}fS6 ,    , @$  :%Fyx2		U
L	 }Wg] +CI	Q		=
C
0~BJ1|v7
  2rhkKo ?4<		
X%Gl	 # xo,KL\Ant  Zr$?	wsY={j6+f `#v(F *m5c	y	(fq&/ eOh/[_k		


ia%]* 0#
-:ESf			


)Pc)" c ,pk		X
l
mQ58  d?cf(@09]p9* KT?r K|MO	*
5
E
Q

_D,Zxu m m~	
yU)<R-  o3
l=i 7  g=R8$1N~w!    Xq}(=0	guJd~5Z5 \ ^ TzKm			


2a:L!>3  	

G<1#Ue g[ ` <Y:tL
	

JMBFf S				

~Ea)?` t  j&a\;<_)    /_h#)	@	S	o			`
x
)lz`35F  2 Q X   V 

&
/

F.}O+m( : `O	D	?
K

4?Q^t.VIsD   1S& @U\+J%zi A q  Rl;5:R(7X !tI`v3 E  '
Tc$&U G"o z:"4 =fp	Im  *.n	j
v

$3{ s]  (#%Qygm   O\ef	
5Ci`C
 M 7L%		
8>W\BMo2   BK4vW

jjTqv +  9$Ex|R ;P		F+g@ms _#

'iu! b >q>		)
4
P



^O+bo     p<fITvh [ 	
L0=DAE"   gN?		%
.
J
>P(k-_[EU;HNlr   Qk D   oS9!3   -m$		
[An 8A^"

iS  p	3
O


O'CZ@Du:n  jl
  o	2
)*+,<=>?|.|}' 6>b-6	q- ~}E/%~  
	Ir	F+ %uh	!W .-Jy} q	"

8E	7~0O&, 17[?/Scv.7b17?Z= wlr!x  ;I	 -A ^8	-uJsnG [g {M+OGdZhk i  X{f~Gig.v
q, ' 9Nv	
'X]S.%6~ 
v|^`	
QNiC|! U"v]		
!N^KzLp &i		;
"q@/z>b' 0 5 O  8r'	|			
H|c=1P' I!U	t
9/H
8tA #

YjRzp	v  % 1F	
Fpsg4% 2B3yd 8>eWqPm+D"  @SwD	
xG"YN  8 \ps07!		

c2@[sry"   T 3HT/85	s	Wz:7r4^   
]s Mx  2y;	v	@OY` Dl
cjWF`6! <fJ	d

LZ!.mBaw  x b'(C[B;\	KRl8h u:]"   9H	g

:*v2t:s  c_k).wU?oHd4jd[ xJ\sx&,e[ M

%we^$   6h-4	|+HCl# t\t6\|z[cgNlPbiz" v   4DFZ&AHJ@Xlu2(jAkIKV =  +N	
OnlX>G- j  Y5	PLY
!y4C
gowK8-e' P\j|{g"
Buh/B}-=r- y'		~nbgxT7  +wU			


=TOZ ( J !Bu:O}8
^&0' r?Fz

(B%pY:G1/{~L7    J %	OHjH" | _W+	U		cGXIA!%1?I -  w}Pc
R}  `-8	a		F[@D  &b-B		V
^
8_ ? &;
"$P
q!  n#j +	
QM'57L{M' GVzwyB3	^	q		r

F+nUO<LX  a'	
b
>#c hc^ 	T
|? " 1BH		<
B
w}~$AJ0{u N^j
rXz*.- S"	,9DNjRe	D
~
l(Cw/8(# 6 l W27}	
#kc0}}4YQ* SX9JRs		l			




1IF}K d(>2. 1 P W   ^_"(	R		

>
24:  [s:0*I9uy   ["6Ke	u
4BhlL1B	  :J3uVO	{EipQ Z  =$
(
-
I
e]H/^S
q  @,n#	
Z@m  5		1
N

&t{-{   R!

7aYHkq x
w fH	,t-Lug & 	pMyMh5Bo $ 4 07{	

.Grsiou%  S 2Gor2 	
Vy6qp*]! i1exu	
?XrE_v#   j:991>Qc3g s,	3I[wZf%k*a#8 < 3O[iC4z%@!	
 xt1tj|n,7,F' I   Tqx&E	

A$F0w/ _IVb7		bHEZG %ma	
E7#O K AG]

A

v|=yt)3 V R~!R]186iQ	d	k	}




kEjb'3X  95Jt~dN	)3Ag0 +m"	H
M
6`d\?sz nqG	z		+U rt&  Nhi0 29wt	Z8sb)2^`u& $^lU%\6				

{<6E   U 4IQ}cl	F	M	
TjD23  fgP$01`ab		SXY;5D/01&'(_  1  GACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GCACNNNNNNGTTSAACNNNNNNGTGC,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNNNNTTYG,CRAANNNNNNGTC,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,TCGGTC,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,TTSAA,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GCTCC,GGAGC,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,CCDG,CHGG,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                              1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              	                                                       	                           
                                                                                                                                                                                  &                                                                                    &                                                                                                       
                     3   (         
   	                                                      
               	   
                                 "   8   !         (      '   '   !         V      )   {   d               [                                                                                                                                                                   1                                                                                                                                                                                                                                                                                  	                     	           
                                                                &                              &                                   
       3 (   
 	                  
     	 
           " 8 !   (  ' ' !   V  ) { d     [   t  vL  vl  v  {4    x	SI	|$Ctb x		D8wE[NMlJ 8
~V
Pd>>5MFx>S>Sh+Px7
 MkWFQ'
7
]
y
NPz*mb9T	]Nxx}A
{x*+[+[+[++bNX^xd	{
|  g\
 hd{Xg	~vms	Xrx]Tfm>W<)>Lr,4
LA
_.B~ 
rx@x w  -cy y9 8 y_-c/
+(,A	]
7$+C	FQNe CL0{Yg	rn(,SMhKv
#ca!x%:QG	d		}
j\%jQ4>WD	LhIo
.E'^
.4d
a	  -c/
+yfa	\iuw M&,'BpIMA	,
]
@m] /Ga	%j,A	]
K Cdo GV	<
0jy+-c
:{L
" ];m  ]n;T			 yfm   &S08	

H7>sWRi  Ya  %j17,H		%1]mMSh e) "Cv)>fH dd 2phR~!ix&Qd	}
kw	 ^!>
y
o939z}K L@F3|YK	h	w	

0wt	
r^uek:+iq@3Yw	>y
o9z}K ^!
39E IOc
+Hv$;  ^!>
y


KYo09il~39z}K`ER~!0ix&Qwd	t	}

krw^uAp	q
*mT;W8 h	)+CC
Bv7I  /wB3	q	
UL & 5l }	
Q1CrbI|	0~JYj& l  }	
5Q:O}^&BH	<
B
}A0{u?@I[byNh s\L 4Z			;u>V[\_6|wg?lHbi5 v|	8PSP6`
o:R 15o~)6Z7e	/	:
htHa4 (mj	v		V[/	:
ta4 4Z	;u>; 

KY0il~`E:OBH}	<
B
}A^0{u& 
<u Jy :	_e"v   4DFZ&AHJ@Xlu2(jAkIKV< 3O[iC4z%@!	
 xt1tj|n,7,Fk	
KY\NlLV5`*  #Dw&*f? .d]&{\w}2u  *E~MYOIK 
ANWm3'kB
	Jf<W= [s:0*I9uy   DYy9E%2eepx; LGg}K	i	F



`/#Ci1exu	
?XrE_v &b-B		V
^
8_G    "LU.d0G*E]oPg}GuK	i	+
F
{






)C&,`h/`p{#-\nw}2C(0~v ?   &(*;&.b#%-n	B		V
^
j
v


Q"$83y{_g$m Ps
]qsL5w	
$ydB   /_h#)	@	S	o			`
x
)lz`35FI V  R ~!R]T18iq16eix&EQx	d	k	u		}







Ak$Ej?bXrF'03wE_X/vS"	,9Di1Nejy'Rxe	u			D
~

l(?~CnXbrgxE_w/T8v(7   nqG	z		+U rte <Wn

!QSSV*{D   oS9!3f  s*L.d5mwb]5c	y		

q&$(yf{\dqw}&2W/B^8	-uJsnG                 `ud=&㿎,$jSuC֍
C*'љ̡hy)[Zpi+d+̧eVσYaɊ\hr%x4"m'?Xpczz'nri-}¨40{pRJUzV,^X$2'.fSDm!HdFNʒFρ8G|L^'=El'i677	ȃ5o͊76~	ռu}ܼ`clSD,kq
=LLT&+o?E~7SEʩs,F| οW[<!=1v3vS+7<=Tx8[5uLF.s>+o`FL.3p  |WcCjʿ<> AtHm.=n5M-X.5=[QcUc%To?5Qm6K-QgDzrAR-3FrQ:::=>݁M>j-(8"<hOzEN<b=s,K8m>ǈۊ*?xUl.B-k 45 hd0`0T_N @	L3iL 29ޏLL:rë;jHp߱U^!'Rk+滑RdT^1ˋJlU+24[:@VN3
)6Ƽh+LD~hۿ<"ܣQWO0C0OG5`jٌƎx5x2:K~/X<t1gnC(:&G30Col2f;͠^:
5cN1lo,ճE3."E'HPY7'Fk<
ʯL8詣N`VTMVՕ6k*/W&.&|:-"kgM"T>XHN^ݥ(?:,~,N63 D0ɠ3󯳷,8	PY\T]MT=5PU2?MUls-teF}N<gL:d$&+N|>^l%Ǧx4	tM9+H yÝQtn3OJ~UDWW8$
M4iUPnQp;H{r-iTꕥVVI.)ߛ欭"F^qn5|sýMe}=<4R^oKZ(II+=)dr=;,&
qJvbTE%(<)
`xkx=cI}KkY"c|J;Ye3ݓEU#\U(Fb_׆M}2Ut5XUPP1{gY6)Y]Y 3vT~        T      TܮZTR

SMP4      M8  xKukv9Z{9unb+N8Xq	`;H#!8X"@RҠVz=H!Ht ,w1F{pC.),׏_~W_|/_Z|S7Ho_~U'ݟٟw>=>~<hh} eYP܌5h乴׹L`i21Q:!QMp'UA?(jD[8&XIٝkO	99*4UT߆e|蛷"2	LjPb
mzEhٍB`"?\w9e[nz>L8Y,ᒚ>Ia		CgHrv|SDt?[W]5\g9F@YK>n11T2%ʒy<ZyHU5f}%,FP6SyR;P?Ayо?1Z+QstlReʜsc{{8o%3/֕d]e{Rzz-ic+prw=hr쎒AnzX_ʇ5Wr:)-	}oQ0\Bniܟg\>lqv^qҪP5{
`)_2prn#Mhϝ"_ٓ"e͓NmF(aepK4a1`r7(Kg̔r
y8RLpR=uK<~Rf[Z㹣|b𼬡SS=eiXs78Tmst^
t얟/o?:c'+߃>}(AcJ2Q]CXvұ%FsNF6fY~-T<v,"QmSyfQ9SNȴ1oB穲r|[0GSIHa]Ֆ՞6m-d[!bfȟe˶\^.ԎOv[2 B{~O\HEh-H;)Ǥ<XMr峽?m!r1h lk)ɔsj,/'[0_á'</[v[ĹJlnz|K&`^7NuLi|츦UAG16Άۖp?oo_$k-\t}lQ]p{NhhtzCÇ	Fx4gokA߇POq4I!'/kOKʠ'0;%c1SIiHfr5;՟h\C1=D=@H+cǲ|c[s8duќo~ѻSbBe\ޥD<O'2pkm['eMDSrpt}??1^a~e	h`u\T?M章=u[čN:I!{N}<sDl@lП%MWt)x]59+ܻN./<~eQ lnμAryYCcD<)C$Nw=mҎ۵&߃o1 ߇6yY3O'J?).y9f[`Gr[?".1rdΉi>Yn9v=snR'xYV{J9
;/ Ԭ=mw}.9s܂0D;YxQR,R'#mKs}.ieAײB'ywPcD:LSʹy?-U>0iX+K΄)0>l1ޚͽ:-_Jx`_?eAAy.ۚO9^<(?[J	}t]"z<'q-LZ2nALϦ$e[} Ӷxcd@tKn|{yy;#ĵA>O^"=~a;ʶ-!S:OF\b;@\BvrMޏx"(DK)11:ogk)Hw4d--@1~	NG
qfqpl8%c%Iܺ;m)Ϸ,Q]1'Ǻ)צ-c&9`<c3'n0nR.9CKC`1,7 NAN:ZOKXׯ`sh\,^`zwDɉTnsĲp%/͒piOav@ cJ[ԟ8/ڟ-_?$gRz7/y-sA)ĠaYbm<-%[T36)3կ`9YG;0EQ!aBB`1uX8߀yJ(cX
G"_Cu(r?]dlk{<'O"A&T~a"s6Pȉ)W^LopcP{%ȓO:\Vu6y f4nf䗰}<KL0O}u], |kdYԹ`ʗvt+K86Rg{v_ب*̞rކ_&AX?!<]kAs`}&T'W'V?kwA^Jy9K	zCYxJNale)\p#|X1'ew=RhsZZsPwrc?]rf6?͖~NP{Nd!'?|5ϹsbCUJu';ÚqbD]I$:Im;-'9KlkICq4R3h&uI/)ׯڍq%=9,>S}ؔ-\0Z/Vd8F+RX	-Kag;9oܟ]9ׯa:9iB(W}8M[8߁[Wrvh?:bȅ?͡b)6whK)ӎٜr	i@Lo݆)G?)K\b 1g%[:I#DX 
a+l6]uj39@r!!G7yx	Nr(߂y^)*6K(yJΪv̑@T:ON%0<)Qa$1M=U%`5m9f{;zE;<X;G7sW9pgP-)ܵ;GBFIщ	w5dR">ݒp4Έ{H"VN0{!4Y}Ѧj@0ri	so3W?}+(abq1{#O9+EXh5P w3XDJns$Y"+9rj'PSJpy$	l֣YuIn#YAR1sL$^
)I"ܞژ3߀MNe̷n1KHs<On LP!`Kj`aIy1!f`̧(gl-RLw̇!# G)֘J 
$QT>hp[k4TyrCH9.:Fԝ t!Q:Kb<Y4 8>H1
S;!nM՜ ̡9`28 ރNS'戡%<$ w8tq18ĩa3ݩKptN)enz> u" տ	7(8frOBLVopMLM|	j$5;	Acv%}*Xc
#.|l(&$98p802N\iE(p3sa♊AX)Yy`l`"1U)H甑l׆6NL#
w)bv243a"*}L1蜃 FO62sB3" `f`v;JDfmtB>}L!eRǨ_̝I;H޺]b`&à>giW4yta	ΩIG4`wlp戚 G>փG$`O`ʚ[wx!nDc
ʌnD=>J+屼](C\3'T?܉	Ry"b.{H>)Q`>e
mDD'pHǪ|ˌMxb&FN^&89@FpCYiF@#$la=j>1HT&p2;ɈjnGa25xƢllnTQܜrgS؈,IFrcuUG )`v7,:JN; R6 #FPh>`r@`w9lR[Bqy: "!܌L(<(
382dPp8#3Dp9D椄80B`%_/Z愠x
,Pk&aר!J0Sp!)בZ8L0f:%r$>إp]RMyɋS}kYr8pɯ9wYS1܆ɚs9"	 )x;gN!J*<p<\uƜc`MJ#|R2F;NɑEnP=eۜ!np8Ā!~',۪<gG@*u	օ	y?̹dس?$lv<1odےwMyTNn]e-GU_ϡHyp2/
צӺ9灼&Sc2ܴnߏ66fz}|cq1e9=9KY"1(5<ށ0m}x/oWIߟR'zx[}>A!JFpks?8m9\go)~6
LS=߶ٖ@
'voև!?װ0/pR^.Yn?r)0mEm?$^8ôuKֲ2ARfٟ	[$0;TNC%coiK(~3sr]a1mMSɧF%؇53/,-_8߿ v_MR֌>쐔_r
v.˅yKXL?inevǙn_뇔9Ce)Y^SO/Оwm\~ݏw
I~'=ۆS->Ơr}RL:a$;>0v(ˇ}ė|rd4hx^.ZSy%(J@,t>eus >0w\2Rlp2xU;ǲ@?9kׯd(sr#W8cW7SF%~=O\^>]Ņ6p\/Ϗv.|r<$lT\Q/1S5!ow]?Μcb(/ kdyŮϻWQNs7_^_~%.NMIּ<rͱ[c^NnRHX˶'ZboxrΉ٨RCu}F秳"p٧xOk"V?iH<?)n!Jz=%-x߮qs^0æKqB^<|μ~̫;M/dz*byݸC^su}^lr:a\G9r14nq]ae94FW*k8v`TcĺnX fFGuilXtyp5r0uUYv>\iV)P-.a9ޛsM೛%^~tԯ䪻rVa(s7)Itu݂{eY@,˺ <ۃC"S6۰m]3ޏ('!+8Y7K>߮%OKX_Um5$'ǜWђ	QvW<TP`D2ѐ5ܧO.k6y奄1{fIj^ǽӠ1CSCDSWpi;{³𘂰I&=c,$:ٯ(ƴ5=Ϲ(f:ENdZ9DyO$Sn`r~íhܵm{]rS6B\pk+RCnqYR޺dJ2YԆw%.~ۼir)T[y)I]ԟgwMq44S@॔t<kLk8:
؇f8wv+-zs`ܥ6_mȼ0mn6'	eS}NJ -Z;l~l)fX%ܺ÷Dq	,+5Wږ=-Jc>ǰȑA?Y3Cp""XV9.p\O(1L5}[(sBN`#Q`1`L[v7IB>s
 ­C%	) _1'`B\г;>|yCǳ}:]^>mkJCUq["TkqtlNZV=i]n-/Us_C@\nAy?y	\	Nsʶ]x}]2[ne֚^"!+MS/qY.v:R^W<mҤ^ސחMט`R1okGg, 85J"co3zkuIx1\h%8<bg\^>s5rµwJo^֏1`IIL䱤kx%+nCrm8AKJT1YR\4֋`7g{;G5}	`GQr!}x|-bm9KihL~*/hw^bW磟mZ	Byzl;Ґ5\Tn[:Lv콟1]7pS_By!%3l[$|̔mioif3qsI۲yc(IC'Jyn$p
nÌx[eW,!`$;Sf(!rAs0(4C|.K mRMQHkBv{F\gѵ%dĮ`˶B}7l9;ןplfII"T؜<X1-%%>*
9S	Ԛ#}EBW`s%hpI3Drq|(95FSΠcJ MLdCCZz'TxԚ[$֎֐$FbQuc@D	=&!uZT (J`94,+0a8V:hJ2}#QT%/躏aY5\Ab9FY!qY}٢s@9%/-&
.qa]$!<:;a	EhJCO,7lo><x&55x@8-K2?(p3UED4$ȋ8
/s>1,`ѣtv$2{]_.1Ʃ-9<Esp} #]	qRDrwqI(N=eI.@`:c4HLՍ v}rٲhxDY6[)mCI!.0wrac!ޒrjF!M~Kz=Kr1n4DKБT3ܡR(1XT"fF:4"1x'i'߁ta)6*E {'O$jfi5VBL$LujAG;&sT^a4aM!  uaRGh^ҚӜMsDT.]E\cg^>h0Ō@}g9'l#QB#U9B%Gm90qRrY=[2׿
s8\iq(z5Z 	f!%zgD\3Jb	5fӣ(g0ǔ<Dd)f(X:G""Ƙ=lb)-yEgW:̧x}4,`&wט)xpwXq#l32J'wni#LĢ19)	NumfO$'%te.)D'g"=B4rfBQ-0k#|OeJ{`0QLQ"T"|Ҥ8M<{/)ܞs@8@H`4omeJl01fJ;wJ$`UA^_QbjENnNhsx}G┍T
tdr$1QDdg@
w7 Ia!!q:9J\?'H4?'bLMJn 6\HEnژYI sP8*'N I8h*kюe$~;CyFR$I8y-J
6,X`6Ld> #8oA s,yG$6"ħ@5\I샃dM$"D1. SLꀐ3n63h06'*Tr)pO	T` YkePK]KLSة;pw30H96'H}NN\	3a!`ƾǙBN63p}h<9d	gN2h`SCf`ve5ғ(PhK1'@8^D6<"[*,j07!h04B(pcKNTOs	Fm!L#83pTR/t:/kGJA eAa4b)`d;X89 A,"XyIe["1TnF'X,7:t.J"{Y΋#3U XR>58Pfc
x	96}㐽܅(i'$iٽ:T33mH&!6xWmIHU 6/p'ssX'edf8ClLb?ωȂg?ݲ\'f0\둔gt!2U#
`@0TF
0ptF03	SkN/?}c6/k}{αcTTq\eMt^ q)ZAM4h#=D& 眽֜1x}<r[xܝp2fŠL@6a 8+SI@p&7W(4e,fp'rZ` nvdp7v1v3sey`&庿uLP8	Np( k;ߞ>~cuWRrsTFJNQ3Ϥ2f$sr99fT	X;uSw	>LdA#% AȪ/Wуw7.)`5%P4'-g?٢,-K(æa8.)ӗPfH:;O!qqY]t6"LBTNH\1R]c(nyzIяZqXbPzj'R -Kx$cBRaH)'j<ֲy#5g/A^e4 GWۜ:9GBpA⾼ej!G>a_CZ g0d1r, \2kxul۲L9;B^op(\qH}/v=cʾ P}wh{HcAN]R.?VSfLfRf~909\ha1$^L0Ǐ_m%O`z	IgCJ;H?Oͼ0<E<wvs<C|*o$K^}|:6[?W>]5E^Osqwig?cDTj17vv}m+lPgI9D_IxxZɷ[@'p/lxK:KN;~K?<uܷ/=gmo|C)()09JlAYal`u\|Qۺ1]/C	\
ӡ {뷄7 ש-Ȓ&,rz[siK;8͓_jx5p?YwH<^n5p}Ez7n'kX.q?^>}tSpǰUSp"kfץʗ;pxqް0m1+aF[8_1	}cW_|W[ílb#M!uT6v[I:SI¦)Ǐ_t|Sszz6>-|([ pLJV
1Ry[^W>?5dt͖WqTfeG8d_bnqN6Iak|:/*0ph3D(dTopXRe:~"Q?c[^c}Y ? 'Ҳ:sZt?nX|]믱?<ҭdPqK2ޏW;^p+)5P1:e-y%6Wդ}_1FsB>f]{x=/VP×w^˶%wTBgӶ@ugG{sn݇e-o:OqYxe6JFTopֱ}h+To0hnerE9^oٍRxY%wp6|c,fݷ8_eŒhï=~?^3 s8j
!%m^K8qc_a
F{?)fI0we{+޿?5_íMx>T;\"=
Z.|6%*kO,7H.4_RX28 /}S8m\)%qG/ipVpHQ&9M}O~x[8y|p9=uck9rbYoExن7%`zhhR%i$ALq2Y<1ܻ.4֕&6"e<mY&6kk>/]C^@NϠzuaT
?e[Z0֠IG-;ist&7ذFqo8l<OBme{?@w*D'#`<x[7~]jlBTҍ'ǰ2tC,/16=!=|܍70NT₡Ҽ|9S|c;Sb1TWC%\gXO[-D|FB_u^c]N}o%;L
5C`aĝ_ٖ(\ܻ)M˒3>!5
 ̤Tw xt/_܏O'm}%-^(xLީ
gjKnxTՋF)8,\Ys)+Ez\=6WהҖH'}YtkvY>ܯݩA0BĚu$DpFKh$9S#L>y_$'pY3oa։,GF9R0?R(vΗXٶOI=9{!9&6.5D?ۜf&؅Qo;=K?n>Z}:Zo?!˰,K<e)Gpho#ƯKhGX>BV's( ._niVh÷[8a_^$S&?ǲz[Ty1-{j8_#&l-GdNXOm`IGӰ8lOwlbg+]6¾=EGS5)f?޹RXm9'V9_x]c,V#&iIi9D!w:["SwVngk/(lD"9;|AyMu5%g<tP
"tq˾lvR̫+`!9 --X50uu	AWK4+΋B؃Ӹ5PaqBzۍ1ץr1Q	|98y>sMh!%^$}͞]5I͵}W)ן܆n'ڗ}v=]c~YB >#o?뼄Rc'eJ1\ DYrLWC,yǲُ,6f<Md)NC_ge勮=|IC,RL |$ŵxW;cC5N}/1=4I͐5bs˺>q%2ib)~?#eʽ]WRBA {c$\J90&,)գ\1&a;PdNLHlR7x1d[ct8f7/qs5)ĐÁEffTJz<bqa+y,u	$mSXyἥ:"e_CirwVχ#GYFT !ԟ
$k:yA5aB D#vVou{\AցS<nL{@dQ!pL%k_=qNnyrdm\f1><q4B_SCdȒU|Œ<~	7wjg¶qG)A{PNUKVe^08^}SP&r߂MD.<YXPr#A%ˌ"qLu|ꈔ<hQ$>z)%B	7S5 aniX9ϩX"\`HJ3i P
;T"lm'Ӕ.%YA.惕J`[4p)30U f"o})8Xɞ DTp(@>,)+M%I
֬9A7#( 4Bi9ꈔ)s*b́i6 xh}Df@
cT'K!hPHaદ%yG&gp-p,@g7٤ /,,s>3pWRB>]63B q]Mw1&s\R
1وon֣EVdb?GFBaSQ6. ũf%'b >2ZX"anL9ڜpMpla)GN擧ai\mQӌ$kgY!GP\/!c."&8uJ $f1j;9S#	p7dJg "&QsO$iY/~cF"R0}.i_m%&z!p7075a,9G+$݈@an1JJَ$'"-*ń85H	F0Bj>&	 T2U"TS#&o2hctQJ^0KƜQC>	!v80dd08|$Q9 Dx6Y bSqu:2.J6	#n/5[98/w7tָ4u\>HA%a:=
cj18@eIb`w7 Dnc9l/(p'ukdJ)Iv8;HeAE0(y&}6gF5^٩Ssf9,6) s R5gi2}T	@,	n̓..,hI,$BN^ك+^Rpw%gb6bllBMC$njYXfk/K]|8rGAT<iH)
Tg`P1@fn X'c''p3á{BLCU$LLȈ.e#'@pˤ堣](KBZ=#ЖSAd Fq<f,ZƼz'ٜSU)'IdigV128jt'F_ȉ̆Kj.\B0x׿73Hu1&@Tv`N`04Qʸa|ƩRDtG)ܩ`dDNPɃŁ3A(T8p@Dtiq"\r/Rɜ,T:\]M<	l)ȣerP86cH\\U	)F'w;'9 vW3  y8 c뵶lp;@0YH	DJJ;p7r3BnfJ&.W5@m:,(462w&w F3`\`blǖFrurà"IMfJ H#!ۑՍw8%#4
 b`NN\νUo/b4!=#CEs0xDue#~9Y\cВ
i!E`<ƐfA)pq@p")xp=Ҋbd	$LT'7qLu͛]?CLJ\Ns6y1p\/0JZShM,o½N>-dR	݈uk=_ɭ@?>_c]VIoָO~e	apCq)¡])=8ߏEYl\>K7Yΐ(ɔk8M>,}Ig?e+4"ߖBzFňwpۍ,bN;8ټSyKwƣ?_RK2u[7mߖO%a-0BH9ˎIr
TXs	ldu)8_)g5Sʑɩ~'C-G:_VhO}@ߖ}|u;W ݸ?v>?9o<i
f{prnƥ$=DI&%7roǁc0Pl^xblWm_|v/̨֘xkKs/4cJWG6f3
fs<)?i5H7pk6$s|X7a-|3Ȳ }(2~!gM7p[	ԟ'\dEǙo?|TH/-3|RLo%G-S78y7#_ݓV*T9}|] ;lN7vۼV:㚙:MҸH{PaΏzzLQxpuco˖t_G%>dx¾HPCx~	y
9ꯅ[zi70;ymx%du1}z^1}.>T'+,H!j]KSlrc-l!ܼ)dB0k$0/~8B׈?T؉6RYmj?_EKbS)T;|]f+gRkSZoc˙ͩ1|rxlTStk1>%YE0h\<E5u3`@'Pi߅8`HPT//|K.w	I84FNR1܆z1>1	n뚊5uR~΀2%(ka=R|/	)$V?iHy+g7O t\GpF([u:߃kw-9jw^)@ΓmA8^,Y?^Q>fjdq?Ttq=-ےMsAOLE*98bD\Ջ]bǡIJ$60,K;yMiJ/,%%yl!'f<˺ݒ`^z$\g#KR\egl#_ed_]Hx,!Dq:<%acYn9n;5m+vŠ@H1޶ L[ZK<3q(nT[Yd'6	Nsy帮%ǌQBL'PkFTrcx!`1qQY8s1L5:˶r_sH?[h	gDRv6le4~ؒ7},H<B:1"!8?@R@t#t^$h<e-Օ'hl\z%s9t	aM4G.mY<Fpxz-~Ra㚂^yub:a%Tp/fW>|hOU7M?ӐC%^Vo42ܯu[w^>i[%nۺ)
+ʗ8Rxۊ|NŶCRd2¡m"o=wӺVd^=E78O^7`Mzs/aP T><E6[
kn!L~-:Vr\p+1'@xw-yF[ "LOXZZ{|3-o{!4+k&;|Γòdc$	oyy_>bzM $K)ly1w>gb9rdz6 ˚SQw5%ɹsКcrهuqX*F0hݒ]9ev' ВVnIb-xC^4˲:'ێhRopI}~5Ր֍5~D6kW{\1ؖF\L990P1JauvmҰW37Q(5)aícY׀֯6HQ)*A{$2lƼ$jbg:yJqu~uG0W@*E<G˾L?aƫ9zL TZP24!!mt22`LoL"dGTN#.f~ك&rC=Hp;up7!Q_U;+vBT!njm!:'E9lp9?g ?l`\"p0!<.⴦|f@\,+s~(Kact(dBKy"N*DJ]Fe%S"spbp W7<J2ю.ݵL9tA0]E6w3Q@8ۅ#ڙc`kH`nu*$c 11! 69Bqz!X1!3 CͅY1	Ұ&%_v!&pOn*w-4]Xr*C9+j@+l>](OѼL>ڣ#%	4o]	>disDav%՟d6(_(Ρb#DX`vdEF?P.C2bgEC@om
/Q}8eI)H 7G[1uysA8T8PSwA(c^(uo7o͜gSf/QF(r26D7F]r!㖶#mBجS1GoSڂv\K	/1fa &?4H̎Si]v56D>N 
Yw@0T#pBKcLI#2@T 1=2RFbw1	9Si嘯"s,  b1qa)qWt$YIa0@/0't"H Р)1j0"rԜQUF1ȗУ	_P)54șkv`5P 6i`ç5XtVF#8LF"@d S8=ӕ,]$hrc\-c[S{A'E3)Ý w O)y0S)@FN:+p7iA&u b`zQ6ɡjS|qP#d|+'/ݛF(?\`A(W-4#W`p9w-^r68{DAA6g*.FgDJeˠk 9)Ýsw&66s7r⹌ВbY4tf4OS3(=ZnI}yݏ2CJg8Ȕ=\f4Kg>˵u,}?tɩ~wPwqRgJ Bb9K{wY2h\w\cHTa,BASE      \  xA 0:-MަncPHT
J*AbJp%Ҍr1j`pl0W"j9)6WHr)DjH")HX*Kd)k)PB)KRH$̹a\M([
8	%)u!*NKT-ۖ4*J0mX%1(Bڐ*mUdsj&[ȶprdn$%*q*ihjUөRXX
X*dmCiZ-&SRI*ж45S$Y2R+M)-`Α̌9siLjZm-IbP+5E-iܶRҪU-U,*X(m'je'\r)[mJUjw'Զ"t{jBPOS      b  xѭX[E DYsڢt?լ߽?>w3}qw{%_{f]U?癭N~nKxC6fnzY!lmi<w`[5*٦2f%K3X iV$&&3@XAӢa^V)v2D&aYcB؈iMh,#cB`Z0[@ifi֋4az ӴfPzyǖ6h,52m0X+-@3ִ6@hack5z'iZ-:kQиQӴi+'viy#"ZnNvnSݺwnqvv4}o?N_sS?gs}?1ivϿOt{BACNF4        xnVEM>]"E H:;E##yV#\ncٷ;i?^wFu5@@T W'٣,JdP+2`PB Y΂SfO \Cc9J1NȞ Ȁ 0,S	΂ +#re(op( pȀrA`dA`@9`FVAc倳GyA\c #g +7O-F`@eAb+Cb=V#/0 Ǖddae(,Fp%j>{\1@GDeAep4f@%d5W*5d>0@A|^NBu	j,agͫ{ǑXQg>O}y{6vSvt:}w<\ƇvRy<ڏmQFe<7b3=.,{u<DzyYe͊eеklclܺ]U2:GN
KZV%F6ld#F6ld#?kTEXT          xMn0(s <3$,+BIe.a
ca޻	狤ċ$].+>)%4`gІ=bIr:_ZjV'u'|}R1+lYrê{JIe;١PXu~0[sSv\s;@ZMK\j
d	7CLIP       	           S)     S ZTR

SMP4      L.  x;ۖ䷵~nc̹־ouj%0>"pe ,YB-@ @$$$$='#B,t֜c|{k/#L9e?|?k~~jY<k??G?}OG{za_5T7RE$`k6$e!#X</Wa/@ {)(_>/( !W8̠8%FS"utkM:ϢfO{HS~a,c>#!N&9ej)&Vt-sBP0Loj}43}<ۖuo-0i(H]<9=dw9o,-0%%95RPhM%;S kx!k<%X\78sQ튲Qsɑ(w08%eU!1Fپ?} Rp\vax27O&7.<mo>.R8Z]Ϡ(h<-њ%SX_oym(?'F˽X?ƅM6!σ~)eLX=M|{X@+8.eڦl?Da9(>qkI߀Zo5qAn%%}.r6O|='EBoXCCY\aY^0~ugo!]!ޒX{4P/@I><+mat߂]:vϟUMZc9EuBY?~X2o~F]MjTGc`'?Om{xKDF ec/?t:::}YoI`e..W; Įx<}yuJmxҦC&η=o۪Կ

nhB:Ooexy~}M{;9m%x>,Mc	Q)w@!!^'P/7_XE.(9-!s}g7Mp	w6mEףM@]56yQjq$JS DH"{len^|NJn'Y[8+,xA{w<}S'	.[лIwGZ!:o?;$!Yw.)lSX
~emRgLw]9~,ϟNúw|uڒ1vH!z58i8ze<JZWP8ƳK'\O#=e!hkЛˢ֞C4s.Xv~[(P벥qu}>0
̥|q|*EwqI!R1)sD	[P\e]7?bu<WsS85D|]/9F죛ĸN:)G
_ ){rݶ	:{D4ۀOK\ܦ	Z>8.n۽?xSY:%fze/*cŭ-	8.2݁x
8vg@wB>BmicThm0{{Is֟RNee% Joa)lE AGNej? 9>x ?Kjh֙;rY8/_g9/s	Ɛ瘺}
J`{eNY۹Ny^jӢEn!)W_*Zt;LXtDյEw s^,7hD3]]^ސJ
uqk~?~Zy{1Hy2D;γ5,%	wp^*i^S8tE@X3i:Ϸ5꨿^Sr?dux/jDzK0DzY\ aW?ǃ//_D{  Sdn(߼NW~-,ٽ|\WOOi0C~sޯX5-u
 @>
ϻ2'JM|Ȳoμ쁰dX{'KrnZpߖlc/|KP 2/7Ceg*)-G8Z>ܛ ybڏ|.Q 7@~)K^,s`R(ρ8w|+3cRnB8}*1Z-ϋ1D~;~~GX\Y&ʴ-+vT @6^o#(E|\Ӵ*@߁fMLޞo,A\ g\VOS/h}jrEsTcL:O-MAIOM3d2&$F:<-Mg`db8JHCSΰ_<	TRV~Wct"-Z?PJ߀ph9l!8LF?G!BU }\A58G=+cKJng@NC/:om!'g.9zM2rߠFZ?be~Ic"+9J1(ɥ~'Dutk҂RƙkRm8żK r% :]ڣSK&=Hh4I2EV)ٵtDBńΑ;qmKN Hp=br
_t5z#4{!̒ᆄ@qZaqу:-E$HpȒ/#"0H`; h16Lԥ4qGO1dQEB%	+(xM0Я%ӺIVɃ`p-cbo) y]($ XcL#h#>LDXPrQGsה] 'An*\f2:~FDH߀ HҹeSD_$Qꯁ	-DYJL19BFQt!KFQ9vK죟JQa)!R*(fhG9$qK@)q"n)!\+ Z.)WuD˘f;__)k~haTw$]!YOA
A=	T +Sf@Bs  Aqaa3
Gw(qJFQB6.99
 tapmcm#f8]Hm5c&H	$>%J:©BɡuvD[<]]!K)Ғ\G;%nn		Jh_Gb<YʚB;>%m,OqIP#!zK
8@@`.puO%	]!Q[6HB(vhIiba9鼆؆9PF䤨{"y6gmj4?7믃 !
	ZR{k&B8@PH81]uozq@!.p!@Iq.BF;.帍pfHK[}HQ3
 D BwFx06EB @B!i'E9|뷠5!t8
ASMF x  A($ @).p1
$WPb BBxM8@!\BBq!A!1R 
]\B(Y. PBABR @@\.SW.	R8kA$ŅqjpqPL\\5bb8š'($q@AB
)p!`M8	Bq!	"IC]Rk @@\HxfP\f)pq
!t58I8pp!   
	pA!@...t55BH & @HSx7AC !.	H}|pig08%a''.ckIsi0N×ESp7D!=	,ү()&+=PvVb)I?Fw럄ͮh9~jDtgFs1tT gKLI`HɆ+Drv'[`f]}42iP1&oay.y=z]Brx]\1)+ѡӄCw@p~\jqAYԥ?J
=@Y_䵷&
uкE1Q(])wvc)Z&=.8.ihsO-y`0Nqv\OǬ% `%႘ Anp'u~192 r+Sc	5"וyP__/_d~41ys2o,iA
ic4ٰ1R
Z4;Fv@aקL0mU	F	KVkqJȨ/؞a˒!mșJ%9tps{Phd_$W[ST;,3lOep8[r⼬gc.x>B1y%,zngI1 'tH.,~v9P e펰Ow-_5>cįn<>-'P1&<勒h?k֨{W~Yr4Fߟ1χ?:<_8ܶyR
ll1_@bАq{(J/S>[[0c86),]y]9;v#qm&	($޶yrq<^Rh./ӼΩLPJv&CØ_nv}~M5޻meb2ͯM~||qq@z}H.APhAn۰s4#ԟ0n{{uz+!_·~_޶Ǐw_~4?zOtWoDxz~~_gWSR,Ӵ$L1޳o~aa]lY	v[:sӥ4ֿzwrۼ]0<![BNeY_.e~{)OL۲@D*ˇ};Fn_h|8|cO/ox˲~{LKIֺE@v{iٽdamNO׷xߏ-뗦ӓqt?lYyrNȑ$Yhi_omEǣ/^&1-=Ao7|"%C[v<#OˇlG/:Mq /ӎxp*qlwGjBc׺Qte~]Jp?ٶ{C\S/=K(P=O>q)@PITn7`y(`mN7y<]c˭f-e" tZu={*
Py1<PťEǓ[%&A>C<P, 
1<׉R!|䴮1n}BۋXWSʮ@"Ϗe-z"a.~'g9:+G:O;ί	ẅ́o@s^sگけ5io`YRwLvSr}|]?g\|Ty[0zvjӺ=KRޯ}~y<v"}G?Cx>yG>霷pX<HnmA,P{~ze8GVIt?PIK1Ôs!U<f)EiareU/[H.R789z3-mMep㼒e)*ui[GQ,z]'.-`<cQ:}6:8{:hAhPma~>WJ%%ueݦ$㸮3/}fy_48Oi33JKkRWP|\}*9l4oS"T
+ʍy>)ԺDOG9B<E^"L~CQ?ڸ$T6~uTFSAo"a\.XHAʔ%v>Gu^U՞Cz/+{h7dJnXkQ^ʤ39FqsP{#$C3 \ KَǏ^ߒs?6-
JR.nW/|4yY,:uc?G3dVe_}?.>|ӞAr
C߂I&qĀl9Lpw	/h)E7A6I?1D]so~9)K5{hydermC.OzROH1Sא;.ݧmy?Lǳ!)6q˷%ƫS0S4?:Gs|:	@]eY:"L !]e]ۏm?^-s?3]]FporIC|<k fJY,lEא	wpgR6:^y  !z-ާIIhc[g%;KT!:m`ooAeuiφPD%G~җmd{߲fNtrck"Z+_&}<TBpzG,icBb*zCY-ɎBz,Eٚ&	80%/.@Fp^<-ĉxG
p눜S<%de59%AA-ԯAwPۦ~mNE~^Cd!X+$a>9<o%fKtyi˜߂ZRP-ny^KhgKAD7 )fZs):lg?Zd]CBGV)l5o0M\>HUeKE"RAk#rD=ۅɗ ycHM:'i("lem;U=H- -8Oc<m΀H9ltƴշTjG8 ˶~0߄Y%kzu1߁íCsʬw5/E5@j;ޑRL%ī0!/wA	K
j1lZ8H:msN~	%HpB)ij\tb	nrUh
_Y/@bT0 :O-Z6L_cs}!Qh@'zNNIIΚ$(CszR>gh 1orʡsgĽ 6ƅ)<gXC+EE7pY"K|K(zi7ρAԥC$Qd*i@N a$Hn[,Dz$ҏ !2CD?ÝCD
hDPBݏS-5cH1|aȲI$	*{04>˲Bu6ByV݃B\% / ͨc,YЮEAYy$ t\sj8i9,e4%u\RwiqB6"قiYE&edahH =i,"7CQAu߃pJNSqeV<'U{pn@A@hηyJ-@	SSQXۤ˜Kt뗚M`,EHMBɑ>LF*:p	bJrJР @Il1.v4ݯԐQ}\SNd;,$!@:@޴RDP1IY}W2Z$!fJ&JT59$Hwg!L<B^fg)&Nq%	1`1qfmYg̤CA0DonL8HԿp#%Ĕ'[RcկpI
et[.[sjm[bfWy7%>hpk=JPq~[8Gy#@"ka_L
ޯ$̃K*t[h]%sY`W2[J]0!7AEva4IlSJ1#lRr$3O-8z>aA|^G*Ӻ_sLº눞W{2Bk,3h5Bap.9`60%	0\aDz@kdLm=x]܂hJwq ROݡƕd 虈z.F@]S$:/ Bѐr7ؚd`9q X
{
JqaAt@Q@ridQkn˹^۹N5N@cb˕xcP	!XH"NqJ@gxi58\H ?BFB 
T؎mm_u̝Q@BSA
\IPG`:i,4V\\]@ ?I(`‘8($ CBRH@ ))$Huq58(.jk8!t@8Eb5B(cr8 !$tL$ !BH q  (&.!J 2&8 .BbtҔ
wB=tӘ[!\(IsjpqPH )&&&Ak@vq&FB.pqquq
Xk!.$..^3pqqS\Dq1v :k!P\?C\\.q@B@)$pCL(d`+`M8(&!!Q@I)..p ąc2PHIq@H!A15AH 	B3$ t!)C\\ )pI$\uAF*u+t!RL|UDNP%	S΅r@Q4[430AjJGl"yu8馥5!TH :5D4[H!#=[ru+tK
ehP|tkeLq	y1FÄDͺ̌.QUGR;w*f-D}x9 xnc˺rNJT%BvU	b;,E6Z}D!G&⏠GLw_Zs1~<OP1:)qbF hSzݵNۜu]m"F|ޏGC&8Ф"vꪌ9[l?X}{GZEZ1e^j_93_qzJ@#҇eՕ᧍^Š?͑ey~bۇZgS]0vV}`]zaq\TB+|bm>xi,&|P:jyʊCd
^'SN#շې,e L)#RG˚BOy4a<|q)ۏA6BZ(},H^v&"g{ԔnGk:\i1|xq|2fS:mX>ϊ=Gu?ζ%Sriʲ?HoeҀ"A?ss,߼}Gk:I]z~6^>ǣ9ʭJSr5Py/kOAw2o=H%rA_/cqTTzݏ%G;ebęFˇ4yu\x?/,H?k}{y~<zt=ٱlL.i^口<d>|.x=|'g6乿yl2S+8Nt{[O7ax8ӇRD|1'%˚ޣ&<<p:|bx؈cG[	v kk@׷oz<_5}*e&GIOS׽."p
dȺ\5۴NJ'z<fY!ۏ~hkN6ч5}.j7}7eIO=,
n FLP>ޗSp;׷&{D@VE]q.|\ݏ~)K@t-)1WުqFs2ߟ= 8Eis7W_cƖ{|꒫)uCOTo
yudyMi?OL~v*
n8uu]rPcˠ[=p[]_N~pM/yut<q) u6'>-~<Nꢄlk]&>%)&uʐ|gY?)3t\o@aֈXM[gJGc&ټ=;-On$"u{iԓ=qf:[*buMco_ZK>(!6<ucszˉ!ґeyܹ
+uUmxo׉0%l;X72͗u{:˹?EvgX\"v:"O>o~,Sc1qfOZ4vEWd~\>z!c>7}WM]AOKyc?,Ʉ6($$g@?NWz9WW*Yk}G?|@;6j	9z|zR}<iWRPn?E,/dԐVM=ٚ)%WrΫ1(Sl?Dr/1i~JTa<-Һ^Qr|ρe/}غ^vRoduSr$m7;ݖuZUyzLG~I5bgVp2g
Fr[}K4'n?4u8rpӵϬ2dB겈{?OT%m߁q$y]kl?
9ۓ2TH~uhq|Zkt<byD?Ax/-6*L=J2)U(C(:/9Fr~\
i]%؞TFb-hZ5y?4C"kȭ}9y*9 9t
~6y^Vc$35|Jji0:{>kբ"	!O@x1eqY !^R[O7Z`_{ sr[k~G4C(Kqˏ>߿ |[plV!(S|\y߿2OF6^x,6Kg?_~Sn߁JR,=N1NǺ|`PP@}Xh{`]Aq?ҥ|<][\|#8rGtNfHl?ޥ̗)ίwìvyq~yϪfAj#]ez} ՚\Z:ؐGĘOM	I)+"^׷?chVo#ix)ޟcD05]RqW!ԷlC辛%Wv:!tVV1.ap?J%ؚyl#ۤg%QeHt0ɴ̐4A&Yy[*:RfMH,xr ~:s]MߟiRTnDlzCʉ퇈|i7@-"'1xOk)!cXZ\ղ[izzjղPe[>4M8z\Qe]0Mu^)Ǚ\~d	iN?:YOQ8.I8B!~jc'dRq6Rt>NIX.in>$:O͆$GٰLbI5k-l}û$RyfL:#뇔K˙&5R-RqLVkMh2Z0 ûO'a9_n>
ödw`bk<]'cMP6hEJcf$"7;sz{3{+ya肹\Jf2*w@fԤ=f(S)ys,Vjn!yIΗ\:Z(eb˵n-Z^\k*bg4'D@FSTd?yFAzI:TN۫ZJGj)]F$qPXgZ&M1*TDҒ
E "k\Ŗ)g~"XFSPl? =5G$g1Ζbs)H>$-lk1P3D8<ST?>IRm\|(GDI ̦	3GƢٗ
c*;u3}GI#-#hi2hU_!TKF0tNyJ}V,[0L,Iw0K#TO,,NgɠAj)w$$HbTJ!p[%Batj	q1 	
ȑ`g
dP@-kEDξ2MLDjR2)DDBF7,0fYCC,3)Z*U:"HԬ9~	!HaR!}/ I@[zHp4dZsκNJ9i4S21b&PВkQ@Pgv@D1(r*	 HH)H !.:<Dr4AA*q
g"d) МCe:$HQiJH'Dl	ȑU>YbrڬW><gx<F$۟ fS&kQԴG~! !(صq"OV]N5Wh [1u0U-[4M&(Y}HHKLxQ]
zw1A$$M]癓yAn;H %!*B231=p_䇗8Or\DxP~t r-_//XdZx ~aTAs~r Y|g=/8bK !"w#ga9WoXPhr:݅P@ "'ÓzCD/]-Y|EȪß:zz>(BP}OA B94i1ΙYdq^53L ?5)i
u?pB};e1GtiG/**AE4$A@ 
!!FH B\HBdL2j DC>E:u_tN'@!Dh@B.
(u H%P CB %DHB
 AHHH!.ȘBN
!8\\r$ q	!t	B l	Ah[>h !$%	A@\ 4BA )%h $% % B $$ J%J D  I	H		 a[!)@A ! 
	
A @P@$@	ĶR@
	!%tLN04&(Aq	PHHl	E! AupB\B Hu!"!E
) @h R  cT@ 	@bs % %   !!(aCBJPb+ H0!!)2!!	  (*%B[!AE( !) 	! n!DHo	Bn(!
B !@uJ $خĖ@!)AWj B($ !!?; ! #$	>'m<U
lc<nLZTc0>tJGDEb
;$N9ZR@hN'`UMBD,9kT1l?S+vɉ=GϷHzg{l2#p@M~r%lPo?Ui~cM羿ZHCbj~.i*4?S۹7N*4vwe+8Be]%10~]F;f??a۷qFu0a,mwz}R۟u(:bzM8Σ.Zz헠}0-ooetخB\n&8%DQDŽ?Ȓ,FyY}?\<l\cE<G0iKFшU(	J0Ja*Jنm7D)x^緔ܶ7g-o+(Z\AZ(Oyl(==9zdퟀ˼|o_%]m5(9_.g.3D[.kld.:/I&=<~}ҧ^v6ڥNF0nsM}"->y޿ܿ}ُGյ&Pakg].5($d>ǥ3{zRPz;mse1bbя:O;i^F|Yv+Ikj~2zOԉwA8|^o.j5)tho5Ǳ:WIBHl(Þa
g<M) ! u:-s@_M?2-uy$vf$жt0|C!OA6^?֞#Y-SP? UMRw<S*%L#bz}z?ZEpR\b?1"AU</%].Ct]l?߿Jz[>eR>R/wՎq4Ɛ;xAb~{/KC_ z0ze;%]m^}ٮ`z,c<rMBrx{%Q\;#:3uM7器,V~kV#F:}YvY3M8cMm@K9͹ψ.u.r_LR- )Y)C_bsҰ2־?eYy<]-K|'+ij^㴬5ic?^jU{qR:i,3Jz#<?ϰXR#x?b}[ͳMiGwQuIiUvȗrUa^CV-@7ץ[OLC~zӉ=yLIBjs~zȲ\*q
!_!Gu:GeI>ve"aۏqB6GSݶ FSTrAdlDxu	jZJ2)ޟTfQRILVǡyJ|\kV~SeJg,Y{2/q&*K0AiG)%['3}r	<Q&Ijk^${?:(|tg?f0~
Gw߬/e	%(7>t}J/~|GZ܍;t_GJSz3Jw妉qzyM^ov<׺HBH//وy?X9`)rˈxOy"w`rz>|e!.۟rWU;Qlpģ|[K@[sSZp#:I\e޾~U!N[9cym@
r<7S?!_mJ_~ՏW?|py멗l "D|y3}0eolN3 B?O変]Ati-soA`؋i]qcGHYפ~e1HR=^DM Į֔m^ײ>J>{%ߠx׀LG#EʰAD֋-g? IS)?1^뭖_s4
?,%yv%P ;eys2j"]#N\K6Ld-KJ`=Yj!1M1%uޣtjqVd!yI!%rqty(<t"Z}̷l.qYfѐ[1ƮI&۝^"l/F^)e[A82s<usԜ2޺\+!,Ysl/9б\}_Ô8^ [d/8]SSlqjb-c<׷8YlH$76Wuܧ4_ryu.b?qKZ̩ѶFDC2M;TFȰ/h1%-2;TM]?#OD|bPp)גvȒ!ɲq\\?DȨt4D8]tmC]rβ F	+lillm)1 ܛ6Og
&0":R_niLmԪk*ލYlh EAަbơ6ed1ߪbsVɜ/r"sB{dMuq쀱*`t)#*zL6W:M%'l)im*_dhWc)CBӤ0
ǈhLeA p8eLZ5KPw@2ڒ%Sb,Ej #&#ƈ
:Zj%EcoQm9HH)IC22DE@LFSB%%p3DE?18e<Ir!lERr=X,b*-@$2:#PSHqq!śuTNOjs^C]5dxW4Knli1S@K\69DeD4Xr6k~'2AEEǖ(0aKXʬ~Bˀt- ^n,A!H:-{Lq)+"o!,%gyX"IN)BrJ# 9L0'~exCR]}$+&I]@4SlݣfT4 0\Gy11[K&S+!` ]b~pYy/ RT_Ή
b~@c4uɥc?9t-YӤ`K)cwHI* CPk*lXK<6$s@"@0Z%YDhe\<bJnQ1,>'kKL}灑Z$d[R-b^jd*B UȒHiPt
V+s턊(}RdڎiΗx3g@Z/Rc)9ׂhZ[)tBSUK Ӟ/B>*!d%@J=)o 	0^NܻdӨ^BF!D4B@ݻ$hbcXZ#ؔja.,Qxzܪ[q*D@DZ)
Td#j!j`/a OA'rhJezp*S-^fHPBxt՚晥q~Y	&h$W-G˚1-YSmI#W5H&Rt'`IXV@D%YBV^F"@0,UUa ӳr.c]M+3g[/%rXbt֔Sr9Hpg%RhrhKDZ
fBTS4{ "ʈ-CI)Hm>@$gOT0I 2G?![%$6 A!	K@BBH( 8q	qmS[n
[0 RB DH5 $(7A 	!A B   )@P< $Hks	 !% J "$$([(A		
kBH
IJHP n	   !.!@@
IjP B!GR@A% R\"PB$  B K	A! %PBBTHaCH
] 0	J   0%A kBH		!n[! @	  6BB"@@Hu[p	-($ % !$@@! TJRG !Dh  
	J0D	[	!  Q xBASE      +  xA 0:;<0-M^w.s!"d49WBYdT!]e.@¡)lh5SuJ*r 2	6 LYTY0,!@+F1Sg\EbtS6,&fl4#r۶,\dA-mXd	dbAt9lR3"ӱͭQEcb́JAd͌E+k͹l$EI)%Uʌ0R(RMŵtʢ%RYe,R2ɬTPjB4&`nAN2af89H.&#f	YV	tӄ02`۶涕,`e4c]PUSUUnnNm۶S-QnUZUn۶;PUTmp  ;oBPOS      1  xu%E Ea]O@DlHБ?~~ٟߝL|im{vy}0Nwc{8v_Swwqmsmm/vvo&򞻤UxOvKFƚp2V@BSVA˴&ŝ4,	Y0\33	4#f1V2ְPBBAKlCɚk hebZdpM E2p5v  dAkp5wi,hrieRn3).sǝ]*N=w-:vע,ֹvX\/w6u]Zq3m3͑ΫO?<*O|w|tyv|9z}=?k?|sh?-CNF4        xan#Ew\Svqa	f܄3	*d]n<3Q}aWaem߇~2|=TB:?⤛9Wqp(d(cģ0'dx91aJ`pty!a~. 1#tH<cϗOЊbD-"ca/,F
"0@1bQX<!LQg8 ҍ1a1@T0aJ*-5&;(,e0XS,ń qa0*'-$Xʀ<=
&dU (T%>ٖZC׼pt>Ŗsř`UN{/qs+-=[m(u#z:H>~lR]o:ar`ci#ϻ}Ѽΰ]~㲁۶<|6?uo]t6ZK˺v3r+w} >V`3iw7wۡgg;JEm\i/uTYi>#}]7D':щNtD':щNtQpTEXT          xKn0л`>c;Ab`J :BIaOKRj6nZrkYjԂDtiX^w C*WVV)OY^w C+*zQwP`\(UZj0.У#ꢳ8qmϙԾana炞rНࢳht±1\D8C\86BS-7CLIP       	           <AlignableSequences trimStringency="Medium"><Sequence name="25_01_8-cdnarev-260121-05-02" ID="0" isTrace="1" sortOrder="0" trimmedRange="0..1242"/><Sequence name="25_01_8-NW1540-260121-05-01" ID="1" isTrace="1" sortOrder="1" trimmedRange="16..1182"/></AlignableSequences>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  %<?xml version="1.0"?><Features nextValidID="19"><Feature recentID="0" name="TMEM55B NM_001100814.3" directionality="1" translationMW="30185.54" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="1929-2783" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="18" name="HygR" directionality="1" translationMW="37901.58" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" hitsStopCodon="1"><Segment range="3459-4481" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to hygromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;hygromycin B phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="17" name="HaloTag®" directionality="1" translationMW="33609.62" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2783" maxFusedRunOn="2783"><Segment range="1008-1898" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;modified&amp;nbsp;bacterial dehalogenase that forms covalent bonds with&amp;nbsp;chloroalkane derivatives&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="16" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6733" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5942-6733" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6734-6802" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;β-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="15" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="5183-5771" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2896-3120" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4611-4732" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="6803-6907" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="FRT" directionality="1" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3404-3451" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;FLP recombinase from the &lt;i&gt;Saccharomyces cerevisiae&lt;/i&gt; 2μ plasmid&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;FLP-mediated recombination occurs in the 8-bp core sequence TCTAGAAA (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot;&gt;Turan and Bode, 2011&lt;/a&gt;).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment name="-10" range="4829-4835" color="#ffffff" type="standard"/><Segment range="4836-4853" color="#ffffff" type="standard"/><Segment name="-35" range="4854-4859" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HA" directionality="1" translationMW="1102.17" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2852" maxFusedRunOn="2852" detectionMode="exactProteinMatch"><Segment range="2823-2849" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="6" name="HRV 3C site" directionality="1" translationMW="902.06" type="CDS" allowSegmentOverlaps="0" cleavageArrows="1916" consecutiveTranslationNumbering="1" maxRunOn="2783" maxFusedRunOn="2783" detectionMode="exactProteinMatch"><Segment range="1899-1922" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;recognition and cleavage site for human rhinovirus 3C and PreScission proteases&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="5" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4874-4895" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="820-838" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="841-859" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4781-4797" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4805-4821" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-β-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
  w<?xml version="1.0"?><Primers nextValidID="6"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="Primer 1" sequence="ctgaccttcatacaggcccaataaagggatccaggcccctggaacagaac" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2021-01-21T09:37:12Z"><BindingSite location="1904-1927" boundStrand="1" annealedBases="ggatccaggcccctggaacagaac" meltingTemperature="66"><Component bases="ctgaccttcatacaggcccaataaag"/><Component hybridizedRange="1904-1927" bases="ggatccaggcccctggaacagaac"/></BindingSite><BindingSite simplified="1" location="1904-1927" boundStrand="1" annealedBases="ggatccaggcccctggaacagaac" meltingTemperature="66"><Component bases="ctgaccttcatacaggcccaataaag"/><Component hybridizedRange="1904-1927" bases="ggatccaggcccctggaacagaac"/></BindingSite></Primer><Primer recentID="1" name="Primer 2" sequence="ccaccctgtccagaacttctcctgattcgaagaattcgctagcctcgag" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2021-01-21T09:37:23Z"><BindingSite location="2758-2806" boundStrand="0" annealedBases="ccaccctgtccagaacttctcctgattcgaagaattcgctagcctcgag" meltingTemperature="72"><Component hybridizedRange="2758-2806" bases="ccaccctgtccagaacttctcctgattcgaagaattcgctagcctcgag"/></BindingSite><BindingSite simplified="1" location="2758-2806" boundStrand="0" annealedBases="ccaccctgtccagaacttctcctgattcgaagaattcgctagcctcgag" meltingTemperature="72"><Component hybridizedRange="2758-2806" bases="ccaccctgtccagaacttctcctgattcgaagaattcgctagcctcgag"/></BindingSite></Primer><Primer recentID="2" name="Primer 1a" sequence="gaggatccatggcggcagatggagagc" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2021-01-11T10:42:22Z"><BindingSite location="1922-1946" boundStrand="0" annealedBases="ggatccatggcggcagatggagagc" meltingTemperature="67"><Component bases="ga"/><Component hybridizedRange="1922-1946" bases="ggatccatggcggcagatggagagc"/></BindingSite><BindingSite simplified="1" location="1922-1946" boundStrand="0" annealedBases="ggatccatggcggcagatggagagc" meltingTemperature="67"><Component bases="ga"/><Component hybridizedRange="1922-1946" bases="ggatccatggcggcagatggagagc"/></BindingSite></Primer><Primer recentID="3" name="Primer 2a" sequence="gaggatccgccaccatggcggcagatggagagc" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2021-01-11T10:42:38Z"><BindingSite location="1926-1946" boundStrand="0" annealedBases="ccatggcggcagatggagagc" meltingTemperature="65"><Component bases="gaggatccgcca"/><Component hybridizedRange="1926-1946" bases="ccatggcggcagatggagagc"/></BindingSite><BindingSite simplified="1" location="1926-1946" boundStrand="0" annealedBases="ccatggcggcagatggagagc" meltingTemperature="65"><Component bases="gaggatccgcca"/><Component hybridizedRange="1926-1946" bases="ccatggcggcagatggagagc"/></BindingSite></Primer><Primer recentID="4" name="Primer 3a" sequence="gtgcggccgctcaggagaagttctggacagggtg" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2021-01-11T10:43:05Z"><BindingSite location="2759-2820" boundStrand="1" annealedBases="gcggccgctcaggagaagttctggacagggtg" meltingTemperature="62"><Component bases="gt"/><Component hybridizedRange="2813-2820" bases="gcggccgc"/><Component hybridizedRange="2759-2782" bases="tcaggagaagttctggacagggtg"/></BindingSite><BindingSite simplified="1" location="2759-2782" boundStrand="1" annealedBases="tcaggagaagttctggacagggtg" meltingTemperature="62"><Component bases="gtgcggccgc"/><Component hybridizedRange="2759-2782" bases="tcaggagaagttctggacagggtg"/></BindingSite></Primer><Primer recentID="5" name="Primer 4a" sequence="gtgcggccgctcaGGCGTAATCTGGCACATCGTATGGGTAggagaagttctggacagggtgg" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2021-01-11T10:43:50Z"><BindingSite location="2758-2820" boundStrand="1" annealedBases="gcggccgcAggagaagttctggacagggtgg" meltingTemperature="60"><Component bases="gt"/><Component hybridizedRange="2813-2820" bases="gcggccgc"/><Component bases="tcaGGCGTAATCTGGCACATCGTATGGGT"/><Component hybridizedRange="2758-2780" bases="Aggagaagttctggacagggtgg"/></BindingSite><BindingSite simplified="1" location="2758-2780" boundStrand="1" annealedBases="Aggagaagttctggacagggtgg" meltingTemperature="60"><Component bases="gtgcggccgctcaGGCGTAATCTGGCACATCGTATGGGT"/><Component hybridizedRange="2758-2780" bases="Aggagaagttctggacagggtgg"/></BindingSite></Primer></Primers>
  `<Notes>
<UUID>a050c3ea-5cc4-4394-9223-9f70afbc02a4</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="23:0:0">2015.8.31</Created>
<LastModified UTC="15:55:41">2021.1.26</LastModified>
<CreatedBy>MRC PPU</CreatedBy>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  5	               `ud=&㿎,$jSuC֍
C*'љ̡hy)[Zpi+d+̧eVσYaɊ\hr%x4"m'?Xpczz'nri-}¨40{pRJUzV,^X$2'.fSDm!HdFNʒFρ8G|L^'=El'i677	ȃ5o͊76~	ռu}ܼ`clSD,kq
=LLT&+o?E~7SEʩs,F| οW[<!=1v3vS+7<=Tx8[5uLF.s>+ohOzEN<b=s,K8m>ǈۊ*?xUl.B-k 45 hd0`0T_N @	L3iL 29ޏLL:rë;jHp߱U^!'Rk+滑RdT^1ˋJlU+24[:@VN3
)6Ƽh+LD~hۿ<"ܣQWO0C0OG5`jٌƎx5x2:K~/X<t1gnC(:&G30Col2f;͠^:
5cN1lo,ճE3."E'HPY7'Fk<
ʯL8詣N`VTMVՕ6k*/W&.&|:-"kgM"T>XHN^ݥ(?:,~,N63 D0ɠ3󯳷,8	PY\T]MT=5PU2?MUls-teF}N<gL:d$&+N|>^l%Ǧx4	tM9+H yÝQtn3OJ~UDWW8$
M4iUPnQp;H{r-iTꕥVVI.)ߛ欭"F^qn5|sýMe}=<4R^oKZ(II+=)dr=;,&
qJvbTE%(<)
`xkx=cI}KkY"c|J;Ye3ݓEU#\U(Fb_׆M}2Ut5XUPP1{gY6)Y]Y 3vT~         -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  %<?xml version="1.0"?><Features nextValidID="19"><Feature recentID="18" name="HygR" directionality="1" translationMW="37901.58" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" hitsStopCodon="1"><Segment range="2655-3677" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to hygromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;hygromycin B phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="17" name="HaloTag®" directionality="1" translationMW="33609.62" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1979" maxFusedRunOn="1979"><Segment range="1008-1898" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;modified&amp;nbsp;bacterial dehalogenase that forms covalent bonds with&amp;nbsp;chloroalkane derivatives&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="16" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5929" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5138-5929" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5930-5998" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;β-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="15" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4379-4967" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2092-2316" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3807-3928" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="5999-6103" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="FRT" directionality="1" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2600-2647" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;FLP recombinase from the &lt;i&gt;Saccharomyces cerevisiae&lt;/i&gt; 2μ plasmid&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;FLP-mediated recombination occurs in the 8-bp core sequence TCTAGAAA (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot;&gt;Turan and Bode, 2011&lt;/a&gt;).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment name="-10" range="4025-4031" color="#ffffff" type="standard"/><Segment range="4032-4049" color="#ffffff" type="standard"/><Segment name="-35" range="4050-4055" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HA" directionality="1" translationMW="1102.17" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2048" maxFusedRunOn="2048" detectionMode="exactProteinMatch"><Segment range="2019-2045" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="6" name="HRV 3C site" directionality="1" translationMW="902.06" type="CDS" allowSegmentOverlaps="0" cleavageArrows="1916" consecutiveTranslationNumbering="1" maxRunOn="1979" maxFusedRunOn="1979" detectionMode="exactProteinMatch"><Segment range="1899-1922" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;recognition and cleavage site for human rhinovirus 3C and PreScission proteases&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="5" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4070-4091" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="820-838" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="841-859" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="3977-3993" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4001-4017" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-β-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="TMEM55B NM_001100814.3 L269-S 284(end)" directionality="1" translationMW="1910.25" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="269" hitsStopCodon="1"><Segment range="1929-1979" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
  D<?xml version="1.0"?><Primers nextValidID="2"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="Primer 1" sequence="ctgaccttcatacaggcccaataaagggatccaggcccctggaacagaac" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2021-01-21T09:37:12Z"><BindingSite location="1904-1953" boundStrand="1" annealedBases="ctgaccttcatacaggcccaataaagggatccaggcccctggaacagaac" meltingTemperature="73"><Component hybridizedRange="1904-1953" bases="ctgaccttcatacaggcccaataaagggatccaggcccctggaacagaac"/></BindingSite><BindingSite simplified="1" location="1904-1953" boundStrand="1" annealedBases="ctgaccttcatacaggcccaataaagggatccaggcccctggaacagaac" meltingTemperature="73"><Component hybridizedRange="1904-1953" bases="ctgaccttcatacaggcccaataaagggatccaggcccctggaacagaac"/></BindingSite></Primer><Primer recentID="1" name="Primer 2" sequence="ccaccctgtccagaacttctcctgattcgaagaattcgctagcctcgag" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2021-01-21T09:37:23Z"><BindingSite location="1954-2002" boundStrand="0" annealedBases="ccaccctgtccagaacttctcctgattcgaagaattcgctagcctcgag" meltingTemperature="72"><Component hybridizedRange="1954-2002" bases="ccaccctgtccagaacttctcctgattcgaagaattcgctagcctcgag"/></BindingSite><BindingSite simplified="1" location="1954-2002" boundStrand="0" annealedBases="ccaccctgtccagaacttctcctgattcgaagaattcgctagcctcgag" meltingTemperature="72"><Component hybridizedRange="1954-2002" bases="ccaccctgtccagaacttctcctgattcgaagaattcgctagcctcgag"/></BindingSite></Primer></Primers>
  `<Notes>
<UUID>a050c3ea-5cc4-4394-9223-9f70afbc02a4</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="23:0:0">2015.8.31</Created>
<LastModified UTC="15:55:14">2021.1.26</LastModified>
<CreatedBy>MRC PPU</CreatedBy>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  6P     '  2        2`ud=&㿎,$jSuC֍
C*'љ̡hy)[Zpi+d+̧eVσYaɊ\hr%x4"m'?Xpczz'nri-}¨40{pRJUzV,^X$2'.fSDm!HdFNʒFρ8G|L^'=El'i677	ȃ5o͊76~	ռu}ܼ`clSD,kq
=LLT&+o?E~7SEʩs,F| οW[<!=1v3vS+7<=Tx8[5uLF.s>+o"ۚ4g%㮎-EN<b=s,K8m>ǈۊ*?xUl.B-k 45 hd0`0T_N @	L3iL 29ޏLL:rë;jHp߱U^!'Rk+滑RdT^1ˋJlU+24[:@VN3
)6Ƽh+LD~hۿ<"ܣQWO0C0OG5`jٌƎx5x2:K~/X<t1gnC(:&G30Col2f;͠^:
5cN1lo,ճE3."E'HPY7'Fk<
ʯL8詣N`VTMVՕ6k*/W&.&|:-"kgM"T>XHN^ݥ(?:,~,N63 D0ɠ3󯳷,8	PY\T]MT=5PU2?MUls-teF}N<gL:d$&+N|>^l%Ǧx4	tM9+H yÝQtn3OJ~UDWW8$
M4iUPnQp;H{r-iTꕥVVI.)ߛ欭"F^qn5|sýMe}=<4R^oKZ(II+=)dr=;,&
qJvbTE%(<)
`xkx=cI}KkY"c|J;Ye3ݓEU#\U(Fb_׆M}2Ut5XUPP1{gY6)Y]Y 3vT~      1   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  %<?xml version="1.0"?><Features nextValidID="19"><Feature recentID="18" name="TMEM55B NM_001100814.3 V207-K242" directionality="1" translationMW="3971.86" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="207" maxRunOn="2039" maxFusedRunOn="2039"><Segment range="1929-2036" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="17" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4061-4077" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-β-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4037-4053" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="841-859" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="820-838" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4130-4151" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="HRV 3C site" directionality="1" translationMW="902.06" type="CDS" allowSegmentOverlaps="0" cleavageArrows="1916" consecutiveTranslationNumbering="1" maxRunOn="2039" maxFusedRunOn="2039" detectionMode="exactProteinMatch"><Segment range="1899-1922" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;recognition and cleavage site for human rhinovirus 3C and PreScission proteases&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="11" name="HA" directionality="1" translationMW="1102.17" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2108" maxFusedRunOn="2108" detectionMode="exactProteinMatch"><Segment range="2079-2105" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="10" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment name="-10" range="4085-4091" color="#ffffff" type="standard"/><Segment range="4092-4109" color="#ffffff" type="standard"/><Segment name="-35" range="4110-4115" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="FRT" directionality="1" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2660-2707" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;FLP recombinase from the &lt;i&gt;Saccharomyces cerevisiae&lt;/i&gt; 2μ plasmid&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;FLP-mediated recombination occurs in the 8-bp core sequence TCTAGAAA (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot;&gt;Turan and Bode, 2011&lt;/a&gt;).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="6059-6163" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3867-3988" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2152-2376" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4439-5027" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5989" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5198-5989" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5990-6058" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;β-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="HaloTag®" directionality="1" translationMW="33609.62" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2039" maxFusedRunOn="2039"><Segment range="1008-1898" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;modified&amp;nbsp;bacterial dehalogenase that forms covalent bonds with&amp;nbsp;chloroalkane derivatives&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="HygR" directionality="1" translationMW="37901.58" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" hitsStopCodon="1"><Segment range="2715-3737" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to hygromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;hygromycin B phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
  p<?xml version="1.0"?><Primers nextValidID="2"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="Primer 1" sequence="gcaagaagcagcagatacatctcttacgtgggtatctgcgcccaatagatgacacggatccaggcccctggaacagaac" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2021-01-21T09:34:42Z"><BindingSite location="1904-1982" boundStrand="1" annealedBases="gcaagaagcagcagatacatctcttacgtgggtatctgcgcccaatagatgacacggatccaggcccctggaacagaac" meltingTemperature="77"><Component hybridizedRange="1904-1982" bases="gcaagaagcagcagatacatctcttacgtgggtatctgcgcccaatagatgacacggatccaggcccctggaacagaac"/></BindingSite><BindingSite simplified="1" location="1904-1982" boundStrand="1" annealedBases="gcaagaagcagcagatacatctcttacgtgggtatctgcgcccaatagatgacacggatccaggcccctggaacagaac" meltingTemperature="77"><Component hybridizedRange="1904-1982" bases="gcaagaagcagcagatacatctcttacgtgggtatctgcgcccaatagatgacacggatccaggcccctggaacagaac"/></BindingSite></Primer><Primer recentID="1" name="Primer 2" sequence="ttggcttgcttttggcagtcactgccactggccttgcctttggcacatggaagtgattcgaagaattcgctagcctcgag" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2021-01-21T09:35:13Z"><BindingSite location="1983-2062" boundStrand="0" annealedBases="ttggcttgcttttggcagtcactgccactggccttgcctttggcacatggaagtgattcgaagaattcgctagcctcgag" meltingTemperature="78"><Component hybridizedRange="1983-2062" bases="ttggcttgcttttggcagtcactgccactggccttgcctttggcacatggaagtgattcgaagaattcgctagcctcgag"/></BindingSite><BindingSite simplified="1" location="1983-2062" boundStrand="0" annealedBases="ttggcttgcttttggcagtcactgccactggccttgcctttggcacatggaagtgattcgaagaattcgctagcctcgag" meltingTemperature="78"><Component hybridizedRange="1983-2062" bases="ttggcttgcttttggcagtcactgccactggccttgcctttggcacatggaagtgattcgaagaattcgctagcctcgag"/></BindingSite></Primer></Primers>
  _<Notes>
<UUID>85bdbdf3-0947-468f-9327-099d5b2c126b</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="23:0:0">2015.8.31</Created>
<LastModified UTC="9:36:35">2021.1.21</LastModified>
<CreatedBy>MRC PPU</CreatedBy>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  /^     &  /        /`ud=&㿎,$jSuC֍
C*'љ̡hy)[Zpi+d+̧eVσYaɊ\hr%x4"m'?Xpczz'nri-}¨40{pRJUzV,^X$2'.fSDm!HdFNʒFρ8G|L^'=El'i677	ȃ5o͊76~	ռu}ܼ`clSD,kq
=LLT&+o?E~7SEʩs,F| οW[<!=1v3vS+7<=Tx8[5uLF.s>+o"ۚ4g%㮎-Qk9>S:gFK@_O>(⊏#B=/ah6k  M@GY468 ;:Ӏ;o3S0 3Lw??;ήܬ-Nl @:7W`JT=U>rRJL;@쎭:$2buFbz;# J>6#t(~>x1<n?kAl-gy2c1b&^!|4;Ꭰ<AR߲70jýu6]01bY,ۮ
4L:4<üh.׹NjӠ3@s[/<'ulLˁ񃈑I|s7TM>BsÁ0z*hӦX)Օ5mիueMx
m,~N%d⯈hZuSeH> ih3ίK_#Ӎ*2h;+0m;{T0pE4bUMT=UC̣*d;m[KD QC*S3:|S ή;s	J$,S#q?8Ϧ.	Gq4]D&$0tJR>^py]&8SҟQ($	0SMs4UTon^ܥamU~FiU*Rfa%zJ}c71+odȑgۃ#a1FY_OOש斊<9RJJY*3\hCl-*	;¿\mCآ5U0/lIJ4m킘46Z-o%긇{_RH2pgdzHW+{+7nL]V<TwbiM
ha0gfbjEVWV@+ݫU#߇      .   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  %<?xml version="1.0"?><Features nextValidID="19"><Feature recentID="18" name="TMEM55B NM_001100814.3 V207-K242" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="207" maxRunOn="2105" maxFusedRunOn="2105"><Segment range="1929-2036" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="17" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4058-4074" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-β-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4034-4050" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="841-859" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="820-838" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4127-4148" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="HRV 3C site" directionality="1" translationMW="902.06" type="CDS" allowSegmentOverlaps="0" cleavageArrows="1916" consecutiveTranslationNumbering="1" maxRunOn="2105" maxFusedRunOn="2105" detectionMode="exactProteinMatch"><Segment range="1899-1922" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;recognition and cleavage site for human rhinovirus 3C and PreScission proteases&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="11" name="HA" directionality="1" translationMW="1102.17" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2105" maxFusedRunOn="2105" detectionMode="exactProteinMatch"><Segment range="2076-2102" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="10" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment name="-10" range="4082-4088" color="#ffffff" type="standard"/><Segment range="4089-4106" color="#ffffff" type="standard"/><Segment name="-35" range="4107-4112" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="FRT" directionality="1" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2657-2704" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;FLP recombinase from the &lt;i&gt;Saccharomyces cerevisiae&lt;/i&gt; 2μ plasmid&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;FLP-mediated recombination occurs in the 8-bp core sequence TCTAGAAA (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot;&gt;Turan and Bode, 2011&lt;/a&gt;).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="6056-6160" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3864-3985" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2149-2373" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4436-5024" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5986" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5195-5986" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5987-6055" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;β-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="HaloTag®" directionality="1" translationMW="33609.62" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2105" maxFusedRunOn="2105"><Segment range="1008-1898" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;modified&amp;nbsp;bacterial dehalogenase that forms covalent bonds with&amp;nbsp;chloroalkane derivatives&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="HygR" directionality="1" translationMW="37901.58" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" hitsStopCodon="1"><Segment range="2712-3734" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to hygromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;hygromycin B phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   <?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  _<Notes>
<UUID>85bdbdf3-0947-468f-9327-099d5b2c126b</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="23:0:0">2015.8.31</Created>
<LastModified UTC="9:33:24">2021.1.21</LastModified>
<CreatedBy>MRC PPU</CreatedBy>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  /p     !          `ud=&㿎,$jSuC֍
C*'љ̡hy)[Zpi+d+̧eVσYaɊ\hr%x4"m'?Xpczz'nri-}¨40{pRJUzV,^X$2'.fSDm!HdFNʒFρ8G|L^'=El'i677	ȃ5o͊76~	ռu}ܼ`clSD,kq
=LLT&+o?E~7SEʩs,F| οW[<!=1v3vS+7<=Tx8[5uLF.s>+o"ۚ4g%㮎-Qk9>S:gFK@_O>(⊏#B=/ah6k  M@GY468 ;:Ӏ;o3S0 3Lw??;ήܬ-Nl @:7W`JT=U>rRJL;@쎭:$2buFbz;# J>6#t(~>x1<n?kAl-gy2c1b&^!|4;Ꭰ<AR߲70jýu6]01bY,ۮ
4L:4<üh.׹NjӠ3@s[/<'ulLˁ񃈑I|s7TM>BsÁ0z*hӦX)Օ5mիueMx
m,~N%d⯈hZuSeH> ih3ίK_#Ӎ*2h;+0m;{T0pE4bUMT=UC̣*d;m[KD QC*S3:|S ή;s	J$,S#q?8Ϧ.	Gq4]D&$0tJR>^py]&8SҟQ($	0SMs4UTon^ܥamU~FiU*Rfa%zJ}c71+odȑgۃ#a1FY_OOש斊<9RJJY*3\hCl-*	;¿\mCآ5U0/lIJ4m킘46Z-o%긇{_RH2pgdzHW+{+7nL]V<TwbiM
ha0gfbjEVWV@+ݫU#߇         -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  %<?xml version="1.0"?><Features nextValidID="19"><Feature recentID="18" name="TMEM55B NM_001100814.3 V207-K242" directionality="1" translationMW="3167.90" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="207" maxRunOn="2033" maxFusedRunOn="2033"><Segment range="1929-2016" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="17" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4038-4054" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-β-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4014-4030" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="841-859" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="820-838" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4107-4128" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="HRV 3C site" directionality="1" translationMW="902.06" type="CDS" allowSegmentOverlaps="0" cleavageArrows="1916" consecutiveTranslationNumbering="1" maxRunOn="2033" maxFusedRunOn="2033" detectionMode="exactProteinMatch"><Segment range="1899-1922" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;recognition and cleavage site for human rhinovirus 3C and PreScission proteases&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="11" name="HA" directionality="1" translationMW="1102.17" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2085" maxFusedRunOn="2085" detectionMode="exactProteinMatch"><Segment range="2056-2082" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="10" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment name="-10" range="4062-4068" color="#ffffff" type="standard"/><Segment range="4069-4086" color="#ffffff" type="standard"/><Segment name="-35" range="4087-4092" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="FRT" directionality="1" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2637-2684" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;FLP recombinase from the &lt;i&gt;Saccharomyces cerevisiae&lt;/i&gt; 2μ plasmid&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;FLP-mediated recombination occurs in the 8-bp core sequence TCTAGAAA (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot;&gt;Turan and Bode, 2011&lt;/a&gt;).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="6036-6140" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3844-3965" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2129-2353" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4416-5004" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5966" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5175-5966" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5967-6035" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;β-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="HaloTag®" directionality="1" translationMW="33609.62" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2033" maxFusedRunOn="2033"><Segment range="1008-1898" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;modified&amp;nbsp;bacterial dehalogenase that forms covalent bonds with&amp;nbsp;chloroalkane derivatives&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="HygR" directionality="1" translationMW="37901.58" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" hitsStopCodon="1"><Segment range="2692-3714" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to hygromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;hygromycin B phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   <?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ^<Notes>
<UUID>85bdbdf3-0947-468f-9327-099d5b2c126b</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="23:0:0">2015.8.31</Created>
<LastModified UTC="9:33:0">2021.1.21</LastModified>
<CreatedBy>MRC PPU</CreatedBy>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  -                `ud=&㿎,$jSuC֍
C*'љ̡hy)[Zpi+d+̧eVσYaɊ\hr%x4"m'?Xpczz'nri-}¨40{pRJUzV,^X$2'.fSDm!HdFNʒFρ8G|L^'=El'i677	ȃ5o͊76~	ռu}ܼ`clSD,kq
=LLT&+o?E~7SEʩs,F| οW[<!=1v3vS+7<=Tx8[5uLF.s>+oQk9>S:gFK@_O>(⊏#B=/ah6k  M@GY468 ;:Ӏ;o3S0 3Lw??;ήܬ-Nl @:7W`JT=U>rRJL;@쎭:$2buFbz;# J>6#t(~>x1<n?kAl-gy2c1b&^!|4;Ꭰ<AR߲70jýu6]01bY,ۮ
4L:4<üh.׹NjӠ3@s[/<'ulLˁ񃈑I|s7TM>BsÁ0z*hӦX)Օ5mիueMx
m,~N%d⯈hZuSeH> ih3ίK_#Ӎ*2h;+0m;{T0pE4bUMT=UC̣*d;m[KD QC*S3:|S ή;s	J$,S#q?8Ϧ.	Gq4]D&$0tJR>^py]&8SҟQ($	0SMs4UTon^ܥamU~FiU*Rfa%zJ}c71+odȑgۃ#a1FY_OOש斊<9RJJY*3\hCl-*	;¿\mCآ5U0/lIJ4m킘46Z-o%긇{_RH2pgdzHW+{+7nL]V<TwbiM
ha0gfbjEVWV@+ݫU#߇         -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  $L<?xml version="1.0"?><Features nextValidID="18"><Feature recentID="17" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="3950-3966" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-β-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="3926-3942" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="841-859" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="820-838" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4019-4040" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="HRV 3C site" directionality="1" translationMW="902.09" type="CDS" allowSegmentOverlaps="0" cleavageArrows="1916" consecutiveTranslationNumbering="1" maxRunOn="1997" maxFusedRunOn="1997" detectionMode="exactProteinMatch"><Segment range="1899-1922" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;recognition and cleavage site for human rhinovirus 3C and PreScission proteases&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="11" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1997" maxFusedRunOn="1997" detectionMode="exactProteinMatch"><Segment range="1968-1994" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="10" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment name="-10" range="3974-3980" color="#ffffff" type="standard"/><Segment range="3981-3998" color="#ffffff" type="standard"/><Segment name="-35" range="3999-4004" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="FRT" directionality="1" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2549-2596" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;FLP recombinase from the &lt;i&gt;Saccharomyces cerevisiae&lt;/i&gt; 2μ plasmid&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;FLP-mediated recombination occurs in the 8-bp core sequence TCTAGAAA (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot;&gt;Turan and Bode, 2011&lt;/a&gt;).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="5948-6052" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3756-3877" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2041-2265" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4328-4916" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5878" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5087-5878" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5879-5947" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;β-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="HaloTag®" directionality="1" translationMW="33610.39" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1997" maxFusedRunOn="1997"><Segment range="1008-1898" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;modified&amp;nbsp;bacterial dehalogenase that forms covalent bonds with&amp;nbsp;chloroalkane derivatives&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="HygR" directionality="1" translationMW="37902.75" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" hitsStopCodon="1"><Segment range="2604-3626" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to hygromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;hygromycin B phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   <?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ^<Notes>
<UUID>85bdbdf3-0947-468f-9327-099d5b2c126b</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="23:0:0">2015.8.31</Created>
<LastModified UTC="9:32:6">2021.1.21</LastModified>
<CreatedBy>MRC PPU</CreatedBy>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  F     @7zXZ  ִF !   t/ ] ˇf{3(1v%f M*	mj)p80*jBJA>f"AvӒp&s{3Th$h|=27|r6
ͽ;29SNx*mq:Mҁ-76)_g+TST~6n]JHbG>7XN'tI-QwIwj{rcZ폞<T
]0)ʞ֎45j   ~ 1dAU   rg    YZ  7zXZ  ִF !   t/Է]  /.!~;$}>樂w6JH4OOf5̄iD 8O%I+'5`unO}gsݛ,F3(틝]oҕ=&EԚ
)Z2|!W&teEIGu^POܮk wmVbTƄ7\#i!27>Jo˂A,EӘ2JH#vDAE<3P_5
1J":raO@Jt<:ʲj|hmFg^ф6UrRqDcn؄& [=@i>݋&|#͙>!#$T-lQ8erM\X
ս2-j U?cohEK2G"챧,<S8eRGrRѝTkۚ#h[EڤvWW+jՁEUAEN#8j,jH2Ǩ>kux!Pc`@!Qx3QE\W}C?n`,Yڽ0jrh֫l ?<Z"dkcߙeUjiqAa5! vvͫ sЪkH䲦/9,Ν)чBF&o˥N_Nͅ'!z̂?W'k󍊬+}q&Rl]QWM;; ^Gp}Om*Ccwc !LuhPFPqJ>N;Nr+(ekHFY^oh,w|"YpP̊h#9,Ʃϸ9kEk0IŅmlz`J\ҘGާA&˥A:рg̔g'tC@IbdZ
^PNZr7TƁ4QIFr:Y;$P̝zboJ'0س;I-3Q<]]1fO{D4W!8M]JN?fm8NږoZ$Z%j;[ϼ<W &`T^/"~5"sC.;{F
M~8.y,	W=P<M+6KiulOXNfR_BZ78;GDq;'%6 407἗9"\)?n)ԊQ	kk.Y!xyl<c#|B .Kˉh,,nOȁ\l?uuiU(*3apՎ??'.$4A]R`7M+/+-E7댜14a>^r(a	4pmnvy;-`.w~4Ɖ{ClW"ճ+Ud[XٿѬ$]iDߞDd&r6$q\n2T7(79%s/ݶOD];	i,vj&ŭ\W;
]3i^=)j#h-򿙚͹G3Ǽ/<*|jN$. LRM<WɈpPS?2lg%H$arqjIErqxm^RExGkNf*)c'ȋI#*|P'EFO.!tw1I,ݚ/T?Uz[Fy7#ugii)s}0Ou)Ub&EV~)n>Z,Ņ) n,d%UM[:ZY|wŔpj8|Ҋ5[h!tд;w Uh4j3q]>8۠/	Pu0`!wHlag6/y\ˡW~1!S%l	HUQ54#0V 
0?3& Hl՗@/u3v\%#.8ៃ= qAb+^1J3	甍wZ(1oXlj9CQ&Y?[h	Q=y[R*6J2]M1MYWA/}fv2h=|ZF/cU>7CzP{0?{'[;"w^ >|C 5 C#-$G Fc|ӎ43AcN_JA-'R63D]ݥë:Bf4̝䜜oѭ3eYD5+{aJC-7g*ςkӹ.մM]ʥ;o氵Ӧ@p5\Oޢٻ؆׬zb\KdeIvz^*WJiwWØ? 4%%'qM0 gƃѮƺX
C_.;nP5;l?JyC9{Fg¨y74ͨEZٯcL,hIw)~gln-FIVGWϒG#m#pK@=wmwč,Rl(|zF;CT;qF^nPce(Ԭ
4gIJACb0⯢8`i%G%c[h<&6z@W4V;2&\M+V8
J.uNo1qIu쩼Z:ͷ/q|'c~yrcbdwuo'Ta7U6sWmxnس|;g8X\G=ua#;@D5Ld6yWbߘfIǆFʹ.%v~Tqe1#	tNZzS ħUWnaEq̊ZPA/V4TvW3.xIQʖü.**_Jl:LD 810DT24"d!5mg\3e*~y<w׸ɫ99_{wN>8YK>B+A߮(K? 4chAbo	Y)AӋ^..{?ieE 'q<g}V7]ó{YÇ[ Ml{m;X=#H)Qx˚.dҪ,iyoLخF2@\bhLug/0^9x3;L,ԽL@}Cr I"PjGyFBJY/PNUVNit錶19+la;փ9=o*Pza\uX*ii]/r>YL#Ĕ`rWjy$h
#-K0mqQ81U0ʺg[5)1C%ŧ܂67ӊvxsl|n)HVSKbힿT	]e`cRє3zֺ1p./jQLK-j{b{)pd3w\sϳ}8Vʊ8ڴ.Z'xnu`7z.G"!Lu}N<Clovh^;pieD<0tczVxlx20ylzUjMK3~uw3w?[쇅Tyj$ٌs -?Lԕ !/"6#$p1oMb:Bi!{L1V@ƭgb.a8]]#<RQ |KUo<̴vCz_ RwZ81,%ƈ!sL=kXa4:)ܝ%f=#4Ц5H{"oHqʋI C#(0fE3Yi]  {])tb''@4Y~bעr'\}u{4*M.%q>_F6Ec7P2;t rڎ5NFwV)Qsyw^:kP449fZA\WzZz#Dުc(&rptQo<c}瞀a4)=Lj paC`0{8XyUw!89Qт!zrs}D_Wxʈu`<+ϔ٤09%NWS*	ee[FCO6{Pm|0U7QuCL"ŵR"9g(!Hkf;7JsNM{J
wnK}W	E	fFBAnav_zW4:hG)/ SxdЅpDˉ9ASO9/mT`f?;=m'UL˕ .
$RHYL`ӑn<V?Px<%(3ֲ%y5xSUY?InGqǸ5mSP׹#!IҺ帛j0J`	SKsʚ5PA/ͅW;<P}""n@`fo)wi2ÝCZ!`,86IۀtEn.lkGw1M+T--B_F*EJc?3qஏ'ĵ>\>oLT"FNvJƌnqv.*g( ѻ	\ն#<?%u!#kI".CKt1w
 %ҿSD̊sZ{x׭3UbLOfE|CKAAcMe/RyM5sez6vBSV+{#VqߕKxQVL#uwJP/pU͍(yk:4ʑ.$y8p_zέ%;V ODI67aW#N^ MYK|J 
ZqmrϿ5m	~׼0NhOޔlf#{T.}yi7듆5}oA&X[ioϥc ś6pʨMז>ǼqXJ&T@I)Ho#G>-/PU5
Au7A	5G>u@'I\kx|͸5RMcuir6.>6i)qoS6B)}>=y>)NR"GA'~]_T6{kh}3ʷjC~FUzC5D(wcVk]8	ަJlVgֱE7)$K3b?V.Pl-73 5z Iis_BD4R_!JFHn"V:'QrY+y"D"xa>7Yw*Y*Dz?^}Xw2n֩x54/zV4>Q}f ,9XI,')ԧPthNWyM;Z{	dξmbXߕ1&PhK>{v Q~r]*"ӁG2/pafo*qg4QO+qr=[5WUHģde۳sAn_{3iDNV<j
"RC$kG٫&;
ѐJKϻFY1`oΖ;̈R9&m_{zDFtFFҋʜǎk9k'p.?&A7I)2dXp A+(r$c;dƍ)3G<r+ih-wu:G6B44sW9Q7-tkYN._6eu)<޶QXr6vF
s|O3VCEya$Z[ :t_<8a=q81aݰi|M?w,ƆD~UqR?B5'th,`tXZc)vtQcNN=>U沲#RDmEEM@b`hm^U!1V	v{7Vavq"t"y4+[[9;b~.Q$9!ź)ʟ{ %hQCN74GI(<X6k7l`w2OSŲqJQV}442{cwou%/tsǰyu׽&#K8ܛ}OwXQe!a4!܎	hh^+lsAT%5:XS3з}^D8{)i,53nO&0]|Q,8}l끁R>	Zz=Kq|XΚΪޟ:đJq=Ƕ4$&nK>gT=iR[X<&U2R$.ӎ!L?XUm0--1hIf]~58wqV`ad]>j>>U%3!iY=ݦ@iUW iU(:#ju8)K5B^%}#Ii9Ԛ靔AB]t|yX5X8-0),ԁ-ӷGsS\wT"[Rkܗ6KV+kiƃh-.#'3'jE#krK-z/<<@hwU$u~ǓQ"'.R4^on;"Z<V\X\x
>Ā׸3zmj51$aҮ۷4PhOVr5e2" $;_;h6VZdNvs)FTG
@)C.ΎRa5c"{Zd8HP=5Xu>e\6+PA1y!GIKJе*/4~Au鸽`K>#Wb[[d8Dg ݇Nsג`F,qɆo3)݀.)`(5K(CmGXuC#<ծ͂E}ts>KYqkbٞ&>R$qBLݦGZM<	<gj!((hjbSy"Kf_/bgռ&Ln!ulI.lx}+7d2Ï'N6hfNn͔n"{3"@'!
g+3;X4۹Z%^v)ڸz=
y ,s8Dw7}tHypgD ^a7wfAL$iڸ1wŃ͂ 
GGy'~_ٙ_l,o`5NL'lQXwɱ>d(㍊1wt.4{ln:h?mEf1znȱ0lP'g1?ol9oлz9):]zJQi]mݺ/]5Y|n27]NrxRbhYK"Y[.E
trHllN&JYr|($k$ye+lGfKA+QX+ԢTY4ԪUQ7 0UAysw"dG5ᎢY,Kn<}xHܓW2@KݣoTZ<h+#A%v1ZJ>]pIWAzff/n.ʃC	p?7[eH^	9{ȵƮ$μ:$?eSzsCS:&GWVк#%|4&!1ǀvq`>r 3l(J]DεV֫KFW+h41~	0CʑJAΜj*e-R44Husi!=
#|2'l.ԡdh",-ɕPlŉ⓬r0H(e`0_F'kL5%?溚;<ΰ\=,CA'vў	8
P\~pgb-6
ʬE%zdq\(UGWܪkLN=h՝]P4kEH& lB͐9]MꑟP}sUj!Vr(qG U%8ˌuێ l*ua+.$Q)TNHbF|ٛd'׷UHk&Cl7m{jO
"^hU8֍lHK'W.1FDF΢AGP̫̂+s*ME#/jMƵ4B5̞M|`,=ߩ\T*\,9.PY0:uQ!:$o)`uY
5c7BcY1E3O0G̥)lݽy˂yQh&!I5a1gP]ou}Ѱº ^M~
 ё^dn8U(t 0f1&T߻@ETZ=Ll@>j	^NK,p"Ftk3XQGtDqH/'TީM^m" 6ӾExk)Y-'{~s{ 0j>r"ɜ
\þ}*bIFuA.kdѶXW\/muæ4{4Y?B>T7:qb%di|zQ1|҅H?H;FP\D>MC>a9F~k[vo7kӤ6*-OZ]z=j5?1{V%m~1LPojG0
4`Ѵln+z4{eXq>[&tU(dXTYZz/L%4<^XyࢿP'!e)V/4meJf~>Mk m=.]?TV ]SԀku >&1%x
D?(74v+; ?W\ٗ'+09d+Pw^iBn-FHR@fmƨoS$+cka2JTUS=\,KT,'klA/LCW$,~[QaT<$a+gޒ,Z*G6me{p}G}L!^Q,	J'sw=cxF*)uCRfw^J	\ici;}E={,0%&nv((	GgrAN(z	)z)@b)&RrpDN ^?U7+]/N
dVT}2^ψiP*|ZY/^RH n΅/t".~#l	-
	jJTUᰋ0SJA_TgHΆZ\B?I1u4suuיG.LŇ.vt+Q$Ci]ܛǉԱ3;@XEkفߓ
3ɷ#X
t	ו6<>5p\3ՆLon5A,l@}LLDxK`XtsI%U:__Puc(9y5^PkTJ(RUfO{&jD[./$Fy![bY.tig#2Ia
M=KeQ4OVζUMp[S[$_3Uol-J5Sx9+1%6HWUE!1Jh8A9{&FBTG~Id$IIXmj0SccHb7ؓ6yg+bNH1ttNr
|\d`zfܡ6h(\Hz$4g st9X@l#Cg@MլMu)}`~ed!
[6,?qdeT|ζZ,"#@:d pejeRJ~("QZs,;uq0dSత&C;q#~|'J,4$(8.ÙfdU4k`ELA3;tcbc_uPdFN]=#W&ܷFh}vF\c9I&*&b#E֡q{g֑^c^?DzqD͏&~ާJ҆j6^PT|ڳP{IqfLVG(,lwٻt<Q(ݲhdߝJ ֋)/s?/nu޳}  >ܪ W\$­*WWxƁf\cdzh# IA}gп̐6~Z2"صoc1MH`+pClhk[Mmkv{_NMmqi!htmD'hH!3u>V|8|r & LbC#5K"zIs
U#PmmC*̊dJq>$Lyo2T[XKptUexھR5F%aE6y:a)I	-Ǝ89/_q>>cWGE>s?L2hˎB z"_8-Ǘ0ezqTF6ǱXz^.K4oApPS솣DiñUʯKvl1fZKd=I	˚~NvR&RDB"= f& mׅQCgq]xm9t^ߘמ z&X]?7RiYvG_tԒ{1܇ЭR$Ql<HI4GgO6s+}6V*w
'`94,DUy{LrH
]8<ؕ*?fZ]SCX"!ݘ6v`<̬x.\ruEOmp0S,݂vhP<?JNF۩nf}Iےc1א,.U>!XZY1JqWP/RRO~Ρ.`pF^uT/hB7r^|<.2[lskzX*sϏ~0%:JZl;L5}L)S漉2&$!?Ƌjޛ\jKgHrRuO?ɲ'1ɨ?+*}շGݍ&D)9ՉCDW)S'3Dl4I&.I{]*GSe[xwf/E.ƹ"(k_m3(g/^Y[G"dpg	z|OT06UIgTtSp4^Iss])CԷ `+귋VJ7썺Jl(ドDfRX7'ıl'6mMlW	b̏b8opT13b
KV2$K^
>AVQ擄lk8+IE%8"	|T`EӀYMI|˶TE-;T[ |Æ@&_]һ-;9K$A[c8 OmOvļJeZ2xcLS/I%^m|m9'vlgzc|L1[1'V4Gk#yt/Ej&WCP%@Q}>N*lbv_طʶuZI5,ƩH3z|Sը%AɍpT&A᪢5	mYaհu(kKӥ4+lA)ч9 `SxoBgsYq_ĄϘ߶ɄNTRѝ <F]i:LߺkalNxQ;nYo_4&nڻ
1ۑY=F͖h)ISoa&(=Wy"ۼ2uСapA=7?wUŴj7`x
lARE7|(,(lT$o
9O]!wI($ QȤp6e=ࢨX8ET8ȃ<J-5IXAА1Hc~j5FLZ_)
230ʦvEI?^d2iF8?в2oˊOUΠ!)P
<e+齮dRgpf (-t?`Gr.,uv]Ul*Z
Ri7Q+n'n˝VWCߖwU$-J\!4SUSdp#c.8ۈ1˒?dD-ZTpA+섁 
xUA2$[0<Ak@c<+5ȇn3_v˨_W|ϙ_CWE\Q#ͦmw'"ARh+>]H.wjp18i`G h|6"GLsFM(CP+3jrF,:(m}1mğ]~nv#}U"K~2N[:
AYD
!:y"0~Je~:Ye;2}xa틸R(ꑜ)9qH.	
R}y5{ϥ=a=e-x}_g%wk܉clDqxov1qFa0%82XlDms5BKt#td˭{ͨ>w^e c?UL.Ja&NXBfY;A2YpVd$z31ܘGS&/ez'5$;2C{|,)iTBf4cj(adūOI{xx%[|"v<|n_h.+lWU qPӝvVw-F>.T{xlvF^:6g\fvƌ&:0uNAu	RpM\	cT2*>4	m>aOe>)b 
Q]9~MW[lv:Nr+f$b>g_ǰ@G|$'>҆JTnw 86`)u77%Ĝ wZ䏧_ YpE/ʄUt-sw1L̐&#dPq )5l#Z=J1=>qi:/
$;(ѵGQo䱢WW_2]Vgd63We^e3!	4\ :tCY`ǚ]CIAV|,>pv:!s2[PfJ',=IDyE%UTsh~Azt& ar(ԛn9)w9.~*nu^-4O4QktB	GNg~_`L?+"m2ynuo~NH*@u垣Bolms>]0)&0 S('c`-epWB٦/խdMߒBbjy_a@վ}k=70k2
gF=WcP7-3 b-/YQ@z8Vl%п.?5	K/F@Sg9ܻnC+^D1J	0IƝ&&K~4ŋϽﵤQRڏ_"&W!@Eɜi޺rɛ. 	R#h^	
[\k
`fv 6R-]G+rP^W*Eo/|
DH1'X<x9¹t`(ϕZM׏KJ,@Xoљ&G(ρՂS4]<|tH\4g9ÄPAyS)RcO,<̍7Т6, f2X76rq|u\V
Up9(x[}9;w~$V(F0[R`s8bjG0UBd5yOz%+0#JWM;ÌK|)W_c|FVA@-RW{n:G3 Fd[Ix;	6K-v0¨0+6-]"p&շ*Mvvە%m > fz-~9EG0'/i-#ؙAM+hk]DsPHl)`5i85}vFF-Z+^:`6{0YGd[U
-Ar<M瓓b51C~s  Ԓ8->ME.la8Y	嵅J`4QyO
vfu*
p,7KfYABt{
 `eN4Xo]ʹߏZDM.W&%&`r"?"B׎nٕ CU<K5ͯ`VH"NcZ6QQ!k,rI/C)ѐ,j(xBfæ?BX@jEr Z4JM=h2'26T<#ƍ|*e;43tmj­ߣѓy=Cvkd^)FPIV#Ԙn4Va,^ȹ	Yo>e\'N/ڠB?/ح1gI瘮%hȔ[4*)]ps`>2S<ŦYFϒXG.=nrj#d3Z&"4W$/XtX2q{R՗!e@')7>'HvX8Wvlŝ#9QniV,qq4*N}+Y|41%P;@Fl?3r^[UAC§
4.j	X%yb. ਎NƱ=HuB=̲H4C/KӧIEAkq׍B3Ndz[^;ŪA^o$ߓ	3_~^^'5tcH}(+ACg_x}<)M%xmuy\Ö.x3~ @#~ARg-waT3u#y_X.PՕdqqcؿX!ϛ*9 GyLgqXNM6Fܞ{K2]2],Vv`ssYC-;A̒)	m%"cjMuTdS3<Ǳ-HAj*>Fi/]Zۯ\~s1vGDW\E>C'˩g.N⯼Ri65}**zu1T֎'x(U-x{xKQ̔"']ލ
ѦzSyj\JK&7`=iԲE68BĢ4?%"jz<^s*x';TdJguB_Y+1NЛ@Όgʃ vR'@eZks|=:x:&
G[ԈXH5pU$8;^֤d_k,;ԿB&1l<ŞUyQ؇!'Wߺs(5Il_{1jpPup/J
PxW}:x~|4!I|sF6>C{B:ANس6\in%?iSfp
ք~kWޣL1NDjEsD=b/C.$TEng澯ǥɂy
Z9Ej׼hbKZ΂5ѐH^q
Ӳɹ8+Г3$S? i?NHTjְÿq"Urѩ3*HOԅ-NV'a 4
-bS#Er'vcV3*"bRVQC'lu-'5ȡ(Cɠx6w 85@>	J 1dX/Jcц7)S8l+[K>cg_w$ xīw<D2vJϴqXp3:oSHUtP:'vi*~WgG:z#>e%7[{Bb<݌gTD]:fbnV%_0)\7{-sZ&&j~ܭ3I,,Ya/WBFuSJDlo#Q]d3(~ς]ڢO#sbn;Z.3l>[\Aݟ0sodu< 7 y HUuk#Snx9ccKS4<jq0udx_ 7T(T- ,(PlԀ]v6c(ꈱL3Pu8Xljoз= ۈvRv&FL2#&:I̱[MOxۢŌ0&н҅#
#Շ}a?T eONiIKXg{]eCFSaLymȔD!~ЗƦ܅ ѝmjY<"ՒIrt8[%THńZO2c\m)-7ʐ&y/Z3jq͛Ȝ(dC#`kRPy+i[9~UdqKQ̹آq0j@~Ua\GSjv.=B$̚8O[0Y#4#Lk64CԾ癰'DF$c/|u^6,sD3zݲ]VAv=.<m=dQAUref#F %TH?emy ;PUYZξш	SO٣?m umCY if,uPتKOmM|ROGlgDi&an|ʥy*DQ<:]-XY-7	LFЍi܊DC0GNĪ4V22`!eJ2؎ [t\N.GC~v 
O
Nu` 3ⰽi%<PIAL[El߹ylH5DR^p;ֵ5̷jSK* ٲAMv=l#<wɾ2\Y5@EaK{G< 5v+إ"LaDF)
,ut1~ί"@Vb\ck}-x^<qڒתi<p$5`yn֨7CyucFF%FC{ .yxƴS$>TpU$qTG~x]D\RrΑ~H<LfLĀ^ͥWUsHDr庈UTNknŹ_ di04brr]m@O-\F3[CaiU[tDפYJ%N|	E)I0?gM<G?*nרA.f5ݏj){B8u5wpɿQ@qpd}i_KBQ^TJC;yj6VRFHt|!7,Dx(6g-g(ue9TdcFj.@u%=7[ba(rˋWx~p[]s`3}p5@e>Tj},\2lMe7Z97.fN6swl
ora?R8>σVb'չ4soQK9xrKnJ~^*\)f2ji 2]<;'IiPa@jVUN)R:Wec`V
cf	Hl-OJ*81W
g5Ig|
^FamNT(&cZ8ikʢ'ׯj^5_J5Rhv=t\`D5K͍ks4L`IP,Ah^\Lf	J9}A@ 5b";znu$j4 !aPuu `gb;uY'DҒ'@!Ұ@T_	!ZnjaM7'jIN6-LT4E)!.EIX8qCra`qPA{)!&6=
Ο)(Rm`8J,E~3%%K	 ^Z`._ '!gs(b[9eƺ+ݥTTyμ#ӈ)%(A$m('|boQhj~$+=I; &;8$FR,PUM '8[	w'XY1*'|16BDe!хQXY.RVggp0;φS ފ'EJpXIMh
AMT07xL([rDҖ/ϟߑu:]}zYRa|#j	*@ZL4m7G^oc"]oH*AUwU6"HF]?ǀQGwr8iE-gH]Y|;u/fN|USl*$i:_w/CoE:jz	p:vŴ|>΁8tՊf8|_CkA|.I7]+dt^w@3(:xt/JZ|߲BtUҎjE<pmo_A"\4^U}iʎaeE,6tVgh(pG{۷HvIi,}Ϛ'Ǫmd	qa3l*S(X71nSKBz`
^iNAky
vi-ǬP809 ȴۋF0??D jU
2MŹI;kCo&_s?^
@B,I6YMb`"pP!5קL (yզ\=B
W9'G?xd
ڧ L}1^rfgJ~+&@<]7@iEALH~H0EV d_)jhq9BJOjT4liO'GepzƺƙU͑gd!,sFc6>929Ѷ#$kjrwFÉ9<yg() lb:VI;=u;!Gv`c(S#|?C;x!U[?{ 3AqI, O%E/WcCd۲ڈsle3,ٍ;-~J>P5ʅw>^s Fk円--mg	!#Ǆy(5EE6¶f\QBţS*[EnUox3ͼ;_}Zƈ-;8.׺X^Mj<p+jmWpo5;ꥺ>ŖRo{π:K[Er
SM6z·r`M 7A8/X\Fi?{aZB
+NE<XOh4MKB6=	 cT訄^LP"m6]Z	``W/γ%ߣ,$ϦL$ʆ%]\{.Fݯ߸EATP_ح+[5/"Ns/%K5q]ʜ$>$kmҕP^]c4Vo! AQԵhToH
Eŗ˞n+
7`sX/0TRumfCXi1)7L]~FWk6'Uo	SQPzkDB]AoFS }POdX*YH1XLvdq^-s]oͷ-$Gpe!!{GBs{dm=|iw=hDyS7Qæ"J_4>;K>LV Bq6eh%HdJM`-$ޥg{+5hҝN_PmpM^|:L؂tSh! qA˹ UBt5\sttLyq*uO7F'xn:X>ciiX1B77=a[ʖW^Pkp/B iP~b4tT?06wCu3>"	rҏhZU+MBHYډ%%6JIݩ&5ӂׅc"9@FRjԍEX^oR۫Y⸹}ZLyqԨv+6Ŕ
?[et#L8(&[̛ŬX(%nc߳Pvm^XsRѣj#D<V<zK:|r;)ʽ6ݜN߽tx7#^cNce6^+aWdW~]CM|ҠeāYveYM=?d2
r@zxbCHnɁB2C5\~~l7:SH]Ye[;SU0[dQE0h[cQX\EEuJriZ£|w8M&]\}=2phxL9*F937
y3~Aێgw{B7gr+ȷعUqؙ㮔wm& uNH2ݜޜd`
	3˵z,44p?qfRbV:$zҫ['bk2SH+'ÍDq|H9FI_b4L0iv	oĩ[I*,R XIijRd5U8%)t`kmJzkEy>dXr):ڙQ1ݔ~i7.B$B+70\ێ}"`lX.vՒ=(XŴB۞(%(@fgV N&Ec:KwNz)Jj?hOq!BǏ|;ވӖRNQ)#WI\RZP/iňQp(-nBޛlݲPziLl4h*{	U3i8)9.iK=ILwuίOoa8oKc4\A
jRmD[iphx
*6L	W͞@C
t'bS{zv6*$,Q7"g^YfBW|՜t1;J7$םL=tS j71X
/x1#5Iˈ?tPBdkL@z#o:s˾~mK)?Hqi4[<F`CۉJJ!+kL'cfAr~fr]%;Hf3a16R謪ldA"܏ WC{TGw4I7<g2-nUy@).|s	{!sQR>ϮK,_0GuZ*h ICD빅Vmjfmuq{2g	^Վ}i,	~#Er}Yj,ѨO3l딵(+6}=,qrZlw<9ǖ<uӉ;{H:kls}8c[SMl`:/r9jK]NQWolumK$u(w^_Ѕzp`/_һ>5vI7{Pe&1rF,S`6#PߚGj? q~{wI6uFuTrq ^6&9L`[~*eyӽ]F&_	7M@Dʡ]3q Ab|n3XI7(4u+JQ1PFh7աc$qE݉jך@R˷?N<bolRw+,?؞P^&VCGޏu3~~Wvp8iY={K#/jOrނt]o4[o)nO{)$v%+u}oha25	*:aNc4Gw+g\HT>TlvM0^_!sTBLtTjISUY/Q$y[l!}m?2"I9[k27Ś3P+޺NmvTS4,i0߇"{,O^厗poVrvV6")ܧ&w5>VدdLiF#kRBzg|PK̔;c7%',M~YŎ'0$s
*qPgfڴWqAs'$7%w4k҃]%" 0̞rn5KO@1"-?H94Q~/J~G_=1l[wʄ2/b/Mk2Aeqo_#:lޱu4.T_O	϶PJOGπk?}pRĲ.i6$iI5-F%1oGaZpqJvx/~dv +Cڵdk޻>1!
{Sqsn_
@"wG;`MX}V@%Hq>mw)zLM{BE݇dw$B#k@8E&=ֱIN9j-%i]w}AjI?Kn3,٪0PjF>ɽR]kb3i1brh90K;J`3g&:l1S U2ſ6BRmX%?-@`Z"73OG]ZoSλ&/e0gFήA|qRoq=NԖ*t&S_bPŶ6!#]ע.tꐕU '	6u"f`
{w%pJ$Y*F)'wE+\3&s^D @.[AeR{_HWޭ4/W.ͅBy80?3J}ji2BVsB{v's$jс2v#	`}'ސ+-[^rԼL*%!]E=`ξ+|k)\dTOmK'i`Zeyd8b4~aaJ;er_eAbhH^ZdUZEwe8!`r[74$Ew#K-/Z[UAi>RmbuSm`"K6Xr` &Giu֤+pzDs>]_FF!Mo%G=D/#r}9P쐨ϩϓQYBlN1L]'{hYۊӉ0EHi`tHC.7C͂|]9qL{c`yt0MBCny[֥$O އC7+FiuS{ލ6-J}>-P>,E88	ZGcZ6?S['lH}_V:bM5vqԷAq`[̤ܚ X3Bf" =(cyѬRi\.=ggѹ1q똏I,[})ηx\[⑋ɴr$fOE5ul#[-CV&Ǚ?ɓ~9|:1c=e]dyP]JNt+F~ I8].w:Mq~@ib|oVܛC8YRa,_ٹ9>\#WPr!4ҽv3@/@Uv|JǱxuIN,Z75?$&}KYh`EkBF~PofV;j-3,D}a<Ի`<}iwԣtz1*˄f+`iUśRlfj!A+A/y^lu2tbNY_	3;8q6lh25(E<}$!UMVx["8ߵ[ń(^$uŲ|Ak[є'6jB`E:H#DKnQYe;թB%{e4}|7=:Q(;Ӈ<8.	/jܣ CYfqjZ"3F$ml`@2m9Dh	
CCC/-CArk^Z7B9t)i(wm+
B;RcO,{n1eo8K#Vx4h S''#?S1jiMXl}-[N:4M98Av`f'=B(rmlTƞ8!vwIxl {=}}ڹQ.iF SCSX=΅<%T]cCoVoግ;B?swuD#ɐ
p)*Tq6h7y9eu ~2UJf@*Je#&,aԖDnoJC3b(d`h5 %>)eL-cı4޸㴬S*/:0[)ƪOvZt~*N
8x>td mqawϜhʌk8 {#q*^	<W$E@u-P4+)mWE8Cwỳn71Zt/q#,/\''},F{P,s@wrނ.S=qȦjLqVӬ:֎ %KӓdC_䡐:}0iQ#FícYwUr3.O'ypƈ<"35<4Y9HT+i˚~*/K7?ejOOD4$<W.F&*;x^ԦKCu;G34tnAUz3r>I4v*jZوĻgDbķFHduYĀb독{B|@My ƪS/!.@Has]OGo8.־)H6hlFv<]s֠/$X$XA>%I*}xڱ5=%7Hۡ3`׷_q7_x-Hw5q7,%~.kYjc{w]<4PBqDz0ci<Dql6<fPt(&jw'X@LX\{@GGtAӵrߔPvP]!#T䛻\x`f}¡[T=彤
}Ȧ!Rqs%Bh,k4Noֺe;2dp=ˇibF`X/~:q jM|!j'W*'ra.Y7j7`lr">CJ+azG=f8ݿ
2ȴJ7PLDh-(kߨJD=**3h4/7(1wckm5A0~I}n˔&ءARI]9kzL{a>~CKMk1#/c݋֝$ngdhYfP.=JyN8
)ᴃjY<jbU.RJ~7y7<r[?{!⎍Ɩ&kZA"&b>`DOE,P]LɫWqׇ^zUPL7S^3{YW:2x!NgO{7ot7dFTyf؉Bh,f8F3pM_/ԁ*$N@!`1+h;75^K~.l\Spqw{ҹ'R0G*@9R]/z=qV|*Y ɱB8gr48s6qȞr6hg  i*	8ְ-(Ga#a.d}CngOWOp6`*!uÇZb.3iPp3]CaߟJjpO<FkYyQ.5ѳ!N_GTcwQnwX{\:т%I.s\+lq+ ~_?	,
DC/		舘X<~Bsa2"t(l|1t6
}WN"a͘ԁc-*5q$5	Q~竁qBĮ k_K1;am qk
[qcc>dcʥ"nD:Gl9rTo |z7.tӽ+wB81V"7:[';Vg+v%gU^bIn./o~A2B3c$QW `~.FC;է PW`}hb%Hv2,EI)<e$SE6[:-|ʴXb㤨
fzh^R3ԙ<o`"cR]i_;mMn۩C7cܔyA^2Fka!f!T&ܩ{eBR7*4)3=sw,Ch{Jl,d2?V6o0p "}<wTS3	F{)4԰+zP4yl_1bxI$	\RBĘ鰤fym-@/289¤Yb-L"!{X?toUg-Υ 9\Eoւc,ۗwȠr׀{;'{9%-ק 	(zE'E3AE=/Ҙ Pxob*l;1O0ͷ$^>Tf瓪mXin+ ʏZ3jz^L| sj-An8(,@Eߣaw2m~~D>1%,B~y	Dg,)̼="=셭='4)!5[4Sϗѫp> V~&YOԖ	;pL~Ue
'ҲIJUHpzAqbcHIcNLC[DY?!RRYdV>NI<q~&8¶;r$G^=MFR:JO>UbN3ssMC_fӆ9q_|FXjAGK|D&HN)h):*hLio\ok|'ը
eUrTL\)ӧa&:*]}BqOk{ɌZ ڳnZQAOɘsYmTSEvu*l@9̮VAzn {lQq<Ӳĉ)8dYkC<5~"_|IQLx\#q+T)JGOMF[t'37:I&Lw 0ge
zK:R{1u,%0¹S($ O;"@ɒr4_BKC*g2ÙXBR($>?[9z,zOj0}I@ȵ+^FNFM-_|{wQ$v琺.Pe"萹䮕F',`=0c@X/5|wz.,LZ_*:N"J`{$4Ǎti))L0ޏ+O| f}j;>|w X$/?UWD4ZW<S+\+(Y[0O4<,:<RKڊФ)*83+&'cp1_$r&p#
߷TFހґ3bOeo
>#iɬdg8lN>e1ˉo![2P8|}ިc(hHcU]չuC^(İ@L8:PjN0wVh@.~]BiГa|VѮV? ~1;R*^5(ϔJ8dvxT	=1k`0|=F{l"<f_ECn2ШIj"~PE "c}6(֨Wm<k,>(q|do</Úfo}rƻD*%'yq)XBlyæDVV ۼ27*٤QH;Mgn^[-B;@f&kC~LAqzzKp̤WwP;6d[bO~do#Ʒ	̷DvtǷAѾq6uo"9oV_MiοJg[䄬IL#{"jwFz	?AM2:nLU:'d<cl6;B醨n]гF,ICB	e*b (g<1h MSzԅ	BS-gWkV{[H"7L.i`jnhh/ca0D.߂GbUr;*Llg6Ru##"%k(`oE+APDK2 .YsZ
 0&t{_UtazV7hv%DDdv&ҏ_=C*)3:B wQ}jSKTgbr?޽6ІdEylvp~G5ڕజ=pZ!'P禮ķ
H>x=e/\r3w#ۮkkj9qҺ0CޔJ'FĲu@w &T\Aa~&)~$=}5pNIR4LM,d=pѬ:Ta Lðjn҄[a`P#S؅&= /M
쉬I<L6MK+XHERGnfxmFm.VH@1z7)V^PZR6~Hq>ף0K]g  -
JŻ_ys7Pd!"3 U?o٥كϳ * d:_ߪ3і9 >=|?W7WugqhOKS"1l'm'f.'uKG``o9"L)"p;)3oPֶUѫvft`"$8&t7{t;Qj%12GF賗ozͳ)9;NRWmF5uXaUaeM/wCnUs
F%L5
l_/ſa!/eF~&E!H#Cc+qma"͆խt؊skD4vrK4jxvKz)LŐo8VCt-$>(BE</ж&?ZDߴ~o.D|9kJaf5SPXrڈ~AFT)*:--aq-ۊL6UEb>ړ7D:(]ñn>YiEŽְW#fBJUĀ5Y^6xQ!CY1cU*!.^T[wlӀE@gJFTS~8,҇(ƪ\u6;rm}o#qxu>j){)rV`^)|W̯l!{yx5׿mRS-pp!QM+V@]lrZ8c"-7eԄHCb
q̪΂MAu5.H'I\K^ a.X(ZH/[I}?} asyGԷaٟmҗNBO6hr=婎*Eb/2a=cK[UX$U=Y4:O1D}@Y+q~kI\Ye'[(k]_/4VE^3mvh_U|V0vQLHf}Q8{RtNOEj7 ic#$ʯe,'>@S!. 2E\"rpb7;M9Sm@5^PZuKgN-$'=yEѝFw巸H#;D1𼖟{aV2H	wzE0~?AH=] vYA{龯,:ECc"z9Q܉T6^_Tc`/þU|:sUąa`n={		d-!jC<Go׻[F+c_u0"xvvDtuOD,~4)=|1y0N0V:ϊNtH4ؑƿMOULsZÍȝ05_Sȡ}$ľ.̭;d[d+ }^r.bTLs"7PH^Yz8VTϲ
mB^jm9yݒ
ZPR0۲³Q/&WoL!`3N';;s}1Yw´#\wbV<*,Jd-2ZobƮEF4Y>R]BzRuKS[U:b CHK|Kų9Q "\zQuyjJ=<EY_R\XxCvqy}
|~	Ss@`,wCyZT2A\}{:Q:0bKB)iDU:kֹ}#MZrVRiE3#zKD'J ".Y\1xXa&7?wZ",>MC(}j$k/$5#M(&œ$BpZ	-tUe5c=q
8qkqvO諟D8zE]vSܱ\=ʾO-rHۍ(*{$tԃveW]'D9!M k;<,/|Oz=67yèߓE.FQ&Ǧa/ڟX@P'WVב̾^cQV.$>TCۛxУ%Ս%pf7:F:LedS(VnSL{1i
l~ %
ZRKT+|>B\?I''@IT4TFs'Mʘ Eyw~)s
g8,zC>.% <ԍdݼ;U]dCyܩtNo:rJL-@`$'Fb/e26;ǐ7CxC[h,wwRsHg4%/xrH c;y`1"#I?.0?qd|nU^lP`bS/_]̛tsfR#'\fR FH
D;b1TXCo h%'Rf0:{By]*	>ͻYed<gHBeZ:wZWmjJѴc*-[՝<YVFQkIܙ<Esj4qxn˂3$U(:r_Mg)_)S$8:[
F** pAc["Quˀ^+[$)"هK	%|EǅKGr࿑H: ZPsԬ"Vhs82|ɢacܦ^v+́In6\B_pͬ)nYT_]d!rl	=[6c8Z0Tn	UtR_rwzTPWG&L#vk;ld1աtZ{~Qd{2CjnmŃ#/t1HPXY-|84NY7Y O.|։`H窍~W|'냣zk]yEi[NTBP9Tg5%pXـ@pEYfXy:.;4`傢-ˣ-f^Ï@MW$r>t0)轄/t;@)6ҩȐ}|M'o2=q[y=߉}<k+7A${JNJ$y.䲍>ή0HEv//^􄽊7F)Baqĵo8ô	YS-^XDIaaB%S6WAi8}!!OuǊx¹uV"˴chSX5CC|9xR}o3݁dGxyR0Rf4j(cTԳfmӫNTX3;#;02Be\mouMk2V64 >0F}lBsMV̓p27.wQ#a59S_ȱjMe/wmyj -@ee&*šlrxz}{rSa»f+C<\}D?*hШuZ'A~!Jŉlo'Gi$yp#ځc]oKɰOs.ɵJWP>յWsSrܔC9lbNhh3ҒϮv\F.`r%:{;dy@F}K"-CQI{!]u*!,ѩϚQs3:"8&g}؅yVsЗ,kiC?d29L aEzF2OQ8լC*z6 ;խ4{ʣu4sXiӯMmJ_9o8y-aH|ÙI$#-*SSBqg[q?8k3gCr%oUn7S62_j*vgkr a燊Zi@C#e8m6k2	%@NƩ=Z{
(Y;]S55Q-C%xDϖ䇋"_]-\UR0B[?lƔJOڷ49B`w'c
nba+ާ*?9:>s<̓uWtԗZpqFҒtUn1
q>YɈ؞:	yW71<Ξ8K@S%p97.mk<vg3=%:$-#9ʷA|EsO8G=a!]_WVD|-檎*+=imc' ,W&kNh,Xqg+oJPM>abd/fHU}:i}E;`;7]Uusw|ޣTgqUBR?q2\u
>M/Ny?Pg0g@wzվF[KQCi吊EgnY5aH
-`I8x99,[CY7l9OU';	Id`u:5 Dd<<j,3878ϗ@r)-a$%sADgչfX`C6<ҹIzg,~q&1A,J̡\45Q,Uj#׻~6]%E2EM13aw_G|Z`HFh!ʩXj&QjPZU7ʳV5+/b'JNq!RLq5%8BxbtDWP*"HWvP2uQ Qօo{zQo8* sn\i*KF1|2*aEMR4۞xbWHNYڶZXpP" +3RPR
Ob3$ OI85qubah/!(SM}M!Neu%T'^GN>kȶϷjOɭrHU#KǨq
5JQa]pMB!-dlD:+)ز:*3<;:I ÄIFn_ÚA(.(Rg3Q4HP3>HjM"7[o"2uT i(-93;(>P 9QQ SXOK@גѯej_lia??̞bpA>[H&C 9!kԑc	t{<Pa.%̊k%rK~Km!iin4
%:"'侴*0AX6FGg9p-:z6R9.U}b7eD#Hg
r.϶nBXh_aLJMXbđ,JKlSh|D:`7NgkG
3nH"	Ksz,9Dh2Bz+]݋:T_3UT\Fl/wAdi*X0ՓS3Tk!jɯoJgIK;nM.FO4mؠ2ɿ:E48;qk
-S:f{rzfߟK#8uZ1ax-ш־LU\2
^C'q7FmѨ@(z	au|BxK;Xtw,XҀ.'wTm0zׯA=]=`
8&X `N3c|4H=Roþ@\ˢ܇÷LW6VE[x"@)pH7g<pqf8&-bcEG"R::aH.jR6_Bͩ/Z{>pC`l_UP=ӎ~Ԣ+2YڢuѨC2e-U#n]~UdHEG}0K VAydǵpX1koV% Vxo*sH]%'TC q&[2"@Rpq):}]}µϕh#0>ܱTOqO6O9%~F7T~0S8̱4/%~6ÓNw,8X<x<ŉF4?yiNj>ARkObL3/lPԏoUCv'k]6gn51󝈝|dڵeC/k6G!v@/JM:L}ӾYƿCƋZz%<=}2
=frU3c]t3;-l|޽C%ZLkzdO0V09܂P4|]$;JU,jO4[xoצ6(GõGK)$=ɄlG`w7r=]lThULB|810pT#Ĳgk^o2U>aKA0ؤҕ3|*;@q3gM2ȹnt+/EɅZ)H'Cny{p|1D10L>U2?~F1tލM&vDTYKM	C?ajkJyl<]BZ;5*)HڄsVup3V7kX%#dR柚]߷wݖANST1w{]նe݋b'28)t~q?'F()\>.)% >pF
GvQ>G]Ii ՟֣OW<
7})'?~Q;㪋2	_Dx"ť߁rŢy-K !kgtoP+`ʙ]o0	tPJ0u^;;
sZ+,Zm,DήCＨ>/ݷl:aW)tg0j={l7vw)iZfKPH\wlLGv`QH܃5{c2CdjZ{w(0&B<9pQz=wJm1	,L<G;?ځ0#f5*JQVu&l0X^̓NtCmSҾ\)KS
s&rEr*umXC/&f7J*ǵ2UUm^b@7GTymy.GosYŬ^v]ﾲ~Ӄ߮~e<文]RdXQ|,jPf$cD|.I9t~LY=TId@Ꭱ'E]12Nh|&-ybT9=|-c#|#C(۲nG>IGy^IJjsgW)Έi2hI N?c7洝m ;pSƑA(v$la@ꓟ>Ҷz'An=\Xт+H(Θ532a-p޺W}y(`%5?uHF&\Eh0WX	cMWE9>NmTTQcuQS!z՜¦]ᇕUx+`ԭ-j-wBnr
(-E=NN17 MاCEnE8ڇn?Ar+G`Ԩs<% ̩Y!kx -shދi),$:z:B,~J5VVj
],;lJQd++rcoE
":=U<-\T'~QIb".I:͇։vX#pU>DN$pD^=
YOe3Ev+.ÿ̻,7CRٿva GJM*~b~*R@Vn*O+ᰓ#}N-7Qgy%ނ<kvPބWZ&Y1 uQN/܃obMX\t\~ǰy-sO{]3F⎩|imڦNE/ܨT4+ʧ9ԟ_?h`/X"}P,ۤ1݄'KQ; D=FO-H\$u whKD+33+"UG#\{9qQZ㰾
AԼwF7*aXfYa>T];+.*cvpQ'¨&fF	?F7iq,_+:ZۈJlǖYfSbW7yaX8MZʋ';9BNB|LZ*g&hpzSM,F-^+
c̑0xW}?dܺ*QiEM!x6bW|i*vu
7/Y0(<{.y$Վ{T;de H>fa^>əܙ{̮`W?EH1o6UT[κY-^֪W.#¥ [}nR­w7bGFI;M:x si{궃g6 "X1(\^7cW]8b}@fPZ'FyވL_FRj%RR-mw4[8yW"(oĈrk"umYr^}iݍTHWf+Ij'h;C,7A1,zluBOLu£al)ܸrMPL{znMsU!c}N#/.z_.|ELׇ)}-u,+MOw_	Qo2$vg;,p&Hf|&mv(vy*WK*uaE.>[+{>	f)KlF7	'?yj;ɽ%IvHl=%&paދ/)E"&YLhgxz7*+%C,ZC@Fid #A$Z=M*@c@.R&Ϣ(݈:$⾊*SN6r lwm((ޯ6nt1N]ƶaϘh:VU- u,0atFHV[Asg^EԶĿWi4
˛F^޶Л8y$~?NxN}{;fw wwᑖý=yWKYxt;-@0Yf\+>{r`<qkFKՖ b0j5'	xLrB+_~vlb(Z_21%2g玁_PywhdFlLL<%ZxABB:" C̈_T_WLlaA*wDV1R-!)jQuVkhƒWё
VܠknEe=KdYw'v?ktm&.e?a]}EN|L<i+DΡc߶8J~kcv"il$/7b]`OV$H۠Yp>FcU)u<t(kEr,ZQI(x9"EoW8𕸇[tfCH31%@YwWY>]®mr)]j0owX%좏!{yBj`iA Raǘ	X(nzY#& XWdœ^ڂV z.
%~N)*@3<{mQ[0;Z"G%2BClJNȵ-T|# O@Et8V'*:>$K:	}ۨNp3h&"&$r@VpQNy|i&UzT6QgJ9M	78]?6h-8	;vArmbil#R_|&Oݳs9r_$;qٮCzKj[I-".}YEc]P+smOZ&T^Xf*9~&;ݫlΒKMYgʿ:"XfӬ[GfW>`4?FnwЎL>>\?Q$?K<f}++oo$S!;0w_H;אY#,Petco|r7(?i H OOlȳT91eU=V":a{h	)|:taEa4Gꏹ8PGCߜΑ\e)FȂp4"-ܯ/qoH'k&*3=Hi?ĭFZ҇RAuRF#F:Q yD9/|;suIx𹱱no}@2Wn\^i:Y9	"Y`tFd&4HSIqѩs}ACl>ۍ+.M[RaLt+W(/)zCYfJKhWUm'h!i"4|!mEoA7V4/97Sq`F8<3`#	?^[^׌6oll=$,y?Uu`ɁZ`No}k̈́sPr[3ŕqB|P"?277!W;T|W%N;qPx`! e,IPO`ʵ0OlN]8P4be4ɿL嫄z!Hd?'sx)Z!qGw-3y?t,ێWD9g͌Z<_MY0f{הd7QU*l$~XL2:0e(VJ2<?~Zks4VAPK&cg{avk٥1~H>:#E~a%:]h |%b%<(a靖"Iz Ϛsd팺}{H^*kE%wiv$۰)9%Gw_>O}y]y	R ;B\GuL5
p^s$뚕\*nf]U؈c?elu$^12ӌ}u3yffǿz@5%\](7RpCw?'E$#iwagCr~^ܖfB[u"ğVkdxҴuE{4BZ;SXҝLԐ"E1=rOF+ce̀5I^<O6f v\g,S7HZn+&WA/z]!mL碌<oQl?47P;]l;DO'sJ2|I~')pVi>I|l_R,oPS݇$pmf75iMto%]𶹷(x3ƧЇHׂ&T-Qʞؖ\=Dz(MMR@޿A<d(x%'ຫw؃jFxd-O$%3L*0 5g9n ,1Q4hFRn:]3羱o,\4Jפ0|@u`7ϏfjɊ1p\Zq7dn)T9{X@-z6f6_ӎ.5[$]9;denf&P>Ҝ8J%fe8~\o}]ްn0JjiKKNHY̴N9$\娷}"1kC-1CBwc,vkc^rݧјoWXײoU">gwpEPgl#4x)!Cs*-PيQqi+ݗGGgB%+;]n))ME;FSy/C`txҙ}alx*LyZHZ|'zmGɯV6<"NhUTl_H4~c ;DGMcZ|tyz\T7358UG_oD2f[9a?P(W
eHL㚙1[S5 }YAX|\d̆j[~xYS*Q_E%Wz& _!D룲|f >0dB.zNЖak!WMeLJc{B3	vCσ]Q397cXxH~M			C.G_Ȉ/	h:>ZԵ&v\J*4M+I6PrS6'膀&mRJ@?ʨr<h)1;xQ^<(ll̋p iБ:uYى3z[#po4Ʉ ˆ&$mÌJiVyz⥫&Ǌ 9ٙZ;AQvۈY4x÷:f'bأd4+IcYjLöK_פ6h RZ+,'$onHs$*=j%-~DN0ԃRJGtUޙemnI]!xLCTFxʶ#O3B0xA8ʐ-c0d$	{[*v;$RE5iS*k@̱3Q1Lpe/c+wZ]T2/FbxՁA}WݼZB1A5J{b:Cu94:5\EEIc@-a;dsYֳcc,|y5Dl r}-ur]+XJseN"zMĳPl8t~/fECeJ
,%6hUE`{{KvIQ[uK:BvKBͫc ᦳ/^9zbAΔC?v5GL`qeT]VlG=ԀIǅTԫ-51ϛؕ0WHA|^uq*EJo}f&GdGa!16y~I%T b|n˰v+yi=DM{jLk}є|6mkY ']&g|aX,12\wh-~h9}~xm(:,ju󅘓i2nꬌ4_aqH4/ I:kItH8TX3	~M,(S/c:|PkM:Rbm># cUnA;
ho@Z0T:_OM.@JpEW:}̎mfD+A#ѹE㲍΀.РmzIn,k	pj\9@~  ; Y~J0yT*H :D/*6msPOe;:Dv{d6X|y&aF~p[_8ONXDTg<^ܚ= 	XQAGc}d%bum*Co&&J4É*(;>xLzpļk.dQjX4Kv4liB>ӆsP#JGDm')d욆{Dخ&u5/eDǥCek)%6ŘEVVO M/ӌh.H,qaE"\AGE!~i#BefU:@Uug8`e~'cR1Onը>.)Y,}vp)IKj/H*H)m@@mprgxGi {㧧1MB@E/N8DzߝLq	\]%˟r1VsӇ=:VUP	B2r\GHUMa3sa׏
v5o?kacn8<ylS74J&o:iuzRnԀSZT+{vG,n9UJqV0֊aRAapӑ"b+J_ SQD$U][$GM1`UpzgAV#T,JCe^úR%1_W(Id϶RT\zY\F`mH9Qxq5uQ3P{A~B38q*a]CI[+:sKh2TSy?Ze	MGB\P
j?&L,vnD#&G75:jme&oTׄw/O6aw0qs3n@D^lh$HF\X?:|_OrFQ6Xhv;9rdx( 4SӈF+iQTMԏ'ygjz"]% $/]O;;OOLΌL&o+mR/ĉIDxeK|F_G kO=#Q^N34z(XM{,Bdhpm.On
QdTrpN8|jNoEWQGݵJeZjXh&
JvkDDAc$ˁ棾0Hיթ3re[M爺&YVo.+^*tV>X78esBZvA~2`\ƸP	gX҄zICoXo0=( ъCL;ZUk锶uad
[B T60+8b/vʦ$bhDt0Mz_hߏq S:u\3q,̹?;xO PWd󊅉qM=
1=Ϣz\!3
B>{ZUawuWVc-6P!Sg's0pAFfdln2E[c!}8jzy0&4Xʃq;gKDC*΀{Ƥ	0yʒ%oy%Ti	HB0|t?ⰂIꏵgW	E\t|w?z{bB՛O׃R}W[(HM酲9czUPnƒґNOG;OYL4%GaEngHpǑoI^vgA3)&#bc\   ")g    YZ  7zXZ  ִF !   t/] ˇf{3(1v%f M*	mj)p80*i	NY]QF7&!'803T+u7.ƳSCǽŪQ7U^$G]ך0dQ&[k;͌Sɩt׌GbC	z O36.}(pϤ(E7O22s f{uF`)Z8fDFǬ:%w9%zyc/ZK^-0ie#Q	H@XcS`pC(q"T>1Pؠ;.ngП˰\/#u	1ޢ ב$FheIJK||zTnW_{hJ+Q襦qz;0!@ѥș+Z.DHɬEEIi&)_(in?iւmKд,*5EވoWYT%	btJKDiB<Hm3CZ!᡿Еz;f$뱑+?:>w5>9=w7C5ۗF F,YR7rpWCr&sG0E.E/P `;Tܤ B1@YC^W|5 OxұM.Q],I1	%1p{g't#ƙ: Rθ
c88؊j*_œ(Yq)VH"j߭8S}Ʀg-ЂQ4`1MaW0l&*qemb  m~w'K7x||$`Q{qsl{Cw8v.pS~hJe
Xߠ?*Y|vE.~?h!۞lXH*T$b嚧 fʞ4&TG˵SnUgi%ĕk퍍M{q0l==Sj$QlH@+(@ X?^ǟE{.x>T(:YX˜bb Ô?fn1a"h.JYWo,r/(2%?uCטPA d0|>sF%%@E*tNTk.)#
ےּK12̧DٮlqNmp	xFӸ[ɉwL:=IպDٽmϛ܊8$
5qou6	sBGLY*7a\(ʟ[b{#? |~\oSPNr=!I;'4X1/d q	
ք>>ouTG*2CAS!)#<G홋
zU2u8u9ZznE3̝ݢi..r#B3tk*4w 4Ev՛:13\tt^2ys!t_x7RB.EJ7(KD$V #!/؉f	ZOHȊK2Zt߄a;$sAx^Z]o$aS~Uի6WǇT\3nkl$M/`<;rD%+ykW`K-ڔc,Q_P&8%?[9C!'ŜBìxՀk&Z.dU
nnT Zѣ47; É푅hG^+uvΚf	*+GݴP4lҌG7r^.(Ηp5<@bEC	܅d"Uϗݯ;[HaD%J"?ZO1^˨b`PD/#:!~#e)&cp_/aɒ\H;ѯloޏ.=&=;nxI	oP0Sl^5Ks'aGJQި&"5*x4oַۻUP32=^E#i4Z=l'+ҷ	uX]CG ΄ FeU ]Dwsʵ cOFzp<k*Ax2B2%
TXq7VJGp4ˑۣ
paõbK	tFCl^Wwclyz;"X<}OzXPr4De
p|nbTsEʡU˼aFf9flv"̾6[/KH Tq+?D[T G,7CY&2R8/CSFܰƹP5pt,훿9JhJgq54Ujin|f}/yPa0G=vhbuP.2nYN!S=tuh#;ۤ|Mv%wE3{2IDSA]y's4-Q&5p&Nh9lUI,Yh8 5<~9>J_^=Tw4G; Zf6;ԯ+Fn_(_ސ<AUp+ޖͫ.}ߕN梮G`{:s-N/cZϽD,3WtI=]jGl.[zJPl6ߜ<BB'GNTgӱ
<sAj/|~	-鵗ez_AYKY_؜x&v=túy+->,	$QejmQ%/]"		kn4'w共EԽ-#7TDrn̄N{4'F\dQ	Sm34ddsXq_ٔl'aŁ&]A#w	TyFOar-7z_9p&o֭A[Ia8/Uti`&]hM;nM"#(GPƏ/GtD:p{o7pqk hkOEb]|va"eyz$[e%(KyR~GCEj;%-8Lᭌͭ<LqiKIPF3Vm4ukfX7qdєlx|:-!~j'acǟM$G&0nj&i`	@?'mqHjje:(YO#&:oT`K/=bso*.px!م~s&qk2}9jş#I=W Ə~ZDG!K6dJ7omX;ie-+ŹJWtfL(HG0kb	L5vPef]}/޳2TAUCXTWimWuq$i&za#-ǠйhL"`MzX~^	ҎXk+n䷒T    %! ҩ g:ݱg    YZ  Z      ZZTR

SMP4      S4z  xKkz~wc1Z{C9T쪲-q\8"%$XA҉@ew
BBh ::HHH)HUךs1{xnәX}HsLy2o?}o~p/?!~ dDo[/?'?󷟿~~}~r{~9Z2˯@
QCCJS0w%%_vܯ'1UPj<~|:tEXp ޺2!1h%b2ANW{Đuێ֑znaq}´sZUL1{e<M{}L˯k}/ce-qc^Oڽ5z\=y|yzøOQo˼߽cs/ځmk8d߇Hy]St{$#&x<0߅4D+fSхVJv2lz|RyT8MvcҘ_cyk|m+iukJD-W<vk8)(,B=ˀ㭗e`o[Gإ6<xx0h:bz>ϩ<n+
dqφzOvm@íer}m|߃zǗ;u<Ov4s{و^iy0԰RNmP|*,tp8ϫiZ:m糝po}ק+v<~y
pX;Ve%[;xPSv|mDK|yq2[|=n<	ahx4\~޶x9Y=EH|[A>ǉ~߶Cʩ&[/`^|@Ж"7\N8^_a5b}je0Mco!`߁׵a8Q<˷pߡ<Za -?ze:i[Is3Sxe{o<>F[~"xzyp?0Tņa<B"{<__<])a#t?GGNi*m5G-'x;[kJ1f@^zWzf//oe:іc7Ĳ~McLɖ߃zX%8a9C1c|C8 6S>m_iZq:M@mS~k__m΃e).`}J0"zl/c9[P1v\9E-G,iL}ِP;pQi;ͧ|o0eNsr{ǔ2mZ7CB}%O5{O1]/Vo2-aSC@'z9{[-10mTc{ގ|Vkvkif6v4>\cCx<5SV/5F&/sS=!-Dk}m6Y4sck6z_.zko:[Yl}@}}SD!mGS]n+4M`A
ԭ9nk%d5jMiuff
{G~Hϟ?o+	;r{|z9z}8_+huv[	-?xf_<>^:oۮ1h7pm\B1[~{pal0
	y;>ѹ.9(^m-Wgz_K	K/{:Mi뤷xΓ__uuaprzqte;<-gjaZyl5/1nu=zzJSAV<YQ֑1a]Hl]ߢ3;Ju?\}}s1׬0̗I1G3dkGA:]2³3,?tCת3S.dChu얮JYOViG},?z{6/o>`{jT^ꑐ9-?{۝<w=9]/䭽asq?nCP^ÀS<4dӔٺ必F^dXM}rDCʪGajC7ml48ChjLWL47;th8S9ގ)M-Gz1gX"b
[ [E[zffq1^&c/m=rnp^7T0\8ڽER!بm+PŚƜJC-DcAD ~|<b̼4wݏ:2d~b{z/6kL=j,,ѽp'vD<MCjclH]^ن}6*f'J˜bіpǮ=!BaSHuiC#'WP=(y*0GYԼZ
?T)Zlp<ԝǭ55z;bE-VDNR\>ABﭔn(Zrw%ArAMh[Q=&- W7J)fl+p9V%a:Tۄ 뇪i${;1JmCPF|./IiHpW`̖ХGpC|uy;8-:`2S ?:{IEKB mxa+;?n^'3o"	i)t/8#AADRv2?ż"R@'=BQY kY<ۑB@@0-N+M}oi\Rkѷ9z\CǰOSdU.wn;͋[/%L9q((jq4	<hm;P`7!u7-cw+,FYbνnV np
rOaGQZB?=y9)3߄!^=9@8t*qܛ(nf,irgm5j<C#iq<"-p^ jyPpWֽǘP;rV
A.|C
16Wz9m="s5z8XG[YK̅Z+bѦ^=N扭Nc:ub/I>$BMoǶqڗC&} ',u{	S8'P}x>q#	ET0䡺W/ pW!b%j3u䱛	 &Qat	hPr>I$ - Z'E>DY!	H\>B hI!";@(P !"
F%N餓BD:	_"蠓D:A
 -tHJӜ&!R ('HP)Bd	  .  @4%:D @A t:	 	Id&!	"E'@!@'2\@:ˌ]"[e@@D!"dsdr
@ E%BPp."DPNLt6-	D"%Z'}ɠ RA	)H%AI8%d hA		"ds@	HApNsIN
!3 !QDL\(.B$ 'BtNC9PK .-"	):A"ph $:		DA4p	
"TPD@H' K ,H K%J Ht2 @)$ $ P(' @"@:(PYYAt "%I(R%йd	S   '᠓)D$B 
P -ADZ2(8@ $	%N
$B(8	M/N@,Q ֍r8N@%A2)@) 	DD ('HQ)/Z(8J R0%."t Q\3t C4%I@` !RA) tet tt D\"::muЗ: G NJA
H8AJ  PD&KHi)@  $В!tRH'H] /:MZDJv@':A
t
t !n @(!.t."NIt &@t&-D '@' ]R(H N:H&	APPhN:EA:@$PN@A 7KDPAa(IH (l @ E	!B tR2	tЗ?vsV@+7sۮ#N8
C>`-Ȏ`|INDʁNB K}<[j^r	 !ts7тƞCZQ15+{+k4ɷcp2˩ղd˚^r	{0iA	i/̖ડhșQۀoޑ)M{)lPiJb14L 'p:MFD[S{<Ql۶t9y
1=NsNcsі=rIͷ/ 'P/^#?ۣ~꺽1O!N'ua~NGOc[^~%~=3ۗ4"[Ys[)Gh!۩
he<egP;8Bhp ^|ӽֽt}\K}/@{kg^4ǡŰ!M>>!z/[(pT7/<daUmkf?e>]8)Ϸ8ɖw_ξ>n2אay׭hƺֳ"[1+m/%/1)Go4ˮ> ;Oq<e"r!ۑ&G^%c8lAsk}4n)~w>u4'CrHy0auoy MùHJqu~l
is!j_rRؾk8l󌾿mէ0^sl7<۱tzi;ُ|kk	>S6֧s:Ǘln'7m/JkJQ1e<B:t*ލ
O42a(&||>%oqst{;c-Qemaz[94_?UOs
r.C=ÐCDK|N9ws>_۶뇧Yz.3zxQޢChQnʗOéϏO_|~)@5Dz4y-&=Ӗ_@	qkOOeG}?;iD-՘Oz۷:})[>u㾕#҈m=^6xB~y%j!G1/9ag-5ڎh铅_e_屭-,Bea>[mim_Wa8,,zpz{<\}{?ח)J̧$܎{q^vmy"v\><]ﷶzνWCɹ"z4r|==ٳ׵tR_Qoo?<?c)pUMi<GoQ,slvʣt~IVncSJ<Rarke8l3}elxq{tځ۫|zqV-9~}KSI&Vz!/Q^i@-'&O {LÐ±{t2GX~J;u/qcɖ37axtbOu?v!Ԃ-ߠm<]f4IнvqL{) o[QF8r+arѕ>KbZHhj[\߃iG1H^i8'!ryL13juph}5]cf?D{A9i
sυN͗v?P-mx.9՟ՆlkENP"-}|X׭6M_=[y>ű۫<#kN?Mq,}]	}dj	HʗZ=o9cK}wxU;}xҮ/=e߯zaC@-74[Lh1,9=xzm1-?zF^0Ng&:Z?Ǒm8]cG8 ɖ߀Z=`<LhіoV7A޶uÔB5c	ekGL8[}l!Rdˏ୬ɷ@Nc
Aіcϟ)|uJh߄N[fjd8gϗPn[yΰ}qo?ϗ߅o97շ|Qs^/|x>}y+}z![>Ӹz8V\><db|^ۊcԗ|/Orm83)Gm9Ad-X:֧4P?th*[,9rPq0<]r=4%2CGW)^r|8n_nHs5k-xm_ۊӇqi_Z>{>s8K}96קoCC{l2T<f/qxt&sScs7!4˗vw,;4SE[~yq/é"lv/uzIg-,'0ϱUu-}<c1]ўϹݘB2DG׭$goj:cPwZu<VLi1,
yb'uopJ67[ je2[9%kp`ژz
A>zp[~5Tz˸0?ŜV8`,Q˷8'kЧy:1}K9]=r>AoA9TB%G)DYX~(Oa9d\ƶ7ƬxƜE[~G5Nu}_[	ӔZ{sZTPl8]m\˫k6IILàP9$-gײFq}kPn\mﱏS61elʺVSHI\ j0;qx{yN/-4_]А.=鄼7<<)Rcpz	[8Z;VH9(Ű/ۮ mVO!r` Lpn!:x/=!R\fȽV,vzf!XLKVӜzt	n!=m{;FZѸg&ס8[%L)z2&;zz8Z=2{p.wUs_]9c5x+[Pf	yjfIqy/J+ItM*,Sַ̕AcHaa||2,,K)`'9Z(bQ!-	ňZnh!Lו%m5c.l[P'b/>Ř|ý-p~lCc@'(1FİD[&km6JAFgpA0"m(y
K2 Ժa
L)Z_܅^VZ!GjT00Γ^DEARoz2}dh$͖^ahc2AT;ui*/z*N.Ipo{LBޠ`/Cbo%OhefAאC=dF+8yH#Jk<$ZrQZg#ZF
f(1- E..݋uŔ48[A?]b)aYI͜ZCYj0=)=hahC[#Pq~bn9Z%FאਡTM:G>#ڎu@p8ܽ5xd%B.PC~$y:ł1aoec2ZGJlR!{]13Qlv) h!7/]VR!M:RbJoZEL\!=zL5['Ks9Z;"SNH4Z2")Y,*{Q `A"23R3}.hoB.,PU~CF{4űx2nm/u42h 9$qhvA\`!fݎX`f߀+R֏vLS=[m|E
ozGi0 p}0Rr{<9[VjDsoV}.spFl\~p [sN!yX(tW+o2k'::c4K9uS3	r0tlE
ت+|0R)]rێx,4ށS=_S͝Zm!4-63Νݎ`\y;l3Me$L%( tV〹?RCH5)q(^puтzm8L;BAv?AM`n:vY,͙9T7fN @3Si7ne]]0Qr8 
Jw	" %cuF7!+m>65&Ѻ ȉXP8*RUV8	- Er8(iN.E"EH:`DH  89)З:D-	t@"D!
@M %	1A2 ;D%t J)Gp*++(7qpA D:)7  (!9MAJ H\1  		RtR !$%A P@'EIAI"@	

 " DqI$R2p)Ap&P!@C CZ2DArA$#$.	t@P7&I	ZD:AＺfkz}sεVծHV6޻1ƻFl@XB	!!! A@6"2B)!	? ]֚=1[ nJA!RX7t`@'TMTI 
^D
D:2^"D*3(u&
0ɍ`9+@J@'Ht*	" 	%N	ts2B "@'`I(r@'eM ):SB
$ p 蠃NAAI	t `JDΒ{:!A@t09Q"E9`9dtIb@'XDJJeH%p`. t "ᤃI ;AN,AJD:):,"nF	 D	@ 77	D
! D9)@#D@A^ J"  I UVn * X/BP@TpȂC'D$	tPNDP%@(8Kd%J!HH%CU,"E8)    $.4'@@'tʚn tLDIt	z	 9('P\P$"  &:D)De%A/*N3:$J $	&*+@9d&[SɐA/ N:	B0BNs@)@	P"`ɠ.@'dt@H!"H蠃^"d%r rNA9A:	 : (Ad(Aa )PpR"@'H@/	" Ig`F	DB`(H)N:I J y ן/! 4u	*$H݅&sU82, Z!@0ku<0m?؆cJsM-ICDٔ6A`=Ƙc7+/(QLsRz&3K1@~FalGmi҉-N%0 )	Z[y.ŢtgM3#R0+#!um<k0yMaܵa yܟiJmC=b!z?5'4^/͆[venK j?hPo3Nvn6bP~:\[ǡQ'7bKq;*>~Qo_OӇem=)E`s=Cn2_@uoch!?՘~?|Xtn]qS^yvna!s]:OC5,v*qB-+TVimnvqS/jq=;>S?4QT6o?0͑_C-^9	5ZyN<v旷ˬ㧟u\^oS.s>5yVC_Uo4 э5㘒OyL/Ln{y]Xg_߰ǟeÜu?Ǿnަq[:u~	϶s=p֯wS=Cn:yjv{>{ٷطOsXP~G!/
o/-xV1׹~\rok,P.k8͇oǌ}|͇nyYBNKXԱ}qzӗ/iYС-GKigKg/K<Y8mZz%͆^]e]"379Uq0_c4'+z}:z;|?]>|
>??߷y\[-)&ر?}ߟ_52d~k߽~-A8ݎ9_` 0Lz6^>Mgxd{HGm~{xϣ-ʿ!~Xxޠe\߄	=0\U는zOx,} GLLg[0Wx[%zSo}pt߱,1z6\e55mz{_嗜+.a<\?daN*j{)]|~}>!F+-CnGJSɺ ab8oO\ͧ[_>>)C۹!'zO:0~]/)oYB:x}}{_?hb(?gou_||_ӐoϽe4]|{ogKӜ!Xyo).oS=?vk!ԏ.]ڽnk"ZsZ?m0Ϩ=z?>Lge֌ԈmA_>n˅y~m5k|%ŁDP#:Ŷm34fG/8ܣ߂M-s4;}(_Yvǵ:^ޓ+Ip4Mq TwW.!mm{CpF+C~7ǆ̣^׵=49䞠~>6e1N5z=QZDb_tE9 PDePǹG6#ʽez-f,qp؟ph嗐Nwϯ6k8 8P?Z6]?~>O\&+6s	ÄڹU%L?ƨpYs;jnu߆6qt87a
V w4__϶"}@Tx].y2@u,Cm뙦1[D(=+&MYvVt	#jw!pDtƺOK
k}~uz4| %Lg!gTk&,mۺK]}sP90&z;kneDpQӖ`BG߮zɣY#OtƌhGzyyf{nn6Ѽ Gvywў;H}4}Z<tPy88u=7Y8yo%́ͬ7˼߾~Ӹl/!?Ñ\8!G$+5㈗5:\Fߞ|s4kV?[Äso1}v\o.ihiZ}=P9ל[[48ʯ!^j4퀱׵-M:8%+jxS`s3Xv]f=/CQT̯q,ayf{{qZE+#0]q>_^~c[>}x7/ȹ7P#ΗEz?*x	ukiC1(Z%ۣacix;Wi=y+p"ė|1r1uĺoXwg1w~xi6>Cac*1h@r?| ࣒z?8Y|Laאz;:a$x:9Bsܢ}iPرR!YY qGoKS(Ri:oǜfpZk=Z[x]kk}qΣ9߂Çԛ6">,̞Bp8^.9\;Ô\v10C sMcA,3}-Ǳ]@	 ru;w1%^4{{%N=0+t;1c(gaH	2]6Ǵ\2~r	r!=~l[90	r+9-×c0qyu%{4-a8ھ+Ɇ<߇:Ola?PJ z?M1"ɫtlC?)iFT0?y+9.Us8̗)Gˤ6]'c2oQX~RwD`1#40L8T;-D3+bRG{
sٹ,27{kR
",0f[zbu^8҂Ӭ|2U=#EDˡg{)keoigc:p}M-5hǍni MDЫqr-\l-d,6#CI:mI֛BOV>BmKԐҢjշÔjC,`)ǹfYp-Ő1X(0gryö;ǣccs!zDGou0DZr{}X.sk
!2zg'Y\ug[mg籷󘎎P] Y2@m)o1ڳ[pKiicU͍H)R; kV	q8*+cXB[BYݛfa\wKhj(irhyǐE,tVw0ǁm )X vTh;bcf	AL̨Dp;J(uϡy ΀K,!ku3#Wt}R3Bِc>B;B~:BAR[g6kmTG%r
0c'pi \eqnRMfIA{,*-??sHW^ KCwo&rT"T
_Н1.,+]Z`Q$R,	!4tvĦiQ𜆔@Ԭf埂Dge0x"tgR<8@g;_-ťtLC ɥGdxZ V$A܅la\r@.
ѥsNysR#-rF̂ꃈJ9X=g, KCruEf?/11зSG-YhVFZk D##pvFB~$]ICRVJxu{ T"H. !XW)9Co[>EhC I,YFY_w,vRɇuVH ],YCﵞsTWG݌߃( D˂AHrm:.M 	_ATtC'(:fH	 AK "T8%49	,#pP@&3uIMDtin4IA    }H  @8 QNcl5P" @"TGX&Q@'U"d7r Dl%ݺJ2Ce ) \@7 X":AJ:)$$@ DK%K  7%sVP  @0`t	sP"*s.B%A('4I (Hʄp!AP$BAP0	0I'dPL D'dH D)(S	!:M$dID	8	rBa @C"tR"@	t t!!0QtVdA@H/t A "*	b2%@	AN
"!@$I@HP p#E] !8)[_
ai)Dtg 7$9
@vrT 'AHt  
+ĒABfnE E 	b% @4' $JL @rR >7d@"(I(:%N:E49)ARA
`'$ NHA&A' E/B`NN
2)2tPmDt"H82DItMn! P  :	NJa @   $:AJ 
N "!NN AP2H	RI* X"DJ)H  772JDP"0 IrJt@eT!T!:('epQ2$DPDC JHA ARlJ" : t *"d Ht $DJL@N,.ӜtR  ` 
$ 
JJ   I R AJ!"H8) NPA $B @DJDsR!@	t@ R   :@D@D2^$2@
@*			) t"@	"d  R `AHg)	SK%JP" (8AAh"!QM,brGC?mMHBb	1n$ `jmLCa	;Y8.1ؙfE,`vddwm:&02,ߣ+f*QmS27uq0'k+!@}_#1gd埅zm˔^^	~u8͖nI]s@+!|"r0}?黏s^|cƮZ߄3Z)qyQV!oj㲼{׼0뺧esuA-z:?˯Kt]59oHoC:{&ls?²|HiofiN3"ﵧc}~=Y@sC1͓j1Xu bx3zOShoBv{?0ewZȗ0+DէbLL^wMMi +Hg6x=Y!)^gnVq#za]xbrjag>ctpFQqQ=Y'}Hknx	1d?cZmw1Zz}>-?;>!?
=otczYRLgkmka|vѮ?{]<t	}{?,>]>^s:A
߀z]>G=7jL1	mk5K{:Wu~l܈)&:we8%Z}8S¾=_ޮW?vڲL@Wp:ₜeh_sǘFѬ|^|Cvzɑ_@~HSa}s%BZrX {algJၘ|>r׫~;[%'zJ'辝._&i:4[ݻ3bK4[hMLRw0-KH ^3_<l4
^Wpy=jmڴ,r
6E	b)q_Ɣ_ATχn6/Ǿˇ+z۝}}P~52rkw{8{Ѿch
NcD0uˎV8O󶺅qR.s݄FY(n}XdvttCM8yts?֔
!Y?!?}|qbLꇔ>pq׵g^ <lex"?UqƚὮ\ϚØsg(^h܁ia)_J9#|y:k=/h8?ܳg뮈9q1SOtx~nU3CJiA<{L7@2t?8V3CʿяgOyYڹ}'BViHr}y˟l>||=~C88=܏mCe=B_b}8|YP~]ۜr*Z1s4أ Q./S;[ɈP~%ç%
ti!~c_T9AqgCɬ:E;k̡G+A2}v~zqțʿ	dG?\uBf7]=P?11y[YHUiZ7zq\c0@a+*CD+HVb^:Çw%M{o)/X)	-=bh%ΙFcW;}b5Z%ގ3麄qC^^s@KV6%X֭en30<j\r_sC[<.KU?)e=)nf	\`qQQ3.sZh߂){vL)~	)!/4ُc=ly]02ʧY5vVS>μo1վW `qѱ3C`eu'K<z-\Siy=e['ۡi"s=)}p2~1J\m!kju_Cqz^-0)k8Y.'~0Ř`OB,-fnK$C`c8Gڻ<z2{=ɺꔐ^w;cph+}}B`y9Ii^mGd PHj{GZGS$z?xZn~ i
_#r@2g0ܷͦZ
֎nXFۘeʾ\tVCwo;+<aŶ)Mtg?&&1Lptcc=l8۾Mo9itccV~[=0Zm54"̬|󐀳OSЄ؃߇I4ї6A,uP9 ng[StGPP&B4O;O4tx9q5o	b/Av)1-YcHv0Łו9!XNgz>0~kJdShfC@oK6ZLB<)Oi$L mS[pʿͮdUF9{3,#4EO C/߀C *ވs^ctGz}.98:k=,j5IJqs]}y\W:+Yxn1QU>ݭkjd9|o|]g^m;Izj*Zg[t_Wj!߮o㹭_ַ8grqj^? Yܗ묕m]WzPu>}Ƕlf'}^Og:,ir\+dm3cl9ϟ}K$Sm2?<g]~=>׺3o;v~mm^?|UO9΅^t7y5{ry_z֙ã}-丷{s~.7Wvm۪ݤ<z_xQXk;ljqzgk;̺n:|u?ZSz-z۶Oo}}5_ou|77'g]=^:꒨$7n޽^5礖z:~KX=ʶ?^5?j&A&I/s^2Uu}ͫV'ӤJs>מױqoۓg˄VEzz˚Vz$6+nk~ҏ{YUi:Xu]vff~<n}ǲ:ۮuYWGEbZ\uz[k7~~[~8V9_}2wkucz=3W=_Z[fu[y}_oyeq%i:󣼿-̏czco?iB2ϓy:vkZקǔ*4OHYv{n<9Xu׏zʫx-$N}v:ߗ~?;˵q3i0c<nyʚ\/R0ӳ^0^s=c=uYerVqvxvƶƯ3;HWs,To\SB+!`[	:z?"	$@\mm ׽=ןc5Bf׺:cdlDTn$2~A7l	L+;b[4[ƯH*[`bZ
#Tb&H; -Ì,Irz< PDјPqtT5-J
Iq::$ubENM=1bh=VBƯ	
c%d#mUӆC2vl%MF!"Ĕji 18vP'(-@k01!	[{lVHG[C5c'F$5~cŮ@
+]"ڒ;ecck`k "HXlmmmqJkјI&86l-[&bk$6L0LIOD3~!@;e# @+lll "n1uTNDF _xǊ	1YW5M*_؈lL [D4c' b{Tci&"`;vʌwLpl`;V"""!ٱWjfD;l"J`k07Lh0-`kt0 qlVZD4DR I0!)Ml"	vj7qD4DD[&8Va9VLR	Jh ڎ;&贐dS@[c=X	jb9Pb{܉$X6iJ0-,T=vlm`M* `*c`%cń[+mm`vbIEC4wl06 ql-ؚ86L Daʬ+@W0`cZNM41]씉X+&VTƊ]26RS-)666`+	؎h *`5ıbk A4=nD[4m͸`cX`cc6-`hhiJ66`+`bh" !0!D4&c'c%d-!ҽBASE      o  xA 0:;<0-M^qȝe\HJFCs(ELKQ9 $	,"*ʆV3U@QgN!@ mc	 U XNR b@m43u&@ 	[D,6L7Źd1Y6c[ɖ0-6d Lݶe jl36t%K h$RL`1ln*2scdTʰb$mf,Z\me$)JJ)RfB	2nd(S-*cAIfJT+1a@sr 5`	s56c3SmTh0ae%  @rS.m9 tmEuWvwns+uvwԻU]UyUm۶mHU*U-   ʡ uw5 *pTUŀ!BPOS      u  xq$E@q鮬3{-L'DKV_WkOwfEkMVNf2gFͤ]If4VɌFNI*N@IC餔HhQJ
"f6ABZ	(i "-i ECJTD!i J@DhnhhJ
!A) QiC	HJЦR)PmFJ)(Fj(EJf
jh6P64H5T
iڔHsZ(U-͙T"-fD9ڒRUwfJjgRՌvvFv>#'LX	ѵL&DvӴHv#Y3?tyy='qxzx+gNys^/f۝k=];ʽVzR;Yre6dg^YkV}G?>g_[OWWL<}x=$鐳=w|:{9'4mc}?qCCNF4        xQrDE+J%՞a zC<KW9_?q3i#mCud6V0ºod-/vjʀ|۩
+2g&'2}'6VCk6	<cJLX*,
dC'32O	̯@3`	PY<!0yF` G;dOdm;'a3d	=E`3P!eL>1OͿ)dQd<Q2P`oDaKVJmLo_mM-yޖ=v{z]y~&>aL>]2Z}{ܾ}w[<mK%>S5[\nmRui޸붦rK)0S\m|8Kogծ#a8Շ>P˞9TN1%uhj4
D-J#Т#*}dh)wgȨt,"r0vS(0v]<}FTu'3]3tuj-zwVS훂=`KMB-]зQ6t-ZLxxxx?ųTEXT         xn@)t2=FLl4D²95>GlUUoS0 %cyoBPzdyoBj^'WRJًz%Uhj,s8G?s߯'Mp{V{
!]`Ghxu<{V
GW7CLIP       	           T     SZTR

SMP4      Lg  xKˮizͳy7Z$'IݲӴԍj˲DI9'!x 2w6U}v:s'pRxjW_/}׿7wK,=wٟza} B̲Bgn[if\npu'-{롏zi$cP`{bKK
W̨ <U&C KR=M OV0DS]w /\CR[NZD%-Վ
b@w ogn8 8a98zY۹bGsR=:qoqӨoX /N11A<fs;gJP++RLq=_?oCҹ5u=>bێ!m}!\sXZyHݺZ=V?UOjv1zߎ|m/v:8Gu;a__׏ 9g_.uː?ns xkO~YrIk N._C| MK۷Wh[L<4l&!^tlSÖA*_	ӮtC,rAqz~~&_B,!)<׽=p2Lena׽dC6V]B_sH!_H;~֧!kc-cs#;^Ux%c=ևq]x9ۘ4D/Xx}{+a.'8\hՑo1Vrבx?};|}8$kϡznMG}fFr@o[v__ƾV<Ϸ?p]<K|7\ x~z?|;ڜ1a!kv1/VViYBb&M\2'ZQ;߆]!ho?媶ڦݬ0gq}yMQ1"OtDso|Ry>~m.Il92O|])1=OgetQil*Ni@=MRݜoL~9z*]ލڞ߯r
x|T|a|޷2O.N{V4[.^-rv_<!,3Dr8}Ƿ`_Q.xYCMsg\zK>xγB5[~j-67t˳b2Yc9jK}]?-Fێ6~5I4[ ;yR '˕ޟ$o	OG970",)zIK+i];1ԳՊ~o-ys[HUnso/nC]wGL\~գzs8MBo[txLDEY<Ƌ\~yr}ۏp@>Ð|?=q^3}L7xKKeBa'8K\^[hpqA<={9^wKm߶G
	C=ܮon/1<7brrvY![\!Uoin6\]羟v9{>8Vf]3ԩvD۵,͖_B~<]S_%osGSFIk]C)[u]s?_Rl"߷G<1tQ}G|м3cm@K2>[
l̰Z"殰7赬ѯ1ݟUK1˳cc*{Iz>BuOTjgr_nӻ}^q&]vr=x{)̡GtO	Xu>K4['8^ogcm=eF[Y<J}ߕޅvD\p,0K"{)^S7uZ7j~N
}zneKq'dbVrJt۱׋Gْ-,o4C^WaxgC}=v&C'~m~l@**6Sx.Ci&;/_QSW;{;k4{8ņ|?Qm۸7-䞖"zw~玁,p#_u-]cfP?!ߍ| ,OQg;Z~>u}=vF._Clo9!фVVX\bia%5=c]nZ~yNÇ/"xrBfrWm{~<S?}op0(RQr͆^䀖߃M2;ގO|MkP/4E<>}HC'o /P
t佟p;֎puCy 'lPR/¶oAӐc _Mx=_=80SjݶqlQ9)30}#|`CJqQ{Gmɾ>?uHiײq2kg-{4K-&Ӈ0Q_8zjxE4)4-v fa bX~Rj[J[;${RsF=g>cqgk1䎴?z?Bغ$.yxx=h!XXWH5NSu3CN4ZqbÐ>l
#OGS+z1Lk)5(Φ<Dİu-f>sZ2.#{;qX\,'[
C/ W?@|b,._AcP6@-hf˿Uk'\+0 P^u}uGZВꎊaҾ?R@GԞd1ѬPJpiPu$ 7!znCcџ9;V0,jM" Bo[?,E pIeg%\WU"Ȳ%C.惘4utu!QqȴV߫3#͸D^ֆl)$ySլI	qj{k=0Tl ```2pP[ꁈy[-=ŷ+8cdpnØrv:2%8{,`41lyɻ1GZv]pcogs{r%xBl}HvCt+}B	A/[s]1BNFssGDS߂n)V*|C0j)V7	 ɛkUc+ŀwH!$G-ahCŖɜ':0z)gJ\gSR+")q;@@CBy\(y=Kꭐh#{}t]!Zw`#"(h& .\~..MeNGR,4@n$ZcoƐm(8e ֎ȔqُZ;Yr.^z-j $D Su姐 kwyXs?.6]C !ǐE;bB݉=Di!k{R+Y4K=`hCeFu^]w:["aZg^JCst}MK7:ǁΩ>F jې GHJy=/5xe  "`BpN F@r8>6948R`]Zp^_f\XX٭J.#LtgcACceg;48%$GN"QD	@!A :( n -	tr@hDH9@8(J "ANHD
]H@SN Dt@I;%JtP @ A" B)tR 09)pvPKANH4AZ";$B" t@%C(.EiI .@A $PZ20%]l/"%A߇Nw}ɠ H$( &$% @$ @PtIFA(P7FH %P DA$ZF @\"(NsE	t@ !tp\/	7  % D0	DRhz(,%C !:L!:Nin U
U !h @ PN:蠖  J`*NKDtth(Z"J!%ANrI`$.#%B$$.Q 
% R : (Ptt0;K( qIAÖED#8{_"DD\В @!
\ D%@$pAP&vE	*dU(D
t. hg Bu J;!	 sA
倖
@HQZD@0 :耬
 ]tAK]_ -	 @\%]0@tk-Ub*QN  d D8!B	h9D@ D$n('$/@k	D:@NjA 0$@ h}Hr@}V>kku0޽*%p_UY
ӴQ+zm^j#&̝s5DkL!xZ^ 8O9r<%>[=O$*m'ayB=v'm]Ȟm3m{2iZz;quR/mw`3Ceq+ZlK܃T_W) -	K^c
-u:4تi~ZrG\^@y{̖o N?v8-J.?z=rzap-y:#|.SG"-7x{m>\fB+Qwb^Q>}=?ۜPML0kmhuqiuxƗV#R5w~yއ!:+.xLb&D»ڷ<ogݳr"-D0[7fچ%`{Tx5rTQ;ǟmn+^^%Ð*rTX>˗s8\ˤDsun3[_?`vD^ZQ~u4/^a=C៷G|'P;<_#nŸ!DS}[O*8:52j_?JaS5]oqnxDXFokr`~x7^:BLJ/{rmÀRc\"[Z˽pI`¶%rHiGJJ_wƗ>W5`WQxxbUҦO{\'m!8M2C`εp|a8xdrHoGoemû)CsyHaјXmoTXBaMh{4?jmLck@/"-_CdkO|yݢ_n\o9T׏i߇vVxOۧV|Mfl_?=8|Gqu/)a.I_,?c{;_nqf=upǺnw<Yof'MwǱ;2J1Yᚒ;u>vo/ݎr>*&Dz;\iDmrۺr(ٗAH3~m[CfYJ_/v>30]r;Wp7l8ǜiT#<MڨGl@dc1c?/[@)K߂Ya(sckmSy:Ǌn"gyK9N._Cv4u\@r=eHhۧJgȣ-W5H<LG-	ח|Oa@wӵĄi`GY=ėi>,-Sf7-@~q֐m#,$/7n\VeQISN U]y%/맂r}?}}=|<ugq[kBv"?1q51moM/~~v_ơc2zXnP;4YdɌ\3z-LhHb.lbtz)˷PC97oa.=h3GGoClJas)u[GS|o<lxOCї߅zhaC(M!jDNc1?nh{HJ\W܇`H<P-rI._Cvp|bTB\~
E5x}~|}]]~g-vr;joez~._?_ڏ3\f|aQ0gʄv>qöN_|x?~~|8KJ@.ކ-Ks1φ'*,=oOB^Ӈg>%\ǆr@^jxgӬԨ՘ǟ>ŀ&.BޞuQuyyӇqq>cBqٶɦ9Nї׭kx]xmű'[{trʺOqwC2">kcx=q3=ܑo [Q]pnڇrmM	>ױ㔺u)<aCn2'K&.
<}
"$K3tc;ΏKȡl9[nyTxew]o\ǭ"#Pb[x-0c4E0埠ײYBX-qhE[7l8na#|uݻiL1\yFjeo˿aj>!d#\}nc(q~
)11#-z(hr-%hm5MPNC1m}הK,8X z+[Tj/)0$B轟&dG=ϳR@2B~ ѮiP/^=_G^EZ#s巠v"y`|SqM<3P0f(9\l6Xy=sX^·i@Peov"_-cm Kk#bjr
яu
Ӻ噡:6$K-Z}%wvH)ൾm1DeK7@?н=j"R ,?.?BUڋzxD/gc;@ƈy-YH=cZB~ʐvIJK"̂S){i`po*`P̖pIj6&$a{P#ܑryNJ9RO<ÚesȫUr.њz+%3VG؜;H*SγD3I0 2贊qJ+9'j[:XT`kS3MN*`\3SB1YDuOƐvBcXw5^lQ9	w)rC mo@LYPa֝oBZi)8ck]A`):_Bח\{ۇ/G;i<3lٽ5NK,5"x:dG]GX;JĔ)R !P td}ǐrt^1BYXK`lG1y_AJ=8ųGLArHD{LsRqjJL5JmBF8<#ɬr>]ÜnG}S,!9C^ 3EoP:y"C۾nxIֶ,C>>!I18<-y>o{Ipjy=CA#N;KYSR}0_?FVUOko;zK5Y{4|	5ŘRL7Px}}EkympYCXҘ0+0@n {[b9VSdN=:̖A]ZiSa.19*ν7rӔb`^&J<Zݳ`1Skh]FދG70yss: .z-n6EOz<{};J pm`o#&MɯPfc6ǎ<2supB.ܞx-xՑV2ճ{>\9!zi]{A4 H\~Rw:z"yv$Îh17kBhÏ6ML2hbH:m-!ݭB覀؉>csX_K!1xy;<9v2b譝x͑0Վ`!tvIt&!tgr6fWI Cy9T9$ b:A.	 Q!tA&	*D$I'.E%-$j@EiI	%@NvI6A )0 ;$QD%JA@D(اgc%kDHDH  ]-"!8 E.@ӵ5wF\t-tD
 t);%@ @AA J"-$: @	t]"$np%(	(@ tBDjI.@ ( E			"$kAJ IA K@$$$wv+%_@d %P B/褜z9GgحCV@ttRED9!D_"tPDJ\"D3 R(8 (.%.-	tAwHws QZB] @ d]; I9̝
.[D.Q0- QK]	fY	rBtP @ B(dp@@(P \ 	g˭@p(
  : 
h%%vDB  BD	Ai@I em=~zc̹ZN"m!B8mā"!$.pR n *MHPJ	 E^k1zQ p:ArBt U2nDBK$d]&R t@( tѝ  0 w@r9H
t! 
.: zIJQ*	"`\D肇sv .{蠓N:)J2wg ]%rŐE . Bt(d* s<K J 瀕@ .$>dpI Ds&JH:Mr(TVYŰ
 袃^2D
!:@tȁ"(`2 epK DH; K@ A4	XDP@DW_ @] 6zɐH Q P;!RQN:(: J*A	t@ (H **@%A:7:M2ߟPkC 4Mal:djO;r$wF	{>G]ۨD 	.S7lɎWs5z.|gu˨gm2LϚeh$s^1ԃ!GGҏ1}\ju1"1IebS/<gu"Y%V-欭ļ\;rNrz;:2n,WwcZMv2,k6`rQ~}ɗנ>G)i	pǾ$.25QϷe̞H˧K~a<{S B{Ш,];k}#S0q:>0noGQ>e	F+7잯/Ѷcw^eІM/[1n|YCqI5U.8c^x۪Ҫ<e7s?φbWygtR65{=4{b97׭[~SSvxk
i{OgO>__87nGm:XBV7~rc{ӯ,WGϟV ȐB|D2B'U~-ŬqQ,~yTox<)]sy#x1ʬhy~^2a8[,B{8 oK\>|zU
ucK|8F;+Ř[}x޲>?=^^/i:r|}Ikk
ͬjmW|~}yY?~?/`h㌸ȭ>EOrƁ'4e,ofm/W;NPx>[<~?ٖZk~~pGT oOs
ǿ8z!T	]vo~ח%nc S:|l ~#ku]+*?~ןo}==1,¨? 	pٙQ;|x5]z?,/~MK<,7hq48zK7}k:z0OqC\nǨ9\&G4fgA<oy#LSv @>Қ1¼L#BA_Ǵtʟ9_zx8NT^ T@m?́ {mvoܒ"߂Zn6|~z|7:F+?J,Ў0}2[}|y6͹;ȫ-)Qq|fFr|ُR
=;W}gP^~B9<;4 l_ql$f,C}˧5x{[V~tIF`IBpˆ{}{9j@(?h|~YSڟ_Rr=|bHg ZB~JlrIx^{Rw.yF}Ccp`Y<br^aeehkol#/kcg[8}~켿)9	AޏPCN&hn%x[ԲclӼ̱ˮ)eT1λc]?E>_ksOv(umǗx\cbv|ɉطyJ[ݘ%KW{(xmY4+N|1CT@J[^xfL!x[~ZsC9OnckǶ=u	Ѧ(?1-gx\۲4ng+sR`C6-W܏ iטm] yf4CN9)w!dO9{D3xgq`LVczx?w9O#z("Q+[tP~8;?|Ǯ'8O_3Lz_|u=qKShG^/~VUjσ˧+l_uxq,?-]?]Bv֗˷ԟϷbSC(?Gp}S<tҼ||{gm]0b훯:ۗ#}}xL!xrtxy)V:OGYsܾzoxxM.g9S){;Ǿ຦p}?rܠqhu~?j5rZ}Z+=v$bk>" .)Qvp]cH1w5MM}~uO/<~L
2+789/Y^[10c ~{^kr~7P8uzSڷ6]Fآ?na=͘ܠ^uԞ/0e6ƹƾ羙Ob@R{t+_<-DM叡V7p[~|9pU
Ijݿ<t1oB>88E::2?{GJFvNK
=ϦP~F͑2_<x x]־?:y"5~>z,=v1B;Ͼ1F0{q5606Ml=ZX[>tʉ2	eYN۶f߆4fi.:-1B>Nv͗%~t13F`æH]-غb1`F|H)	y#y<MO~}i/e+k
αf,-\# o5iE+jv4Ok1Lfe1N䄶y`VfuZ	3+޺/ȴ^Cl"߁q$T	D%B.ϙE̶,+$hm O>h֧l5ܽ&[2)*}q֎玤'sz5G;i*i' ߄׆إ1X@kaF,|@7rzI,@7V_T}lԂ[(}x{7ii~ޟcxv A;U|ضdr6<_}۶y.G;Gph,B1D@;{LY	t!z':x?0ϹV3ࣱ)-̃g?Xזܬ:=Ic;ۘb8۹ơ4l6uY"Fh~r9Sޔ(hIqዂal[5Yhúd{1YLQ%֪B0}[lIgCPHn t[584u]c;ɒIM ƶOq4Fߓ8eC -߁%mpTS`m֧LJTT(B!5BШbg)h#kXӤ~0`o@d	\CN=q:Ǳ̙` ħk|ǲ|{GfqPJ9)-:|rE7bXy>ίXvlRZAx{aJjkM4`O6&V<'ݟWL]Bw6	6ԬYєmqȚ#'wSBF$ʯBiXfk%#lm0F~%qsis͡u<@%s=}Lg9κ`  ,k~{@ZM1̱dt=	ioGlNɽshKL'M	D9Z%[ËMUg?֯1Ń]6G	GnƘ耥Q7f"A=@BRIц	, @B]Ms wd{8;kr7G%mRJ~fgP?:}iLnB0=,`Na21(w9 Dp#Tjt7p.p~a{ږvgmGPmh.7HƨU A	p "r3rhxxoow[B>> .ZG`B+>| A;9<Rp )Rއ#Byҗ׮eN{a݌mDv9觙8Lpu]9u% ,IN,h4ud0zik6'܇@,Y.6w;#8;̈>d!4F.\eOKS  AƠ@,rHC*V^ 86 r8|!%ʇVG=" !ҀAW Ha!PBu$TI dr w!@2J r@6ED$U28$:D"$NJ *3D!J`b DW! @  bX % PH8  BT%BAHtgK!t0$
 
: KD$BN$
X"I JKlVp\ϥkXpP"! 
A A	).A'$P%B@/*	"T{" p :DN"@8(@4g)@gg`2\ (pV8(`.Q0J%fs@ 08(pY*T"DH%sA BNt7P&A0Dt$
&  @ A]	rB X@J$ : :A	K@@w Bt tJ;(Dt " .A/BPP R! $A(Fp pQ	7qpNz(AD
Nw?@ nA	DtB%aT	)@%B%H	p'a: Rr92. w)C"DR!:"HwNN:6@(QP $ "
.@2%
0 9 
J@IDID"EIN
tJ P \H (Jt@@ĀqX+T28(	9(%**t@7:@ zD	tp	 D8D  $~Rg),"kgHl4IlT<qj_&Ta<cBl5ɃAD}.;9h@-bQqɳ򻐏l\Ǹw|Fp"pNyCj2+B/0.Sd?cjk! nk8R^~Re]2G!BCCZN[SY-8</Yϱo<A6BzxUĴL-CF}lcϷm{T||^?m1<hV!xwK<xyS,'WL[(?Ԛ3W8_c/0 ߆F58<8r׭kޒ}}NqD
>ڃX^47ߎfi,֯0/oٷKr"ǉmm1͹ n~I8R"B"2nk*"xzn`CcL9X>v4_y=y^#05='D'߃HofX<zgviY >uhǗ6M׈oB>ڴdk6_z:_v%A
yKñL+
f'咦TKB=>ܢCL0/Bj#~t?Ƣp{xݻO؞?oPGo[[xlG`0_}1=|>R^z<c._רx 4kADe/],Fq?m.aq}??囕lN/L0ޱ_q_>0!{C<eR=v)fV41,ˤsؗ3Z(:O~,<#x傹o_.kd9xر,B{^};X sOOi	GT/oh*A^ݍp?ʎX~uev-R}[#s!)Y7h;xzxomD#:˟@^#^S֞f<Z`i~@9{;ϳ+yn_v|clc%a +jOcb~}4Vwts=ڣFL)w#0 ?sa[J)̃퀅)1~}Tj;6KKɌG_zVhiQ0vztm<ƽGSZɭm1Dԣ
`uڶm:)3~B1._^W|ly!a-yGcz]bҿ|%0Y@(a쟾z[Y	uYYwLj&?׭r[Wk
ͬ6|mQ<R5+/lӧ-!«9͓sߛ}un||].Cgc=_rf/H9T%\kǾo!/`?xs>
qP!ϫP?zI?3伀d0ݛc|	Ǫ%5]<]m㞮!|+'G˧bU@L-BZ?v!\evl/p<1gk܏]2B)ب5{ܯ;Y'x=Fs;wnYV~vr1|/mD- ouL^?FiYm{4Ҭώ<}xX%POyޞQ,O9%g՗zYF?>uV~~6v>'5ZS)|a<Ud;$ft}#LPo0,o`\4)%Jҧu]ԏ<2Eh]5xK̬};Ϛe1oḾ4+BR;<yy&aV~y;wc1G|woJYf9zoGD^k=bZS8O
yo[R^̉Ztt	uL1Փy<O1F!x.Swn`(ћ)D<RmۨM=?bG?XCN!~<l!w<֐%Oՙm

{臝Z38sDM	oiy|	[0+W ҕ|hS˰1N_)5O9_F;`ZsHx}:d1ɖ	<{ɬS%:,ipLP
$^:MQzC
I׳銹sdP rHc4aeIG1j4z{03Gk\qt*GY42Cۉ.};ρ)2
%ZIӅֺM)(,.ZhhHLSpI{i`^0O&Qꭹ-QNY{V~:_0&"C99j=9P9maV
\rqXpð-9C7cLou@(W 䭶&cîNɖ1fwgd?:pXd!pxݦ{$XAq"Sɘ[*
|$bΤ0*'|8a)K]
A֐zp?S`(%DπQ4ǨӘe,߭i`T?ns"<Fih%琼f!f3֭>yLjqA'j]6ڨOxj_n5$ƥў0(@.9Ccό)\C	Sm=X 6o٬9& +#%iPM'Rlj3X
	%c<j=f!1XfpԽ)'Dc? iH)4{}!QpG#LxLd YYFJsYk_LM UrR1bs[~\ޗ[)wgpX#6ե-lݭ	%u%c^<°8t}m3kEF  	,A H !x3x,P_~=f	AD !ΙQ(r|_~u!H, D`J$6aUİ
DV]H J@@ @0"1BRI  "P!D*	"@4 E	t:A9!: %@4:QK,  
 (t@ ɠ@DtؠH8!*KC%Q!H:A$ld($B,]"@'N
$pJ@HATD:A(İ
 @Qt7 %DD@@QD
 : :! : 
"`Rɠ*0	CC!Rp&Dq%B  :,Pv\dDH,O tDP 88H U=f\V4HQRW/p/s¦aqx`se*tdOb
,+etHv, \.2dYMõk_T\iI,"pX8Ýͺ,	uߤap$ y?t?:w	N`qBc~6-q 龱73~vxtNY$>>@0<AOa4l~uo /dݟ$ݿIE'9``~q~p)J`7I2.t7ÒpY&^1pJci@:o܎e!M'8$Hv?HHA0MAY|(BASE        xA 0:-MަncPHT
J*AbJp%Ҍr1j`pl0W"j9)6WHr)DjH")HX*Kd)k)PB)KRH$̹a\M([
8	%)u!*NKT-ۖ4*J0mX%1(Bڐ*mUdsj&[ȶprdtSlEVΒZLF8״rA`TժT)A,W,YV*dmSiZ-NJ%UV8 mKS3m
UN H
07e[izYY g UKTj۶mwpU)MUvqw۶MjS
 @* m[T]Um۶e"BPOS        xqV@";=>>>V9ɉMJsgfҶUd2I&'f%k*I92mf6dDTBtgfjAW)"(цфTD6TE[B¢ڨ
 Q(AiRBCJ#RRh@%ADADTR	! 4iLi
 )
(Hi4YBiдMjhAj6fu*fQl6*V;tZIb^sV{NfCVRғ>ҬLuder]NB?l4^)%:gj5r63ݽ\_&Z{e<'=yLzI|Wnb}wy猟果s=_y<Ͻ{Ϲ~߯f޾{3?l,?CNF4        x]r6яl?"EdWRJ^ʖ4cAsOlG-z8?\|LUJ~xV		S܆?MN	T(ݩr	P0BZ<S)3R<c2y@`z<a^)03C1
0&yF CyA 0/&<cC!	a2/		yyF0!¼ ̏<#0yByF<c>!0G0?"&#|B@Od`)>a>1C1D-17N3PuΜ<Q@m롽0x A 3'Pa=l']|z>FPv_<]-j\o_ٶ9bݱ|?y9Z朳xZtXK+y.=\Zhoo}[_f]?Ǜem<֕).y~ϭc[y>-[fq6Q]S[8U6EMˮ4F".Ւ7z.u*_Nc/z2{l}B,L+hhK[>!"Vbʴ9щ40]	Cl001/pB:l`}5ʇxxxxgTEXT         xAn09 8$[iEH"%bY{%$q(ӈ2.V*N[[K_X؃GA[E)i
٨o|J}E)i
]aJ,1A4z jTSǀgUi]~=p~S>г>XָLW9gy<pqˋb脦447CLIP       	           <AlignableSequences trimStringency="Medium"><Sequence name="20_12.25-NW1540-211221-02-40" ID="0" isTrace="1" sortOrder="0" trimmedRange="18..1072"/><Sequence name="20_12.25-pcDNA5 Rev-211221-02-41" ID="1" isTrace="1" sortOrder="1" trimmedRange="255..1291"/></AlignableSequences>  O      BC N sre```pp23*+/*IMbqqQjZjQj^r*) 
d6         BC 1d5B -K8A.9lR&8 BĈ#`6 H\p=꠳72 *jooGl&~?~^nW_=߶~_׫mzsURMʝ|Va}SR|͔qYSN$&kTQGW*YTEY:jCB(IFꓚjE9ԨB<@Lar!YJf.3TkIZ2SK05X3,8>iaW=ud1V
l"p.jii!^i֊b;wF$v\XRU0H\gcw-p{
TTi2`**q71LbUfφ:Eե3YRyP5w)ͣp%(C5F2;(&7▔tL[&DB3S߳p_xu0='O{#!j^\OMlQ|tenٓh.vLlL|XX7\~ώ/=ͷ+]A:HA+ !ߞ=]%QLFT~6Sv9!EF=C DTOb76ybڡ"bkH`DW]A	@Zc"}d
Gݩ2DCz@N<pqR4ΜĮAsf]mZm1B%9 6@z+\TVeh5`H: "fR8(`gL5;MRP>QH)wИ)/JфPe&j PA$L8*!ֳL_ȫKݚ(	@"f<*4	S}՞"zlMbBwڮ.vo/@o/        BC             !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ,<?xml version="1.0"?><Features nextValidID="20"><Feature recentID="0" name="TMEM55B NM_001100814.3" directionality="1" translationMW="30186.48" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="1929-2783" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MAADGERSPLLSEPIDGGAGGNGLVGPGGSGAGPGGGLTPSAPPYGAGKHAPPQAFPPFPEGHPAVLPGEDPPPYSPLTSPDSGSAPMITCRVCQSLINVEGEMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGPVHPGPLSPEPQPMGVRVICGHCKNTFLWTEFTDRTLARCPHCRKVSSIGRRYPRKRCICCFLLGLLLAVTATGLAFGTWKHARRYGGIYAAWAFVILLAVLCLGRALYWACMKVSHPVQNFS*"/></Q></Feature><Feature recentID="1" name="HygR" directionality="1" translationMW="37901.58" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" hitsStopCodon="1"><Segment range="3429-4451" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to hygromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;hygromycin B phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="KKPELTATSVEKFLIEKFDSVSDLMQLSEGEESRAFSFDVGGRGYVLRVNSCADGFYKDRYVYRHFASAALPIPEVLDIGEFSESLTYCISRRAQGVTLQDLPETELPAVLQPVAEAMDAIAAADLSQTSGFGPFGPQGIGQYTTWRDFICAIADPHVYHWQTVMDDTVSASVAQALDELMLWAEDCPEVRHLVHADFGSNNVLTDNGRITAVIDWSEAMFGDSQYEVANIFFWRPWLACMEQQTRYFERRHPELAGSPRLRAYMLRIGLDQLYQSLVDGNFDDAAWAQGRCDAIVRSGAGTVGRTQIARRSAAVWTDGCVEVLADSGNRRPSTRPRAKE*"/></Q></Feature><Feature recentID="2" name="HaloTag®" directionality="1" translationMW="33609.62" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2783" maxFusedRunOn="2783"><Segment range="1008-1898" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;modified&amp;nbsp;bacterial dehalogenase that forms covalent bonds with&amp;nbsp;chloroalkane derivatives&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MAEIGTGFPFDPHYVEVLGERMHYVDVGPRDGTPVLFLHGNPTSSYVWRNIIPHVAPTHRCIAPDLIGMGKSDKPDLGYFFDDHVRFMDAFIEALGLEEVVLVIHDWGSALGFHWAKRNPERVKGIAFMEFIRPIPTWDEWPEFARETFQAFRTTDVGRKLIIDQNVFIEGTLPMGVVRPLTEVEMDHYREPFLNPVDREPLWRFPNELPIAGEPANIVALVEEYMDWLHQSPVPKLLFWGTPGVLIPPAEAARLAKSLPNCKAVDIGPGLNLLQEDNPDLIGSEIARWLSTLEISG"/></Q></Feature><Feature recentID="3" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6703" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5912-6703" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6704-6772" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;β-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="4" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="5153-5741" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2866-3090" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4581-4702" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="6773-6877" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="FRT" directionality="1" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3374-3421" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;FLP recombinase from the &lt;i&gt;Saccharomyces cerevisiae&lt;/i&gt; 2μ plasmid&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;FLP-mediated recombination occurs in the 8-bp core sequence TCTAGAAA (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/21891781&quot;&gt;Turan and Bode, 2011&lt;/a&gt;).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment name="-10" range="4799-4805" color="#ffffff" type="standard"/><Segment range="4806-4823" color="#ffffff" type="standard"/><Segment name="-35" range="4824-4829" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="HA" directionality="1" translationMW="1102.17" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2822" maxFusedRunOn="2822" detectionMode="exactProteinMatch"><Segment range="2793-2819" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="YPYDVPDYA"/></Q></Feature><Feature recentID="13" name="HRV 3C site" directionality="1" translationMW="902.06" type="CDS" allowSegmentOverlaps="0" cleavageArrows="1916" consecutiveTranslationNumbering="1" maxRunOn="2783" maxFusedRunOn="2783" detectionMode="exactProteinMatch"><Segment range="1899-1922" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;recognition and cleavage site for human rhinovirus 3C and PreScission proteases&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="LEVLFQGP"/></Q></Feature><Feature recentID="14" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4844-4865" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="820-838" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="tet operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="841-859" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;tetracycline repressor TetR&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;tetO&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bacterial operator O&lt;sub&gt;2&lt;/sub&gt; for the &lt;i&gt;tetR&lt;/i&gt; and &lt;i&gt;tetA&lt;/i&gt; genes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4751-4767" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4775-4791" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-β-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="K103E" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2235-2237" color="#a6acb3" type="standard"/></Feature></Features>
  <?xml version="1.0"?><Primers nextValidID="5"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40" showAdditionalFivePrimeMatches="1" minimumFivePrimeAnnealing="15"/><Primer recentID="0" name="Primer 1" sequence="ctgaccttcatacaggcccaataaagggatccaggcccctggaacagaac" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2021-01-21T09:37:12Z"><BindingSite location="1904-1927" boundStrand="1" annealedBases="ggatccaggcccctggaacagaac" meltingTemperature="66"><Component bases="ctgaccttcatacaggcccaataaag"/><Component hybridizedRange="1904-1927" bases="ggatccaggcccctggaacagaac"/></BindingSite><BindingSite location="2732-2757" boundStrand="1" annealedBases="ctgaccttcatacaggcccaataaag" meltingTemperature="59"><Component hybridizedRange="2732-2757" bases="ctgaccttcatacaggcccaataaag"/><Component bases="ggatccaggcccctggaacagaac"/></BindingSite><BindingSite simplified="1" location="1904-1927" boundStrand="1" annealedBases="ggatccaggcccctggaacagaac" meltingTemperature="66"><Component bases="ctgaccttcatacaggcccaataaag"/><Component hybridizedRange="1904-1927" bases="ggatccaggcccctggaacagaac"/></BindingSite><BindingSite simplified="1" location="2732-2757" boundStrand="1" annealedBases="ctgaccttcatacaggcccaataaag" meltingTemperature="59"><Component hybridizedRange="2732-2757" bases="ctgaccttcatacaggcccaataaag"/><Component bases="ggatccaggcccctggaacagaac"/></BindingSite></Primer><Primer recentID="1" name="Primer 1a" sequence="gaggatccatggcggcagatggagagc" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2021-01-11T10:42:22Z"><BindingSite location="1922-1946" boundStrand="0" annealedBases="ggatccatggcggcagatggagagc" meltingTemperature="67"><Component bases="ga"/><Component hybridizedRange="1922-1946" bases="ggatccatggcggcagatggagagc"/></BindingSite><BindingSite simplified="1" location="1922-1946" boundStrand="0" annealedBases="ggatccatggcggcagatggagagc" meltingTemperature="67"><Component bases="ga"/><Component hybridizedRange="1922-1946" bases="ggatccatggcggcagatggagagc"/></BindingSite></Primer><Primer recentID="2" name="Primer 2a" sequence="gaggatccgccaccatggcggcagatggagagc" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2021-01-11T10:42:38Z"><BindingSite location="1926-1946" boundStrand="0" annealedBases="ccatggcggcagatggagagc" meltingTemperature="65"><Component bases="gaggatccgcca"/><Component hybridizedRange="1926-1946" bases="ccatggcggcagatggagagc"/></BindingSite><BindingSite simplified="1" location="1926-1946" boundStrand="0" annealedBases="ccatggcggcagatggagagc" meltingTemperature="65"><Component bases="gaggatccgcca"/><Component hybridizedRange="1926-1946" bases="ccatggcggcagatggagagc"/></BindingSite></Primer><Primer recentID="3" name="Primer 3a" sequence="gtgcggccgctcaggagaagttctggacagggtg" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2021-01-11T10:43:05Z"><BindingSite location="2759-2790" boundStrand="1" annealedBases="gcggccgctcaggagaagttctggacagggtg" meltingTemperature="71"><Component bases="gt"/><Component hybridizedRange="2759-2790" bases="gcggccgctcaggagaagttctggacagggtg"/></BindingSite><BindingSite simplified="1" location="2759-2790" boundStrand="1" annealedBases="gcggccgctcaggagaagttctggacagggtg" meltingTemperature="71"><Component bases="gt"/><Component hybridizedRange="2759-2790" bases="gcggccgctcaggagaagttctggacagggtg"/></BindingSite></Primer><Primer recentID="4" name="Primer 4a" sequence="gtgcggccgctcaGGCGTAATCTGGCACATCGTATGGGTAggagaagttctggacagggtgg" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;" dateAdded="2021-01-11T10:43:50Z"><BindingSite location="2758-2819" boundStrand="1" annealedBases="aGGCGTAATCTGGCACATCGTATGGGTAggagaagttctggacagggtgg" meltingTemperature="70"><Component bases="gtgcggccgctc"/><Component hybridizedRange="2793-2819" bases="aGGCGTAATCTGGCACATCGTATGGGT"/><Component hybridizedRange="2758-2780" bases="Aggagaagttctggacagggtgg"/></BindingSite><BindingSite simplified="1" location="2758-2819" boundStrand="1" annealedBases="aGGCGTAATCTGGCACATCGTATGGGTAggagaagttctggacagggtgg" meltingTemperature="70"><Component bases="gtgcggccgctc"/><Component hybridizedRange="2793-2819" bases="aGGCGTAATCTGGCACATCGTATGGGT"/><Component hybridizedRange="2758-2780" bases="Aggagaagttctggacagggtgg"/></BindingSite></Primer></Primers>
  _<Notes>
<UUID>1a2e883e-d39a-4e4d-84e0-f0ec963f88f8</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="23:0:0">2015.8.31</Created>
<LastModified UTC="11:31:33">2022.1.6</LastModified>
<CreatedBy>MRC PPU</CreatedBy>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         Unique 6+ Cutters                                                                                            d     CHO  d             E             Y? P                                                                                                                                                              3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
