cDNA Clone Fbxo7

• Plasmid: pFBDM-DAC_TEV-Fbx07 R498x, Skp1 (TV1 Human)
• Parent Plasmid: pFBDM DAC
• Expressed: DAC-Fbx07 R498x
• Genbank: NM_012179.3
• Tag: DAC
• Species: Human

Sequence of Insert

GAATTCAAGAAAACCTGTATTTTCAGGGCATGAGGCTGCGGGTGCGGCTT
CTGAAGCGGACCTGGCCGCTGGAGGTGCCCGAGACGGAGCCGACGCTGGG
GCATTTGCGCTCGCACCTGAGGCAGTCCCTGCTGTGCACCTGGGGGTACA
GTTCTAATACCCGATTTACAATTACATTGAACTACAAGGATCCCCTCACT
GGAGATGAAGAGACCTTGGCTTCATATGGGATTGTTTCTGGGGACTTGAT
ATGTTTGATTCTTCAAGATGACATTCCAGCGCCTAATATACCTTCATCCA
CAGATTCAGAGCATTCTTCACTCCAGAATAATGAGCAACCCTCTTTGGCC
ACCAGCTCCAATCAGACTAGCATGCAGGATGAACAACCAAGTGATTCATT
CCAAGGACAGGCAGCCCAGTCTGGTGTTTGGAATGACGACAGTATGTTAG
GGCCTAGTCAAAATTTTGAAGCTGAGTCAATTCAAGATAATGCGCATATG
GCAGAGGGCACAGGTTTCTATCCCTCAGAACCCATGCTCTGTAGTGAATC
GGTGGAAGGGCAAGTGCCACATTCATTAGAGACCTTGTATCAATCAGCTG
ACTGTTCTGATGCCAATGATGCCTTGATAGTGTTGATACATCTTCTCATG
TTGGAGTCAGGTTACATACCTCAGGGCACCGAAGCCAAAGCACTGTCCAT
GCCGGAGAAGTGGAAGTTGAGCGGGGTGTATAAGCTGCAGTACATGCATC
CTCTCTGCGAGGGCAGCTCCGCTACTCTCACCTGTGTGCCTTTGGGAAAC
CTGATTGTTGTAAATGCTACACTAAAAATCAACAATGAGATTAGAAGTGT
GAAAAGATTGCAGCTGCTACCAGAATCTTTTATTTGCAAAGAGAAACTAG
GGGAAAATGTAGCCAACATATACAAAGATCTTCAGAAACTCTCTCGCCTC
TTTAAAGACCAGCTGGTGTATCCTCTTCTGGCTTTTACCCGACAAGCACT
GAACCTACCAGATGTATTTGGGTTGGTCGTCCTCCCATTGGAACTGAAAC
TACGGATCTTCCGACTTCTGGATGTTCGTTCCGTCTTGTCTTTGTCTGCG
GTTTGTCGTGACCTCTTTACTGCTTCAAATGACCCACTCCTGTGGAGGTT
TTTATATCTGCGTGATTTTCGAGACAATACTGTCAGAGTTCAAGACACAG
ATTGGAAAGAACTGTACAGGAAGAGGCACATACAAAGAAAAGAATCCCCG
AAAGGGCGGTTTGTGATGCTCCTGCCATCGTCAACTCACACCATTCCATT
CTATCCCAACCCCTTGCACCCTAGGCCATTTCCTAGCTCCCGCCTTCCTC
CAGGAATTATCGGGGGTGAATATGACCAAAGACCAACACTTCCCTATGTT
GGAGACCCAATCAGTTCACTCATTCCTGGTCCTGGGGAGACGCCCAGCCA
GTTTCCTCCACTGAGACCACGCTTTGATCCAGTTGGCCCACTTCCAGGAC
CTAACCCCATCTTGCCAGGGtGAGGCGGCCCCAATGACAGATTTCCCTTT
AGACCCAGCAGGGGTCGGCCAACTGATGGCCGGCTGTCATTCATGTGATT
GAGCGGCCGC

Amino Acid Sequence

MSAIPGVPQIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMTSYVIG
QAMKAGKFKETDLVTIGNDAWATGNPVFKGSSLMFLKPGMQVPVSQLIRG
INLQSGNDACVAMADFAAGSQDAFVGLMNSYVNALGLKNTHFQTVHGLDA
DGQYSSARDMALIGQALIRDVPNEYSIYKEKEFTFNGIRQLNRNGLLWDN
SLNVDGIKTGHTDKAGYNLVASATEGQMRLISAVMGGRTFKGREAESKKL
LTWGFRFFETVNPGSRSEARGIQENLYFQGMRLRVRLLKRTWPLEVPETE
PTLGHLRSHLRQSLLCTWGYSSNTRFTITLNYKDPLTGDEETLASYGIVS
GDLICLILQDDIPAPNIPSSTDSEHSSLQNNEQPSLATSSNQTSMQDEQP
SDSFQGQAAQSGVWNDDSMLGPSQNFEAESIQDNAHMAEGTGFYPSEPML
CSESVEGQVPHSLETLYQSADCSDANDALIVLIHLLMLESGYIPQGTEAK
ALSMPEKWKLSGVYKLQYMHPLCEGSSATLTCVPLGNLIVVNATLKINNE
IRSVKRLQLLPESFICKEKLGENVANIYKDLQKLSRLFKDQLVYPLLAFT
RQALNLPDVFGLVVLPLELKLRIFRLLDVRSVLSLSAVCRDLFTASNDPL
LWRFLYLRDFRDNTVRVQDTDWKELYRKRHIQRKESPKGRFVMLLPSSTH
TIPFYPNPLHPRPFPSSRLPPGIIGGEYDQRPTLPYVGDPISSLIPGPGE
TPSQFPPLRPRFDPVGPLPGPNPILPG*GGPNDRFPFRPSRGRPTDGRLS
FM*

• Vector Type: Baculovirus
• Antibiotic: Amp
• DU Number: DU24109
• Unit Source: Protein Phosphorylation and Ubiquitylation Unit
• Location: PPU
• MTA: Dundee
• Notes: TEV not blunt. ; Loss of nuclear activity of the FBXO7 protein in patients with parkinsonian-pyramidal syndrome (PARK15).; Zhao T, De Graaff E, Breedveld GJ, Loda A, Severijnen LA, Wouters CH, Verheijen FW, Dekker MC, Montagna P, Willemsen R, Oostra BA, Bonifati V.